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The role of basement membranes in cardiac biology and disease
Basement membranes (BMs) are highly specialised extracellular matrix (ECM) structures that within the heart underlie endothelial cells (ECs) and surround cardiomyocytes and vascular smooth muscle cells. They generate a dynamic and structurally supportive environment throughout cardiac development an...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390786/ https://www.ncbi.nlm.nih.gov/pubmed/34382650 http://dx.doi.org/10.1042/BSR20204185 |
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author | Boland, Erin Quondamatteo, Fabio Van Agtmael, Tom |
author_facet | Boland, Erin Quondamatteo, Fabio Van Agtmael, Tom |
author_sort | Boland, Erin |
collection | PubMed |
description | Basement membranes (BMs) are highly specialised extracellular matrix (ECM) structures that within the heart underlie endothelial cells (ECs) and surround cardiomyocytes and vascular smooth muscle cells. They generate a dynamic and structurally supportive environment throughout cardiac development and maturation by providing physical anchorage to the underlying interstitium, structural support to the tissue, and by influencing cell behaviour and signalling. While this provides a strong link between BM dysfunction and cardiac disease, the role of the BM in cardiac biology remains under-researched and our understanding regarding the mechanistic interplay between BM defects and their morphological and functional consequences remain important knowledge-gaps. In this review, we bring together emerging understanding of BM defects within the heart including in common cardiovascular pathologies such as contractile dysfunction and highlight some key questions that are now ready to be addressed. |
format | Online Article Text |
id | pubmed-8390786 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83907862021-09-09 The role of basement membranes in cardiac biology and disease Boland, Erin Quondamatteo, Fabio Van Agtmael, Tom Biosci Rep Cardiovascular System & Vascular Biology Basement membranes (BMs) are highly specialised extracellular matrix (ECM) structures that within the heart underlie endothelial cells (ECs) and surround cardiomyocytes and vascular smooth muscle cells. They generate a dynamic and structurally supportive environment throughout cardiac development and maturation by providing physical anchorage to the underlying interstitium, structural support to the tissue, and by influencing cell behaviour and signalling. While this provides a strong link between BM dysfunction and cardiac disease, the role of the BM in cardiac biology remains under-researched and our understanding regarding the mechanistic interplay between BM defects and their morphological and functional consequences remain important knowledge-gaps. In this review, we bring together emerging understanding of BM defects within the heart including in common cardiovascular pathologies such as contractile dysfunction and highlight some key questions that are now ready to be addressed. Portland Press Ltd. 2021-08-26 /pmc/articles/PMC8390786/ /pubmed/34382650 http://dx.doi.org/10.1042/BSR20204185 Text en © 2021 The Author(s). https://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Cardiovascular System & Vascular Biology Boland, Erin Quondamatteo, Fabio Van Agtmael, Tom The role of basement membranes in cardiac biology and disease |
title | The role of basement membranes in cardiac biology and disease |
title_full | The role of basement membranes in cardiac biology and disease |
title_fullStr | The role of basement membranes in cardiac biology and disease |
title_full_unstemmed | The role of basement membranes in cardiac biology and disease |
title_short | The role of basement membranes in cardiac biology and disease |
title_sort | role of basement membranes in cardiac biology and disease |
topic | Cardiovascular System & Vascular Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390786/ https://www.ncbi.nlm.nih.gov/pubmed/34382650 http://dx.doi.org/10.1042/BSR20204185 |
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