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Plectin-Mediated Intermediate Filament Functions: Why Isoforms Matter

This essay focuses on the role of plectin and its various isoforms in mediating intermediate filament (IF) network functions. It is based on previous studies that provided comprehensive evidence for a concept where plectin acts as an IF recruiter, and plectin-mediated IF networking and anchoring are...

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Detalles Bibliográficos
Autor principal: Wiche, Gerhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391331/
https://www.ncbi.nlm.nih.gov/pubmed/34440923
http://dx.doi.org/10.3390/cells10082154
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author Wiche, Gerhard
author_facet Wiche, Gerhard
author_sort Wiche, Gerhard
collection PubMed
description This essay focuses on the role of plectin and its various isoforms in mediating intermediate filament (IF) network functions. It is based on previous studies that provided comprehensive evidence for a concept where plectin acts as an IF recruiter, and plectin-mediated IF networking and anchoring are key elements in IF function execution. Here, plectin’s global role as modulator of IF functionality is viewed from different perspectives, including the mechanical stabilization of IF networks and their docking platforms, contribution to cellular viscoelasticity and mechanotransduction, compartmentalization and control of the actomyosin machinery, connections to the microtubule system, and mechanisms and specificity of isoform targeting. Arguments for IF networks and plectin acting as mutually dependent partners are also given. Lastly, a working model is presented that describes a unifying mechanism underlying how plectin–IF networks mechanically control and propagate actomyosin-generated forces, affect microtubule dynamics, and contribute to mechanotransduction.
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spelling pubmed-83913312021-08-28 Plectin-Mediated Intermediate Filament Functions: Why Isoforms Matter Wiche, Gerhard Cells Review This essay focuses on the role of plectin and its various isoforms in mediating intermediate filament (IF) network functions. It is based on previous studies that provided comprehensive evidence for a concept where plectin acts as an IF recruiter, and plectin-mediated IF networking and anchoring are key elements in IF function execution. Here, plectin’s global role as modulator of IF functionality is viewed from different perspectives, including the mechanical stabilization of IF networks and their docking platforms, contribution to cellular viscoelasticity and mechanotransduction, compartmentalization and control of the actomyosin machinery, connections to the microtubule system, and mechanisms and specificity of isoform targeting. Arguments for IF networks and plectin acting as mutually dependent partners are also given. Lastly, a working model is presented that describes a unifying mechanism underlying how plectin–IF networks mechanically control and propagate actomyosin-generated forces, affect microtubule dynamics, and contribute to mechanotransduction. MDPI 2021-08-21 /pmc/articles/PMC8391331/ /pubmed/34440923 http://dx.doi.org/10.3390/cells10082154 Text en © 2021 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wiche, Gerhard
Plectin-Mediated Intermediate Filament Functions: Why Isoforms Matter
title Plectin-Mediated Intermediate Filament Functions: Why Isoforms Matter
title_full Plectin-Mediated Intermediate Filament Functions: Why Isoforms Matter
title_fullStr Plectin-Mediated Intermediate Filament Functions: Why Isoforms Matter
title_full_unstemmed Plectin-Mediated Intermediate Filament Functions: Why Isoforms Matter
title_short Plectin-Mediated Intermediate Filament Functions: Why Isoforms Matter
title_sort plectin-mediated intermediate filament functions: why isoforms matter
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391331/
https://www.ncbi.nlm.nih.gov/pubmed/34440923
http://dx.doi.org/10.3390/cells10082154
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