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Randomised controlled trial and economic evaluation of a targeted cancer awareness intervention for adults living in deprived areas of the UK
BACKGROUND: Cancer outcomes are poor in socioeconomically deprived communities, with low symptom awareness contributing to prolonged help-seeking and advanced disease. Targeted cancer awareness interventions require evaluation. METHODS: This is a randomised controlled trial involving adults aged 40+...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391006/ https://www.ncbi.nlm.nih.gov/pubmed/34453114 http://dx.doi.org/10.1038/s41416-021-01524-5 |
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author | Moriarty, Yvonne Lau, Mandy Sewell, Bernadette Trubey, Rob Quinn-Scoggins, Harriet Owen, Sioned Padgett, Louise Kolovou, Vasiliki Hepburn, Julie Buckle, Peter Playle, Rebecca Townson, Julia Robling, Michael Gilbert, Stephanie Dimitropoulou, Polyxeni Edwards, Adrian Mitchell, Caroline Matthews, Maura Smits, Stephanie Wood, Fiona Neal, Richard D. Brain, Kate |
author_facet | Moriarty, Yvonne Lau, Mandy Sewell, Bernadette Trubey, Rob Quinn-Scoggins, Harriet Owen, Sioned Padgett, Louise Kolovou, Vasiliki Hepburn, Julie Buckle, Peter Playle, Rebecca Townson, Julia Robling, Michael Gilbert, Stephanie Dimitropoulou, Polyxeni Edwards, Adrian Mitchell, Caroline Matthews, Maura Smits, Stephanie Wood, Fiona Neal, Richard D. Brain, Kate |
author_sort | Moriarty, Yvonne |
collection | PubMed |
description | BACKGROUND: Cancer outcomes are poor in socioeconomically deprived communities, with low symptom awareness contributing to prolonged help-seeking and advanced disease. Targeted cancer awareness interventions require evaluation. METHODS: This is a randomised controlled trial involving adults aged 40+ years recruited in community and healthcare settings in deprived areas of South Yorkshire and South-East Wales. Intervention: personalised behavioural advice facilitated by a trained lay advisor. Control: usual care. Follow-up at two weeks and six months post-randomisation. Primary outcome: total cancer symptom recognition score two weeks post-randomisation. RESULTS: Two hundred and thirty-four participants were randomised. The difference in total symptom recognition at two weeks [adjusted mean difference (AMD) 0.6, 95% CI: −0.03, 1.17, p = 0.06] was not statistically significant. Intervention participants reported increased symptom recognition (AMD 0.8, 95% CI: 0.18, 1.37, p = 0.01) and earlier intended presentation (AMD −2.0, 95% CI: −3.02, −0.91, p < 0.001) at six months. “Lesser known” symptom recognition was higher in the intervention arm (2 weeks AMD 0.5, 95% CI: 0.03, 0.97 and six months AMD 0.7, 95% CI: 0.16, 1.17). Implementation cost per participant was £91.34, with no significant between-group differences in healthcare resource use post-intervention. CONCLUSIONS: Improved symptom recognition and earlier anticipated presentation occurred at longer-term follow-up. The ABACus Health Check is a viable low-cost intervention to increase cancer awareness in socioeconomically deprived communities. CLINICAL TRIAL REGISTRATION: ISRCTN16872545. |
format | Online Article Text |
id | pubmed-8391006 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-83910062021-08-27 Randomised controlled trial and economic evaluation of a targeted cancer awareness intervention for adults living in deprived areas of the UK Moriarty, Yvonne Lau, Mandy Sewell, Bernadette Trubey, Rob Quinn-Scoggins, Harriet Owen, Sioned Padgett, Louise Kolovou, Vasiliki Hepburn, Julie Buckle, Peter Playle, Rebecca Townson, Julia Robling, Michael Gilbert, Stephanie Dimitropoulou, Polyxeni Edwards, Adrian Mitchell, Caroline Matthews, Maura Smits, Stephanie Wood, Fiona Neal, Richard D. Brain, Kate Br J Cancer Article BACKGROUND: Cancer outcomes are poor in socioeconomically deprived communities, with low symptom awareness contributing to prolonged help-seeking and advanced disease. Targeted cancer awareness interventions require evaluation. METHODS: This is a randomised controlled trial involving adults aged 40+ years recruited in community and healthcare settings in deprived areas of South Yorkshire and South-East Wales. Intervention: personalised behavioural advice facilitated by a trained lay advisor. Control: usual care. Follow-up at two weeks and six months post-randomisation. Primary outcome: total cancer symptom recognition score two weeks post-randomisation. RESULTS: Two hundred and thirty-four participants were randomised. The difference in total symptom recognition at two weeks [adjusted mean difference (AMD) 0.6, 95% CI: −0.03, 1.17, p = 0.06] was not statistically significant. Intervention participants reported increased symptom recognition (AMD 0.8, 95% CI: 0.18, 1.37, p = 0.01) and earlier intended presentation (AMD −2.0, 95% CI: −3.02, −0.91, p < 0.001) at six months. “Lesser known” symptom recognition was higher in the intervention arm (2 weeks AMD 0.5, 95% CI: 0.03, 0.97 and six months AMD 0.7, 95% CI: 0.16, 1.17). Implementation cost per participant was £91.34, with no significant between-group differences in healthcare resource use post-intervention. CONCLUSIONS: Improved symptom recognition and earlier anticipated presentation occurred at longer-term follow-up. The ABACus Health Check is a viable low-cost intervention to increase cancer awareness in socioeconomically deprived communities. CLINICAL TRIAL REGISTRATION: ISRCTN16872545. Nature Publishing Group UK 2021-08-27 2021-10-12 /pmc/articles/PMC8391006/ /pubmed/34453114 http://dx.doi.org/10.1038/s41416-021-01524-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Moriarty, Yvonne Lau, Mandy Sewell, Bernadette Trubey, Rob Quinn-Scoggins, Harriet Owen, Sioned Padgett, Louise Kolovou, Vasiliki Hepburn, Julie Buckle, Peter Playle, Rebecca Townson, Julia Robling, Michael Gilbert, Stephanie Dimitropoulou, Polyxeni Edwards, Adrian Mitchell, Caroline Matthews, Maura Smits, Stephanie Wood, Fiona Neal, Richard D. Brain, Kate Randomised controlled trial and economic evaluation of a targeted cancer awareness intervention for adults living in deprived areas of the UK |
title | Randomised controlled trial and economic evaluation of a targeted cancer awareness intervention for adults living in deprived areas of the UK |
title_full | Randomised controlled trial and economic evaluation of a targeted cancer awareness intervention for adults living in deprived areas of the UK |
title_fullStr | Randomised controlled trial and economic evaluation of a targeted cancer awareness intervention for adults living in deprived areas of the UK |
title_full_unstemmed | Randomised controlled trial and economic evaluation of a targeted cancer awareness intervention for adults living in deprived areas of the UK |
title_short | Randomised controlled trial and economic evaluation of a targeted cancer awareness intervention for adults living in deprived areas of the UK |
title_sort | randomised controlled trial and economic evaluation of a targeted cancer awareness intervention for adults living in deprived areas of the uk |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391006/ https://www.ncbi.nlm.nih.gov/pubmed/34453114 http://dx.doi.org/10.1038/s41416-021-01524-5 |
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