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Oxidative Stress Induces Telomere Dysfunction and Shortening in Human Oocytes of Advanced Age Donors

Research from the past decades provided strong evidence that in humans the pool of oocytes starts to decline already before the birth of a female individual, and from menarche to menopause the oocyte is exposed to different environmental stimuli. Since more and more women of the 21st century in deve...

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Autor principal: Kordowitzki, Paweł
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391391/
https://www.ncbi.nlm.nih.gov/pubmed/34440635
http://dx.doi.org/10.3390/cells10081866
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author Kordowitzki, Paweł
author_facet Kordowitzki, Paweł
author_sort Kordowitzki, Paweł
collection PubMed
description Research from the past decades provided strong evidence that in humans the pool of oocytes starts to decline already before the birth of a female individual, and from menarche to menopause the oocyte is exposed to different environmental stimuli. Since more and more women of the 21st century in developed countries wish to postpone the first pregnancy to their thirties, higher rates of miscarriage and chromosomal non-disjunction might occur. In oocytes of advanced maternal age, meaning above 35 years of age, characteristics such as chromosomal instabilities/abnormalities, spindle defects, decreased mitochondrial function and telomere shortening become more prevalent than in younger counterparts. Telomere attrition belongs to the so-called “hallmarks of aging” which are also relevant for the female germ-line cells. In oocytes, telomeres shorten with advancing maternal age due to the effects of reactive oxygen species and not upon replicative senescence, similar to how it is common in dividing cells.
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spelling pubmed-83913912021-08-28 Oxidative Stress Induces Telomere Dysfunction and Shortening in Human Oocytes of Advanced Age Donors Kordowitzki, Paweł Cells Commentary Research from the past decades provided strong evidence that in humans the pool of oocytes starts to decline already before the birth of a female individual, and from menarche to menopause the oocyte is exposed to different environmental stimuli. Since more and more women of the 21st century in developed countries wish to postpone the first pregnancy to their thirties, higher rates of miscarriage and chromosomal non-disjunction might occur. In oocytes of advanced maternal age, meaning above 35 years of age, characteristics such as chromosomal instabilities/abnormalities, spindle defects, decreased mitochondrial function and telomere shortening become more prevalent than in younger counterparts. Telomere attrition belongs to the so-called “hallmarks of aging” which are also relevant for the female germ-line cells. In oocytes, telomeres shorten with advancing maternal age due to the effects of reactive oxygen species and not upon replicative senescence, similar to how it is common in dividing cells. MDPI 2021-07-23 /pmc/articles/PMC8391391/ /pubmed/34440635 http://dx.doi.org/10.3390/cells10081866 Text en © 2021 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Commentary
Kordowitzki, Paweł
Oxidative Stress Induces Telomere Dysfunction and Shortening in Human Oocytes of Advanced Age Donors
title Oxidative Stress Induces Telomere Dysfunction and Shortening in Human Oocytes of Advanced Age Donors
title_full Oxidative Stress Induces Telomere Dysfunction and Shortening in Human Oocytes of Advanced Age Donors
title_fullStr Oxidative Stress Induces Telomere Dysfunction and Shortening in Human Oocytes of Advanced Age Donors
title_full_unstemmed Oxidative Stress Induces Telomere Dysfunction and Shortening in Human Oocytes of Advanced Age Donors
title_short Oxidative Stress Induces Telomere Dysfunction and Shortening in Human Oocytes of Advanced Age Donors
title_sort oxidative stress induces telomere dysfunction and shortening in human oocytes of advanced age donors
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391391/
https://www.ncbi.nlm.nih.gov/pubmed/34440635
http://dx.doi.org/10.3390/cells10081866
work_keys_str_mv AT kordowitzkipaweł oxidativestressinducestelomeredysfunctionandshorteninginhumanoocytesofadvancedagedonors