Cargando…

Oligodendrocytic Na(+)-K(+)-Cl(–) co-transporter 1 activity facilitates axonal conduction and restores plasticity in the adult mouse brain

The juvenile brain presents plasticity. Oligodendrocytes are the myelinating cells of the central nervous system and myelination can be adaptive. Plasticity decreases from juvenile to adulthood. The mechanisms involving oligodendrocytes underlying plasticity are unclear. Here, we show Na(+)-K(+)-Cl(...

Descripción completa

Detalles Bibliográficos
Autores principales: Yamazaki, Yoshihiko, Abe, Yoshifumi, Fujii, Satoshi, Tanaka, Kenji F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390751/
https://www.ncbi.nlm.nih.gov/pubmed/34446732
http://dx.doi.org/10.1038/s41467-021-25488-5
_version_ 1783743137954398208
author Yamazaki, Yoshihiko
Abe, Yoshifumi
Fujii, Satoshi
Tanaka, Kenji F.
author_facet Yamazaki, Yoshihiko
Abe, Yoshifumi
Fujii, Satoshi
Tanaka, Kenji F.
author_sort Yamazaki, Yoshihiko
collection PubMed
description The juvenile brain presents plasticity. Oligodendrocytes are the myelinating cells of the central nervous system and myelination can be adaptive. Plasticity decreases from juvenile to adulthood. The mechanisms involving oligodendrocytes underlying plasticity are unclear. Here, we show Na(+)-K(+)-Cl(–) co-transporter 1 (NKCC1), highly expressed in the juvenile mouse brain, regulates the oligodendrocyte activity from juvenile to adulthood in mice, as shown by optogenetic manipulation of oligodendrocytes. The reduced neuronal activity in adults was restored by Nkcc1 overexpression in oligodendrocytes. Moreover, in adult mice overexpressing Nkcc1, long-term potentiation and learning were facilitated compared to age-matched controls. These findings demonstrate that NKCC1 plays a regulatory role in the age-dependent activity of oligodendrocytes, furthermore inducing activation of NKCC1 in oligodendrocytes can restore neuronal plasticity in the adult mouse brain.
format Online
Article
Text
id pubmed-8390751
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-83907512021-09-22 Oligodendrocytic Na(+)-K(+)-Cl(–) co-transporter 1 activity facilitates axonal conduction and restores plasticity in the adult mouse brain Yamazaki, Yoshihiko Abe, Yoshifumi Fujii, Satoshi Tanaka, Kenji F. Nat Commun Article The juvenile brain presents plasticity. Oligodendrocytes are the myelinating cells of the central nervous system and myelination can be adaptive. Plasticity decreases from juvenile to adulthood. The mechanisms involving oligodendrocytes underlying plasticity are unclear. Here, we show Na(+)-K(+)-Cl(–) co-transporter 1 (NKCC1), highly expressed in the juvenile mouse brain, regulates the oligodendrocyte activity from juvenile to adulthood in mice, as shown by optogenetic manipulation of oligodendrocytes. The reduced neuronal activity in adults was restored by Nkcc1 overexpression in oligodendrocytes. Moreover, in adult mice overexpressing Nkcc1, long-term potentiation and learning were facilitated compared to age-matched controls. These findings demonstrate that NKCC1 plays a regulatory role in the age-dependent activity of oligodendrocytes, furthermore inducing activation of NKCC1 in oligodendrocytes can restore neuronal plasticity in the adult mouse brain. Nature Publishing Group UK 2021-08-26 /pmc/articles/PMC8390751/ /pubmed/34446732 http://dx.doi.org/10.1038/s41467-021-25488-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Yamazaki, Yoshihiko
Abe, Yoshifumi
Fujii, Satoshi
Tanaka, Kenji F.
Oligodendrocytic Na(+)-K(+)-Cl(–) co-transporter 1 activity facilitates axonal conduction and restores plasticity in the adult mouse brain
title Oligodendrocytic Na(+)-K(+)-Cl(–) co-transporter 1 activity facilitates axonal conduction and restores plasticity in the adult mouse brain
title_full Oligodendrocytic Na(+)-K(+)-Cl(–) co-transporter 1 activity facilitates axonal conduction and restores plasticity in the adult mouse brain
title_fullStr Oligodendrocytic Na(+)-K(+)-Cl(–) co-transporter 1 activity facilitates axonal conduction and restores plasticity in the adult mouse brain
title_full_unstemmed Oligodendrocytic Na(+)-K(+)-Cl(–) co-transporter 1 activity facilitates axonal conduction and restores plasticity in the adult mouse brain
title_short Oligodendrocytic Na(+)-K(+)-Cl(–) co-transporter 1 activity facilitates axonal conduction and restores plasticity in the adult mouse brain
title_sort oligodendrocytic na(+)-k(+)-cl(–) co-transporter 1 activity facilitates axonal conduction and restores plasticity in the adult mouse brain
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390751/
https://www.ncbi.nlm.nih.gov/pubmed/34446732
http://dx.doi.org/10.1038/s41467-021-25488-5
work_keys_str_mv AT yamazakiyoshihiko oligodendrocyticnakclcotransporter1activityfacilitatesaxonalconductionandrestoresplasticityintheadultmousebrain
AT abeyoshifumi oligodendrocyticnakclcotransporter1activityfacilitatesaxonalconductionandrestoresplasticityintheadultmousebrain
AT fujiisatoshi oligodendrocyticnakclcotransporter1activityfacilitatesaxonalconductionandrestoresplasticityintheadultmousebrain
AT tanakakenjif oligodendrocyticnakclcotransporter1activityfacilitatesaxonalconductionandrestoresplasticityintheadultmousebrain