Severity of Idiopathic Scoliosis Is Associated with Differential Methylation: An Epigenome-Wide Association Study of Monozygotic Twins with Idiopathic Scoliosis

Epigenetic mechanisms may contribute to idiopathic scoliosis (IS). We identified 8 monozygotic twin pairs with IS, 6 discordant (Cobb angle difference > 10°) and 2 concordant (Cobb angle difference ≤ 2°). Genome-wide methylation in blood was measured with the Infinium HumanMethylation EPIC Beadch...

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Autores principales: Carry, Patrick M., Terhune, Elizabeth A., Trahan, George D., Vanderlinden, Lauren A., Wethey, Cambria I., Ebrahimi, Parvaneh, McGuigan, Fiona, Åkesson, Kristina, Hadley-Miller, Nancy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391702/
https://www.ncbi.nlm.nih.gov/pubmed/34440365
http://dx.doi.org/10.3390/genes12081191

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