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Pre-retinal delivery of recombinant adeno-associated virus vector significantly improves retinal transduction efficiency

Intravitreal injection is the most widely used injection technique for ocular gene delivery. However, vector diffusion is attenuated by physical barriers and neutralizing antibodies in the vitreous. The 13-lined ground squirrel (13-LGS), as in humans, has a larger relative vitreous body volume than...

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Detalles Bibliográficos
Autores principales:	Zhang, Hanmeng, Sajdak, Benjamin S., Merriman, Dana K., Carroll, Joseph, Lipinski, Daniel M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390453/ https://www.ncbi.nlm.nih.gov/pubmed/34485598 http://dx.doi.org/10.1016/j.omtm.2021.06.005

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