Cargando…

Thermodynamic Genome-Scale Metabolic Modeling of Metallodrug Resistance in Colorectal Cancer

SIMPLE SUMMARY: Cancer, but also its treatment, can lead to a reprogramming of cellular metabolism. These changes are observable in metabolite abundances, which can be unbiasedly measured via mass spectrometry metabolomics. However, even when the metabolome changes strongly, a (mechanistic) interpre...

Descripción completa

Detalles Bibliográficos
Autores principales:	Herrmann, Helena A., Rusz, Mate, Baier, Dina, Jakupec, Michael A., Keppler, Bernhard K., Berger, Walter, Koellensperger, Gunda, Zanghellini, Jürgen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391396/ https://www.ncbi.nlm.nih.gov/pubmed/34439283 http://dx.doi.org/10.3390/cancers13164130

Ejemplares similares

Single Spheroid Metabolomics: Optimizing Sample Preparation of Three-Dimensional Multicellular Tumor Spheroids
por: Rusz, Mate, et al.
Publicado: (2019)

Critical assessment of different methods for quantitative measurement of metallodrug-protein associations
por: Galvez, Luis, et al.
Publicado: (2018)

Morpho‐metabotyping the oxidative stress response
por: Rusz, Mate, et al.
Publicado: (2021)

Interaction with Ribosomal Proteins Accompanies Stress Induction of the Anticancer Metallodrug BOLD‐100/KP1339 in the Endoplasmic Reticulum
por: Neuditschko, Benjamin, et al.
Publicado: (2021)

The Anticancer Ruthenium Compound BOLD-100 Targets Glycolysis and Generates a Metabolic Vulnerability towards Glucose Deprivation
por: Baier, Dina, et al.
Publicado: (2022)

The Lipid Metabolism as Target and Modulator of BOLD‐100 Anticancer Activity: Crosstalk with Histone Acetylation
por: Baier, Dina, et al.
Publicado: (2023)

Multiparametric Tissue Characterization Utilizing the Cellular Metallome and Immuno-Mass Spectrometry Imaging
por: Schaier, Martin, et al.
Publicado: (2023)

Power of mzRAPP-Based Performance Assessments in MS1-Based Nontargeted Feature Detection
por: El Abiead, Yasin, et al.
Publicado: (2022)

Comprehensive assessment of measurement uncertainty in (13)C-based metabolic flux experiments
por: Mairinger, Teresa, et al.
Publicado: (2018)

Recurrent Topics in Mass Spectrometry-Based Metabolomics and Lipidomics—Standardization, Coverage, and Throughput
por: Rampler, Evelyn, et al.
Publicado: (2020)

Target-directed catalytic metallodrugs
por: Joyner, J.C., et al.
Publicado: (2013)

Ruthenacarborane–Phenanthroline Derivatives as Potential Metallodrugs
por: Kellert, Martin, et al.
Publicado: (2020)

NKP-1339, a first-in-class anticancer drug showing mild side effects and activity in patients suffering from advanced refractory cancer
por: Trondl, Robert, et al.
Publicado: (2012)

Impact of terminal dimethylation on the resistance profile of α-N-heterocyclic thiosemicarbazones
por: Heffeter, Petra, et al.
Publicado: (2012)

The Power of LC-MS Based Multiomics: Exploring Adipogenic Differentiation of Human Mesenchymal Stem/Stromal Cells
por: Rampler, Evelyn, et al.
Publicado: (2019)

The ruthenium compound KP1339 potentiates the anticancer activity of sorafenib in vitro and in vivo()
por: Heffeter, Petra, et al.
Publicado: (2013)

Comparison of metabolic pathways of different α-N-heterocyclic thiosemicarbazones
por: Pelivan, Karla, et al.
Publicado: (2018)

Anticancer Tungstenocenes with a Diverse Set of (O,O–), (O,S–) and (O,N–) Chelates—A Detailed Biological Study Using an Improved Evaluation via 3D Spheroid Models
por: Cseh, Klaudia, et al.
Publicado: (2023)

Serum-binding properties of isosteric ruthenium and osmium anticancer agents elucidated by SEC–ICP–MS
por: Klose, Matthias H. M., et al.
Publicado: (2018)

Metallodrugs are unique: opportunities and challenges of discovery and development
por: Anthony, Elizabeth J., et al.
Publicado: (2020)

Synthesis, Modification, and Biological Evaluation of a Library of Novel Water‐Soluble Thiopyridone‐Based Organometallic Complexes and Their Unexpected (Biological) Behavior
por: Harringer, Sophia, et al.
Publicado: (2020)

An albumin-based tumor-targeted oxaliplatin prodrug with distinctly improved anticancer activity in vivo
por: Mayr, Josef, et al.
Publicado: (2017)

Homologue series detection and management in LC-MS data with homologueDiscoverer
por: Mildau, Kevin, et al.
Publicado: (2022)

DNA-Metallodrugs Interactions Signaled by Electrochemical Biosensors: An Overview
por: Ravera, Mauro, et al.
Publicado: (2007)

Metallodrugs: an approach against invasion and metastasis in cancer treatment
por: González‐Ballesteros, Mauricio M., et al.
Publicado: (2022)

Metallodrugs: Mechanisms of Action, Molecular Targets and Biological Activity
por: Ferraro, Giarita, et al.
Publicado: (2022)

New Copper-Based Metallodrugs with Anti-Invasive Capacity
por: Garufi, Alessia, et al.
Publicado: (2023)

Cancer 3D Models for Metallodrug Preclinical Testing
por: Engrácia, Diogo M., et al.
Publicado: (2023)

Which sets of elementary flux modes form thermodynamically feasible flux distributions?
por: Gerstl, Matthias P., et al.
Publicado: (2016)

Micro-droplet-based calibration for quantitative elemental bioimaging by LA-ICPMS
por: Schweikert, Andreas, et al.
Publicado: (2021)

Molecular methods for assessment of non-covalent metallodrug–DNA interactions
por: Kellett, Andrew, et al.
Publicado: (2019)

Polyoxometalates as Potential Next‐Generation Metallodrugs in the Combat Against Cancer
por: Bijelic, Aleksandar, et al.
Publicado: (2018)

Cellular Transport Mechanisms of Cytotoxic Metallodrugs: An Overview beyond Cisplatin
por: Spreckelmeyer, Sarah, et al.
Publicado: (2014)

Combination of Drug Delivery Properties of PAMAM Dendrimers and Cytotoxicity of Platinum(IV) Complexes—A More Selective Anticancer Treatment?
por: Lerchbammer-Kreith, Yvonne, et al.
Publicado: (2023)

Expression proteomics study to determine metallodrug targets and optimal drug combinations
por: Lee, Ronald F. S., et al.
Publicado: (2017)

The impact of whole human blood on the kinetic inertness of platinum(iv) prodrugs – an HPLC-ICP-MS study
por: Theiner, Sarah, et al.
Publicado: (2018)

Organometallic indolo[3,2-c]quinolines versus indolo[3,2-d]benzazepines: synthesis, structural and spectroscopic characterization, and biological efficacy
por: Filak, Lukas K., et al.
Publicado: (2010)

Optimal knockout strategies in genome-scale metabolic networks using particle swarm optimization
por: Nair, Govind, et al.
Publicado: (2017)

Iron Metallodrugs: Stability, Redox Activity and Toxicity against Artemia salina
por: Vitorino, Hector Aguilar, et al.
Publicado: (2015)

Cellular Basis of Organotin(IV) Derivatives as Anticancer Metallodrugs: A Review
por: Syed Annuar, Sharifah Nadhira, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_7dhrej1bcqi3qtacorm6bd41q6