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Can NLRP3 inhibitors improve on dexamethasone for the treatment of COVID-19?

Dexamethasone, a corticosteroid, has been approved for use in the treatment of severe COVID-19, which is characterised by hyperinflammation and associated lung damage. However, dexamethasone shows no clinical benefit in the treatment of less severe disease, and prolonged treatment may lead to immuno...

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Detalles Bibliográficos
Autores principales: Hooftman, Alexander, O'Neill, Luke A.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390447/
https://www.ncbi.nlm.nih.gov/pubmed/34870152
http://dx.doi.org/10.1016/j.crphar.2021.100048