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Helix 12 stabilization contributes to basal transcriptional activity of PXR

Pregnane X receptor (PXR) plays an important role in xenobiotic metabolism. While ligand binding induces PXR-dependent gene transcription, PXR shows constitutive transcriptional activity in the absence of ligands when expressed in cultured cells. This constitutive activity sometimes hampers investig...

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Detalles Bibliográficos
Autores principales:	Shizu, Ryota, Nishiguchi, Hikaru, Tashiro, Sarii, Sato, Takumi, Sugawara, Ayaka, Kanno, Yuichiro, Hosaka, Takuomi, Sasaki, Takamitsu, Yoshinari, Kouichi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390552/ https://www.ncbi.nlm.nih.gov/pubmed/34284062 http://dx.doi.org/10.1016/j.jbc.2021.100978

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