Non-Canonical Role of PDK1 as a Negative Regulator of Apoptosis through Macromolecular Complexes Assembly at the ER–Mitochondria Interface in Oncogene-Driven NSCLC

SIMPLE SUMMARY: Co-targeting of glucose metabolism and oncogene drivers in patients with non-small cell lung cancer (NSCLC) has been proposed as a potentially effective therapeutic strategy. Here, we demonstrate that downregulation of pyruvate dehydrogenase kinase 1 (PDK1), an enzyme of glycolytic c...

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Detalles Bibliográficos
Autores principales: De Rosa, Viviana, Iommelli, Francesca, Terlizzi, Cristina, Leggiero, Eleonora, Camerlingo, Rosa, Altobelli, Giovanna G., Fonti, Rosa, Pastore, Lucio, Del Vecchio, Silvana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391251/
https://www.ncbi.nlm.nih.gov/pubmed/34439291
http://dx.doi.org/10.3390/cancers13164133

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