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PD-L1 Overexpression, SWI/SNF Complex Deregulation, and Profound Transcriptomic Changes Characterize Cancer-Dependent Exhaustion of Persistently Activated CD4(+) T Cells

SIMPLE SUMMARY: Growing tumors induce an immune response. For proper immune response, both CD8(+) and CD4(+) effector T cells are required. Tumors avoid attacks from tumor-infiltrating lymphocytes (TILs) via induction of several inhibitory signals, such as PD-L1/2, which bind to the PD-1 receptor, c...

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Detalles Bibliográficos
Autores principales:	Jancewicz, Iga, Szarkowska, Joanna, Konopinski, Ryszard, Stachowiak, Malgorzata, Swiatek, Monika, Blachnio, Katarzyna, Kubala, Szymon, Oksinska, Paulina, Cwiek, Pawel, Rusetska, Natalia, Tupalska, Agnieszka, Zeber-Lubecka, Natalia, Grabowska, Ewa, Swiderska, Bianka, Malinowska, Agata, Mikula, Michal, Jagielska, Beata, Walewski, Jan, Siedlecki, Janusz A., Sarnowski, Tomasz J., Markowicz, Sergiusz, Sarnowska, Elzbieta A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391521/ https://www.ncbi.nlm.nih.gov/pubmed/34439305 http://dx.doi.org/10.3390/cancers13164148

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