CHIP/STUB1 Ubiquitin Ligase Functions as a Negative Regulator of ErbB2 by Promoting Its Early Post-Biosynthesis Degradation

SIMPLE SUMMARY: Overexpressed ErbB2/HER2 receptor drives up to a quarter of breast cancers. One aspect of ErbB2 biology that is poorly understood is how it reaches the cell surface following biosynthesis in the endoplasmic reticulum (ER). Here, the authors show that the CHIP (C-terminus of HSC70-Int...

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Detalles Bibliográficos
Autores principales: Luan, Haitao, Bailey, Tameka A., Clubb, Robert J., Mohapatra, Bhopal C., Bhat, Aaqib M., Chakraborty, Sukanya, Islam, Namista, Mushtaq, Insha, Storck, Matthew D., Raja, Srikumar M., Band, Vimla, Band, Hamid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391510/
https://www.ncbi.nlm.nih.gov/pubmed/34439093
http://dx.doi.org/10.3390/cancers13163936

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