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Relevance of BET Family Proteins in SARS-CoV-2 Infection

The recent pandemic we are experiencing caused by the coronavirus disease 2019 (COVID-19) has put the world’s population on the rack, with more than 191 million cases and more than 4.1 million deaths confirmed to date. This disease is caused by a new type of coronavirus, the severe acute respiratory...

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Autores principales: Lara-Ureña, Nieves, García-Domínguez, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391731/
https://www.ncbi.nlm.nih.gov/pubmed/34439792
http://dx.doi.org/10.3390/biom11081126
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author Lara-Ureña, Nieves
García-Domínguez, Mario
author_facet Lara-Ureña, Nieves
García-Domínguez, Mario
author_sort Lara-Ureña, Nieves
collection PubMed
description The recent pandemic we are experiencing caused by the coronavirus disease 2019 (COVID-19) has put the world’s population on the rack, with more than 191 million cases and more than 4.1 million deaths confirmed to date. This disease is caused by a new type of coronavirus, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A massive proteomic analysis has revealed that one of the structural proteins of the virus, the E protein, interacts with BRD2 and BRD4 proteins of the Bromodomain and Extra Terminal domain (BET) family of proteins. BETs are essential to cell cycle progression, inflammation and immune response and have also been strongly associated with infection by different types of viruses. The fundamental role BET proteins play in transcription makes them appropriate targets for the propagation strategies of some viruses. Recognition of histone acetylation by BET bromodomains is essential for transcription control. The development of drugs mimicking acetyl groups, and thereby able to displace BET proteins from chromatin, has boosted interest on BETs as attractive targets for therapeutic intervention. The success of these drugs against a variety of diseases in cellular and animal models has been recently enlarged with promising results from SARS-CoV-2 infection studies.
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spelling pubmed-83917312021-08-28 Relevance of BET Family Proteins in SARS-CoV-2 Infection Lara-Ureña, Nieves García-Domínguez, Mario Biomolecules Review The recent pandemic we are experiencing caused by the coronavirus disease 2019 (COVID-19) has put the world’s population on the rack, with more than 191 million cases and more than 4.1 million deaths confirmed to date. This disease is caused by a new type of coronavirus, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A massive proteomic analysis has revealed that one of the structural proteins of the virus, the E protein, interacts with BRD2 and BRD4 proteins of the Bromodomain and Extra Terminal domain (BET) family of proteins. BETs are essential to cell cycle progression, inflammation and immune response and have also been strongly associated with infection by different types of viruses. The fundamental role BET proteins play in transcription makes them appropriate targets for the propagation strategies of some viruses. Recognition of histone acetylation by BET bromodomains is essential for transcription control. The development of drugs mimicking acetyl groups, and thereby able to displace BET proteins from chromatin, has boosted interest on BETs as attractive targets for therapeutic intervention. The success of these drugs against a variety of diseases in cellular and animal models has been recently enlarged with promising results from SARS-CoV-2 infection studies. MDPI 2021-07-30 /pmc/articles/PMC8391731/ /pubmed/34439792 http://dx.doi.org/10.3390/biom11081126 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lara-Ureña, Nieves
García-Domínguez, Mario
Relevance of BET Family Proteins in SARS-CoV-2 Infection
title Relevance of BET Family Proteins in SARS-CoV-2 Infection
title_full Relevance of BET Family Proteins in SARS-CoV-2 Infection
title_fullStr Relevance of BET Family Proteins in SARS-CoV-2 Infection
title_full_unstemmed Relevance of BET Family Proteins in SARS-CoV-2 Infection
title_short Relevance of BET Family Proteins in SARS-CoV-2 Infection
title_sort relevance of bet family proteins in sars-cov-2 infection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391731/
https://www.ncbi.nlm.nih.gov/pubmed/34439792
http://dx.doi.org/10.3390/biom11081126
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