The newly identified MEK1 tyrosine phosphorylation target MACC1 is druggable by approved MEK1 inhibitors to restrict colorectal cancer metastasis

Cancer metastasis causes >90% of cancer deaths and remains a major treatment challenge. Here we deciphered the impact of tyrosine phosphorylation of MACC1, a causative driver for cancer metastasis, for cancer cell signaling and novel interventions to restrict cancer metastasis. We identified MACC...

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Detalles Bibliográficos
Autores principales: Kobelt, Dennis, Perez-Hernandez, Daniel, Fleuter, Claudia, Dahlmann, Mathias, Zincke, Fabian, Smith, Janice, Migotti, Rebekka, Popp, Oliver, Burock, Susen, Walther, Wolfgang, Dittmar, Gunnar, Mertins, Philipp, Stein, Ulrike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390371/
https://www.ncbi.nlm.nih.gov/pubmed/34247190
http://dx.doi.org/10.1038/s41388-021-01917-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390371/
https://www.ncbi.nlm.nih.gov/pubmed/34247190
http://dx.doi.org/10.1038/s41388-021-01917-z

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