MWC allosteric model explains unusual hemoglobin-oxygen binding curves from sickle cell drug binding

An oxygen-affinity-modifying drug, voxelotor, has very recently been approved by the FDA for treatment of sickle cell disease. The proposed mechanism of action is by preferential binding of the drug to the R quaternary conformation, which cannot copolymerize with the T conformation to form sickle fi...

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Detalles Bibliográficos
Autores principales: Henry, Eric R., Harper, Julia, Glass, Kristen E., Metaferia, Belhu, Louis, John M., Eaton, William A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390878/
https://www.ncbi.nlm.nih.gov/pubmed/33932439
http://dx.doi.org/10.1016/j.bpj.2021.04.024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390878/
https://www.ncbi.nlm.nih.gov/pubmed/33932439
http://dx.doi.org/10.1016/j.bpj.2021.04.024

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