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Use of Thiols in the Treatment of COVID-19: Current Evidence
There is a possible role for oxidative stress, a state characterized by an altered balance between the production of free radicals or reactive oxygen species (ROS) and antioxidant defences, in coronavirus disease 2019 (COVID-19), the genesis of which is quite complex. Excessive oxidative stress coul...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390541/ https://www.ncbi.nlm.nih.gov/pubmed/34448938 http://dx.doi.org/10.1007/s00408-021-00465-3 |
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author | Cazzola, Mario Rogliani, Paola Salvi, Sundeep Santosh Ora, Josuel Matera, Maria Gabriella |
author_facet | Cazzola, Mario Rogliani, Paola Salvi, Sundeep Santosh Ora, Josuel Matera, Maria Gabriella |
author_sort | Cazzola, Mario |
collection | PubMed |
description | There is a possible role for oxidative stress, a state characterized by an altered balance between the production of free radicals or reactive oxygen species (ROS) and antioxidant defences, in coronavirus disease 2019 (COVID-19), the genesis of which is quite complex. Excessive oxidative stress could be responsible for the alveolar damage, thrombosis, and red blood cell dysregulation observed in COVID-19. Apparently, deficiency of glutathione (GSH), a low-molecular-weight thiol that is the most important non-enzymatic antioxidant molecule and has the potential to keep the cytokine storm in check, is a plausible explanation for the severe manifestations and death in COVID-19 patients. Thiol drugs, which are considered mucolytic, also possess potent antioxidant and anti-inflammatory properties. They exhibit antibacterial activity against a variety of medically important bacteria and may be an effective strategy against influenza virus infection. The importance of oxidative stress during COVID-19 and the various pharmacological characteristics of thiol-based drugs suggest a possible role of thiols in the treatment of COVID-19. Oral and intravenous GSH, as well as GSH precursors such as N-acetylcysteine (NAC), or drugs containing the thiol moiety (erdosteine) may represent a novel therapeutic approach to block NF-kB and address the cytokine storm syndrome and respiratory distress observed in COVID-19 pneumonia patients |
format | Online Article Text |
id | pubmed-8390541 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-83905412021-08-27 Use of Thiols in the Treatment of COVID-19: Current Evidence Cazzola, Mario Rogliani, Paola Salvi, Sundeep Santosh Ora, Josuel Matera, Maria Gabriella Lung Review: Use of Thiols in Treatment of Covid-19 There is a possible role for oxidative stress, a state characterized by an altered balance between the production of free radicals or reactive oxygen species (ROS) and antioxidant defences, in coronavirus disease 2019 (COVID-19), the genesis of which is quite complex. Excessive oxidative stress could be responsible for the alveolar damage, thrombosis, and red blood cell dysregulation observed in COVID-19. Apparently, deficiency of glutathione (GSH), a low-molecular-weight thiol that is the most important non-enzymatic antioxidant molecule and has the potential to keep the cytokine storm in check, is a plausible explanation for the severe manifestations and death in COVID-19 patients. Thiol drugs, which are considered mucolytic, also possess potent antioxidant and anti-inflammatory properties. They exhibit antibacterial activity against a variety of medically important bacteria and may be an effective strategy against influenza virus infection. The importance of oxidative stress during COVID-19 and the various pharmacological characteristics of thiol-based drugs suggest a possible role of thiols in the treatment of COVID-19. Oral and intravenous GSH, as well as GSH precursors such as N-acetylcysteine (NAC), or drugs containing the thiol moiety (erdosteine) may represent a novel therapeutic approach to block NF-kB and address the cytokine storm syndrome and respiratory distress observed in COVID-19 pneumonia patients Springer US 2021-08-27 2021 /pmc/articles/PMC8390541/ /pubmed/34448938 http://dx.doi.org/10.1007/s00408-021-00465-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review: Use of Thiols in Treatment of Covid-19 Cazzola, Mario Rogliani, Paola Salvi, Sundeep Santosh Ora, Josuel Matera, Maria Gabriella Use of Thiols in the Treatment of COVID-19: Current Evidence |
title | Use of Thiols in the Treatment of COVID-19: Current Evidence |
title_full | Use of Thiols in the Treatment of COVID-19: Current Evidence |
title_fullStr | Use of Thiols in the Treatment of COVID-19: Current Evidence |
title_full_unstemmed | Use of Thiols in the Treatment of COVID-19: Current Evidence |
title_short | Use of Thiols in the Treatment of COVID-19: Current Evidence |
title_sort | use of thiols in the treatment of covid-19: current evidence |
topic | Review: Use of Thiols in Treatment of Covid-19 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390541/ https://www.ncbi.nlm.nih.gov/pubmed/34448938 http://dx.doi.org/10.1007/s00408-021-00465-3 |
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