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May the Force Be with You (Or Not): The Immune System under Microgravity

All terrestrial organisms have evolved and adapted to thrive under Earth’s gravitational force. Due to the increase of crewed space flights in recent years, it is vital to understand how the lack of gravitational forces affects organisms. It is known that astronauts who have been exposed to microgra...

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Detalles Bibliográficos
Autores principales: ElGindi, Mei, Sapudom, Jiranuwat, Ibrahim, Ibrahim Hamed, Al-Sayegh, Mohamed, Chen, Weiqiang, Garcia-Sabaté, Anna, Teo, Jeremy C. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391211/
https://www.ncbi.nlm.nih.gov/pubmed/34440709
http://dx.doi.org/10.3390/cells10081941
Descripción
Sumario:All terrestrial organisms have evolved and adapted to thrive under Earth’s gravitational force. Due to the increase of crewed space flights in recent years, it is vital to understand how the lack of gravitational forces affects organisms. It is known that astronauts who have been exposed to microgravity suffer from an array of pathological conditions including an impaired immune system, which is one of the most negatively affected by microgravity. However, at the cellular level a gap in knowledge exists, limiting our ability to understand immune impairment in space. This review highlights the most significant work done over the past 10 years detailing the effects of microgravity on cellular aspects of the immune system.