PTENα functions as an immune suppressor and promotes immune resistance in PTEN-mutant cancer

PTEN is frequently mutated in human cancers and PTEN mutants promote tumor progression and metastasis. PTEN mutations have been implicated in immune regulation, however, the underlying mechanism is largely unknown. Here, we report that PTENα, the isoform of PTEN, remains active in cancer bearing sto...

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Detalles Bibliográficos
Autores principales: Sun, Yizhe, Lu, Dan, Yin, Yue, Song, Jia, Liu, Yang, Hao, Wenyan, Qi, Fang, Zhang, Guangze, Zhang, Xin, Liu, Liang, Lin, Zhiqiang, Liang, Hui, Zhao, Xuyang, Jin, Yan, Yin, Yuxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390757/
https://www.ncbi.nlm.nih.gov/pubmed/34446716
http://dx.doi.org/10.1038/s41467-021-25417-6

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