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May the Force Be with You (Or Not): The Immune System under Microgravity

All terrestrial organisms have evolved and adapted to thrive under Earth’s gravitational force. Due to the increase of crewed space flights in recent years, it is vital to understand how the lack of gravitational forces affects organisms. It is known that astronauts who have been exposed to microgra...

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Detalles Bibliográficos
Autores principales: ElGindi, Mei, Sapudom, Jiranuwat, Ibrahim, Ibrahim Hamed, Al-Sayegh, Mohamed, Chen, Weiqiang, Garcia-Sabaté, Anna, Teo, Jeremy C. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391211/
https://www.ncbi.nlm.nih.gov/pubmed/34440709
http://dx.doi.org/10.3390/cells10081941
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author ElGindi, Mei
Sapudom, Jiranuwat
Ibrahim, Ibrahim Hamed
Al-Sayegh, Mohamed
Chen, Weiqiang
Garcia-Sabaté, Anna
Teo, Jeremy C. M.
author_facet ElGindi, Mei
Sapudom, Jiranuwat
Ibrahim, Ibrahim Hamed
Al-Sayegh, Mohamed
Chen, Weiqiang
Garcia-Sabaté, Anna
Teo, Jeremy C. M.
author_sort ElGindi, Mei
collection PubMed
description All terrestrial organisms have evolved and adapted to thrive under Earth’s gravitational force. Due to the increase of crewed space flights in recent years, it is vital to understand how the lack of gravitational forces affects organisms. It is known that astronauts who have been exposed to microgravity suffer from an array of pathological conditions including an impaired immune system, which is one of the most negatively affected by microgravity. However, at the cellular level a gap in knowledge exists, limiting our ability to understand immune impairment in space. This review highlights the most significant work done over the past 10 years detailing the effects of microgravity on cellular aspects of the immune system.
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spelling pubmed-83912112021-08-28 May the Force Be with You (Or Not): The Immune System under Microgravity ElGindi, Mei Sapudom, Jiranuwat Ibrahim, Ibrahim Hamed Al-Sayegh, Mohamed Chen, Weiqiang Garcia-Sabaté, Anna Teo, Jeremy C. M. Cells Review All terrestrial organisms have evolved and adapted to thrive under Earth’s gravitational force. Due to the increase of crewed space flights in recent years, it is vital to understand how the lack of gravitational forces affects organisms. It is known that astronauts who have been exposed to microgravity suffer from an array of pathological conditions including an impaired immune system, which is one of the most negatively affected by microgravity. However, at the cellular level a gap in knowledge exists, limiting our ability to understand immune impairment in space. This review highlights the most significant work done over the past 10 years detailing the effects of microgravity on cellular aspects of the immune system. MDPI 2021-07-30 /pmc/articles/PMC8391211/ /pubmed/34440709 http://dx.doi.org/10.3390/cells10081941 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
ElGindi, Mei
Sapudom, Jiranuwat
Ibrahim, Ibrahim Hamed
Al-Sayegh, Mohamed
Chen, Weiqiang
Garcia-Sabaté, Anna
Teo, Jeremy C. M.
May the Force Be with You (Or Not): The Immune System under Microgravity
title May the Force Be with You (Or Not): The Immune System under Microgravity
title_full May the Force Be with You (Or Not): The Immune System under Microgravity
title_fullStr May the Force Be with You (Or Not): The Immune System under Microgravity
title_full_unstemmed May the Force Be with You (Or Not): The Immune System under Microgravity
title_short May the Force Be with You (Or Not): The Immune System under Microgravity
title_sort may the force be with you (or not): the immune system under microgravity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391211/
https://www.ncbi.nlm.nih.gov/pubmed/34440709
http://dx.doi.org/10.3390/cells10081941
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