The Role of the Hedgehog Pathway in Chemoresistance of Gastrointestinal Cancers

The hedgehog pathway, which plays a significant role in embryonic development and stem cell regulation, is activated in gastrointestinal cancers. Chemotherapy is widely used in cancer treatment. However, chemoresistance becomes a substantial obstacle in cancer therapy. This review focuses on the rec...

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Detalles Bibliográficos
Autores principales: Liang, Yabing, Yang, Ling, Xie, Jingwu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391142/
https://www.ncbi.nlm.nih.gov/pubmed/34440799
http://dx.doi.org/10.3390/cells10082030
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author Liang, Yabing
Yang, Ling
Xie, Jingwu
author_facet Liang, Yabing
Yang, Ling
Xie, Jingwu
author_sort Liang, Yabing
collection PubMed
description The hedgehog pathway, which plays a significant role in embryonic development and stem cell regulation, is activated in gastrointestinal cancers. Chemotherapy is widely used in cancer treatment. However, chemoresistance becomes a substantial obstacle in cancer therapy. This review focuses on the recent advances in the hedgehog pathway’s roles in drug resistance of gastrointestinal cancers and the novel drugs and strategies targeting hedgehog signaling.
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spelling pubmed-83911422021-08-28 The Role of the Hedgehog Pathway in Chemoresistance of Gastrointestinal Cancers Liang, Yabing Yang, Ling Xie, Jingwu Cells Review The hedgehog pathway, which plays a significant role in embryonic development and stem cell regulation, is activated in gastrointestinal cancers. Chemotherapy is widely used in cancer treatment. However, chemoresistance becomes a substantial obstacle in cancer therapy. This review focuses on the recent advances in the hedgehog pathway’s roles in drug resistance of gastrointestinal cancers and the novel drugs and strategies targeting hedgehog signaling. MDPI 2021-08-09 /pmc/articles/PMC8391142/ /pubmed/34440799 http://dx.doi.org/10.3390/cells10082030 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Liang, Yabing
Yang, Ling
Xie, Jingwu
The Role of the Hedgehog Pathway in Chemoresistance of Gastrointestinal Cancers
title The Role of the Hedgehog Pathway in Chemoresistance of Gastrointestinal Cancers
title_full The Role of the Hedgehog Pathway in Chemoresistance of Gastrointestinal Cancers
title_fullStr The Role of the Hedgehog Pathway in Chemoresistance of Gastrointestinal Cancers
title_full_unstemmed The Role of the Hedgehog Pathway in Chemoresistance of Gastrointestinal Cancers
title_short The Role of the Hedgehog Pathway in Chemoresistance of Gastrointestinal Cancers
title_sort role of the hedgehog pathway in chemoresistance of gastrointestinal cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391142/
https://www.ncbi.nlm.nih.gov/pubmed/34440799
http://dx.doi.org/10.3390/cells10082030
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