Cargando…

Perioperative Glial Fibrillary Acidic Protein Is Associated with Long-Term Neurodevelopment Outcome of Infants with Congenital Heart Disease

Background: Brain injury, impaired brain maturation, and long-term neurodevelopmental disorders are common in infants with congenital heart diseases (CHD). We aimed to assess whether plasma glial fibrillary acidic protein (GFAP) can predict neurodevelopmental anomalies in CHD infants operated on car...

Descripción completa

Detalles Bibliográficos
Autores principales: Vergine, Michela, Vedovelli, Luca, Simonato, Manuela, Tonazzo, Valentina, Correani, Alessio, Cainelli, Elisa, Gregori, Dario, Padalino, Massimo A., Cogo, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391328/
https://www.ncbi.nlm.nih.gov/pubmed/34438546
http://dx.doi.org/10.3390/children8080655
_version_ 1783743249276469248
author Vergine, Michela
Vedovelli, Luca
Simonato, Manuela
Tonazzo, Valentina
Correani, Alessio
Cainelli, Elisa
Gregori, Dario
Padalino, Massimo A.
Cogo, Paola
author_facet Vergine, Michela
Vedovelli, Luca
Simonato, Manuela
Tonazzo, Valentina
Correani, Alessio
Cainelli, Elisa
Gregori, Dario
Padalino, Massimo A.
Cogo, Paola
author_sort Vergine, Michela
collection PubMed
description Background: Brain injury, impaired brain maturation, and long-term neurodevelopmental disorders are common in infants with congenital heart diseases (CHD). We aimed to assess whether plasma glial fibrillary acidic protein (GFAP) can predict neurodevelopmental anomalies in CHD infants operated on cardiopulmonary bypass (CPB). Methods: We measured plasma GFAP in 38 infants at multiple CPB phases. Cognitive, neuropsychological, and psychopathological functioning were assessed 5.7 ± 2.2 years after surgery. We identified an impaired global neurodevelopmental index (NDI) when at least two domains were abnormal. The relationships between NDI, GFAP, and clinical variables were explored with non-supervised feature selection methods and modeled with a nested non-linear logistic regression. Results: Intelligence quotient scores were within the normal range in 84% of children, whereas 58% showed an abnormal NDI, with the greatest impairments in the psychopathological area. The plasma GFAP peak was 0.95 (0.44–1.57) ng/mL, and it was correlated with age, weight, duration of surgery phases, and CPB minimum temperature. In the regression model, the GFAP peak was associated with an impaired NDI with a possible flexible point toward NDI impairment at 0.49 ng/mL, keeping constant ICU stay, CPB duration, CHD anatomy, weight, and CPB minimum temperature. Conclusion: GFAP is a promising early marker of abnormal long-term neuropsychological development.
format Online
Article
Text
id pubmed-8391328
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-83913282021-08-28 Perioperative Glial Fibrillary Acidic Protein Is Associated with Long-Term Neurodevelopment Outcome of Infants with Congenital Heart Disease Vergine, Michela Vedovelli, Luca Simonato, Manuela Tonazzo, Valentina Correani, Alessio Cainelli, Elisa Gregori, Dario Padalino, Massimo A. Cogo, Paola Children (Basel) Article Background: Brain injury, impaired brain maturation, and long-term neurodevelopmental disorders are common in infants with congenital heart diseases (CHD). We aimed to assess whether plasma glial fibrillary acidic protein (GFAP) can predict neurodevelopmental anomalies in CHD infants operated on cardiopulmonary bypass (CPB). Methods: We measured plasma GFAP in 38 infants at multiple CPB phases. Cognitive, neuropsychological, and psychopathological functioning were assessed 5.7 ± 2.2 years after surgery. We identified an impaired global neurodevelopmental index (NDI) when at least two domains were abnormal. The relationships between NDI, GFAP, and clinical variables were explored with non-supervised feature selection methods and modeled with a nested non-linear logistic regression. Results: Intelligence quotient scores were within the normal range in 84% of children, whereas 58% showed an abnormal NDI, with the greatest impairments in the psychopathological area. The plasma GFAP peak was 0.95 (0.44–1.57) ng/mL, and it was correlated with age, weight, duration of surgery phases, and CPB minimum temperature. In the regression model, the GFAP peak was associated with an impaired NDI with a possible flexible point toward NDI impairment at 0.49 ng/mL, keeping constant ICU stay, CPB duration, CHD anatomy, weight, and CPB minimum temperature. Conclusion: GFAP is a promising early marker of abnormal long-term neuropsychological development. MDPI 2021-07-29 /pmc/articles/PMC8391328/ /pubmed/34438546 http://dx.doi.org/10.3390/children8080655 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Vergine, Michela
Vedovelli, Luca
Simonato, Manuela
Tonazzo, Valentina
Correani, Alessio
Cainelli, Elisa
Gregori, Dario
Padalino, Massimo A.
Cogo, Paola
Perioperative Glial Fibrillary Acidic Protein Is Associated with Long-Term Neurodevelopment Outcome of Infants with Congenital Heart Disease
title Perioperative Glial Fibrillary Acidic Protein Is Associated with Long-Term Neurodevelopment Outcome of Infants with Congenital Heart Disease
title_full Perioperative Glial Fibrillary Acidic Protein Is Associated with Long-Term Neurodevelopment Outcome of Infants with Congenital Heart Disease
title_fullStr Perioperative Glial Fibrillary Acidic Protein Is Associated with Long-Term Neurodevelopment Outcome of Infants with Congenital Heart Disease
title_full_unstemmed Perioperative Glial Fibrillary Acidic Protein Is Associated with Long-Term Neurodevelopment Outcome of Infants with Congenital Heart Disease
title_short Perioperative Glial Fibrillary Acidic Protein Is Associated with Long-Term Neurodevelopment Outcome of Infants with Congenital Heart Disease
title_sort perioperative glial fibrillary acidic protein is associated with long-term neurodevelopment outcome of infants with congenital heart disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391328/
https://www.ncbi.nlm.nih.gov/pubmed/34438546
http://dx.doi.org/10.3390/children8080655
work_keys_str_mv AT verginemichela perioperativeglialfibrillaryacidicproteinisassociatedwithlongtermneurodevelopmentoutcomeofinfantswithcongenitalheartdisease
AT vedovelliluca perioperativeglialfibrillaryacidicproteinisassociatedwithlongtermneurodevelopmentoutcomeofinfantswithcongenitalheartdisease
AT simonatomanuela perioperativeglialfibrillaryacidicproteinisassociatedwithlongtermneurodevelopmentoutcomeofinfantswithcongenitalheartdisease
AT tonazzovalentina perioperativeglialfibrillaryacidicproteinisassociatedwithlongtermneurodevelopmentoutcomeofinfantswithcongenitalheartdisease
AT correanialessio perioperativeglialfibrillaryacidicproteinisassociatedwithlongtermneurodevelopmentoutcomeofinfantswithcongenitalheartdisease
AT cainellielisa perioperativeglialfibrillaryacidicproteinisassociatedwithlongtermneurodevelopmentoutcomeofinfantswithcongenitalheartdisease
AT gregoridario perioperativeglialfibrillaryacidicproteinisassociatedwithlongtermneurodevelopmentoutcomeofinfantswithcongenitalheartdisease
AT padalinomassimoa perioperativeglialfibrillaryacidicproteinisassociatedwithlongtermneurodevelopmentoutcomeofinfantswithcongenitalheartdisease
AT cogopaola perioperativeglialfibrillaryacidicproteinisassociatedwithlongtermneurodevelopmentoutcomeofinfantswithcongenitalheartdisease