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MWC allosteric model explains unusual hemoglobin-oxygen binding curves from sickle cell drug binding
An oxygen-affinity-modifying drug, voxelotor, has very recently been approved by the FDA for treatment of sickle cell disease. The proposed mechanism of action is by preferential binding of the drug to the R quaternary conformation, which cannot copolymerize with the T conformation to form sickle fi...
Autores principales: | Henry, Eric R., Harper, Julia, Glass, Kristen E., Metaferia, Belhu, Louis, John M., Eaton, William A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Biophysical Society
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390878/ https://www.ncbi.nlm.nih.gov/pubmed/33932439 http://dx.doi.org/10.1016/j.bpj.2021.04.024 |
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