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Oxidative Stress Induces Telomere Dysfunction and Shortening in Human Oocytes of Advanced Age Donors
Research from the past decades provided strong evidence that in humans the pool of oocytes starts to decline already before the birth of a female individual, and from menarche to menopause the oocyte is exposed to different environmental stimuli. Since more and more women of the 21st century in deve...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391391/ https://www.ncbi.nlm.nih.gov/pubmed/34440635 http://dx.doi.org/10.3390/cells10081866 |
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author | Kordowitzki, Paweł |
author_facet | Kordowitzki, Paweł |
author_sort | Kordowitzki, Paweł |
collection | PubMed |
description | Research from the past decades provided strong evidence that in humans the pool of oocytes starts to decline already before the birth of a female individual, and from menarche to menopause the oocyte is exposed to different environmental stimuli. Since more and more women of the 21st century in developed countries wish to postpone the first pregnancy to their thirties, higher rates of miscarriage and chromosomal non-disjunction might occur. In oocytes of advanced maternal age, meaning above 35 years of age, characteristics such as chromosomal instabilities/abnormalities, spindle defects, decreased mitochondrial function and telomere shortening become more prevalent than in younger counterparts. Telomere attrition belongs to the so-called “hallmarks of aging” which are also relevant for the female germ-line cells. In oocytes, telomeres shorten with advancing maternal age due to the effects of reactive oxygen species and not upon replicative senescence, similar to how it is common in dividing cells. |
format | Online Article Text |
id | pubmed-8391391 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83913912021-08-28 Oxidative Stress Induces Telomere Dysfunction and Shortening in Human Oocytes of Advanced Age Donors Kordowitzki, Paweł Cells Commentary Research from the past decades provided strong evidence that in humans the pool of oocytes starts to decline already before the birth of a female individual, and from menarche to menopause the oocyte is exposed to different environmental stimuli. Since more and more women of the 21st century in developed countries wish to postpone the first pregnancy to their thirties, higher rates of miscarriage and chromosomal non-disjunction might occur. In oocytes of advanced maternal age, meaning above 35 years of age, characteristics such as chromosomal instabilities/abnormalities, spindle defects, decreased mitochondrial function and telomere shortening become more prevalent than in younger counterparts. Telomere attrition belongs to the so-called “hallmarks of aging” which are also relevant for the female germ-line cells. In oocytes, telomeres shorten with advancing maternal age due to the effects of reactive oxygen species and not upon replicative senescence, similar to how it is common in dividing cells. MDPI 2021-07-23 /pmc/articles/PMC8391391/ /pubmed/34440635 http://dx.doi.org/10.3390/cells10081866 Text en © 2021 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Commentary Kordowitzki, Paweł Oxidative Stress Induces Telomere Dysfunction and Shortening in Human Oocytes of Advanced Age Donors |
title | Oxidative Stress Induces Telomere Dysfunction and Shortening in Human Oocytes of Advanced Age Donors |
title_full | Oxidative Stress Induces Telomere Dysfunction and Shortening in Human Oocytes of Advanced Age Donors |
title_fullStr | Oxidative Stress Induces Telomere Dysfunction and Shortening in Human Oocytes of Advanced Age Donors |
title_full_unstemmed | Oxidative Stress Induces Telomere Dysfunction and Shortening in Human Oocytes of Advanced Age Donors |
title_short | Oxidative Stress Induces Telomere Dysfunction and Shortening in Human Oocytes of Advanced Age Donors |
title_sort | oxidative stress induces telomere dysfunction and shortening in human oocytes of advanced age donors |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391391/ https://www.ncbi.nlm.nih.gov/pubmed/34440635 http://dx.doi.org/10.3390/cells10081866 |
work_keys_str_mv | AT kordowitzkipaweł oxidativestressinducestelomeredysfunctionandshorteninginhumanoocytesofadvancedagedonors |