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Neighborhood Exposures and Blood Pressure Outcomes: A Cross-Sectional Environmental Study among 19–53 Years-Old Parsis in Mumbai

The correlation between high blood pressure (BP) and urban neighborhood-level environmental determinants is understudied in low-income and middle-income countries (LMICs). We hypothesized that neighborhoods constitute exposures that affect resident-behaviors, metabolism and increased susceptibility...

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Autores principales: Sehgal, Hitakshi, Toscano, William A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391786/
https://www.ncbi.nlm.nih.gov/pubmed/34444346
http://dx.doi.org/10.3390/ijerph18168594
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author Sehgal, Hitakshi
Toscano, William A.
author_facet Sehgal, Hitakshi
Toscano, William A.
author_sort Sehgal, Hitakshi
collection PubMed
description The correlation between high blood pressure (BP) and urban neighborhood-level environmental determinants is understudied in low-income and middle-income countries (LMICs). We hypothesized that neighborhoods constitute exposures that affect resident-behaviors, metabolism and increased susceptibility to high BP. We studied urban clusters of Mumbai-Parsis (Zoroastrians), a founder population group, to minimize genetic variation and maximize exposure assessment. Participants from four neighborhoods were 19–53 years old and comprised 756 females and 774 males. We recorded healthy BPs (≤120/80 mmHg) in 59%, pre-hypertensive (≥121–139/81–89 mmHg) in 21% and high BP (≥140/90 mmHg) in 21% of the participants. A family history of hypertension had no correlation with high BP. We used the Neighborhood Accessibility Framework to compile a questionnaire in order to collect data on participants’ perception of space, third places, streetscape and experience, land use, connectivity, surveillance, pedestrian safety and public transport. Our results suggested that participants in neighborhoods with poorer BP outcomes reported lower accessibility scores for space, streetscape and experience, third places and connectivity. Our study evaluates how neighborhood-level determinants affect BP outcomes in order to contribute to the body of knowledge on primary preventive measures for high BP in urban LMIC populations. We concluded that neighborhood exposures affect resident-behaviors, which cause metabolic changes and increase susceptibility to high BP.
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spelling pubmed-83917862021-08-28 Neighborhood Exposures and Blood Pressure Outcomes: A Cross-Sectional Environmental Study among 19–53 Years-Old Parsis in Mumbai Sehgal, Hitakshi Toscano, William A. Int J Environ Res Public Health Article The correlation between high blood pressure (BP) and urban neighborhood-level environmental determinants is understudied in low-income and middle-income countries (LMICs). We hypothesized that neighborhoods constitute exposures that affect resident-behaviors, metabolism and increased susceptibility to high BP. We studied urban clusters of Mumbai-Parsis (Zoroastrians), a founder population group, to minimize genetic variation and maximize exposure assessment. Participants from four neighborhoods were 19–53 years old and comprised 756 females and 774 males. We recorded healthy BPs (≤120/80 mmHg) in 59%, pre-hypertensive (≥121–139/81–89 mmHg) in 21% and high BP (≥140/90 mmHg) in 21% of the participants. A family history of hypertension had no correlation with high BP. We used the Neighborhood Accessibility Framework to compile a questionnaire in order to collect data on participants’ perception of space, third places, streetscape and experience, land use, connectivity, surveillance, pedestrian safety and public transport. Our results suggested that participants in neighborhoods with poorer BP outcomes reported lower accessibility scores for space, streetscape and experience, third places and connectivity. Our study evaluates how neighborhood-level determinants affect BP outcomes in order to contribute to the body of knowledge on primary preventive measures for high BP in urban LMIC populations. We concluded that neighborhood exposures affect resident-behaviors, which cause metabolic changes and increase susceptibility to high BP. MDPI 2021-08-14 /pmc/articles/PMC8391786/ /pubmed/34444346 http://dx.doi.org/10.3390/ijerph18168594 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sehgal, Hitakshi
Toscano, William A.
Neighborhood Exposures and Blood Pressure Outcomes: A Cross-Sectional Environmental Study among 19–53 Years-Old Parsis in Mumbai
title Neighborhood Exposures and Blood Pressure Outcomes: A Cross-Sectional Environmental Study among 19–53 Years-Old Parsis in Mumbai
title_full Neighborhood Exposures and Blood Pressure Outcomes: A Cross-Sectional Environmental Study among 19–53 Years-Old Parsis in Mumbai
title_fullStr Neighborhood Exposures and Blood Pressure Outcomes: A Cross-Sectional Environmental Study among 19–53 Years-Old Parsis in Mumbai
title_full_unstemmed Neighborhood Exposures and Blood Pressure Outcomes: A Cross-Sectional Environmental Study among 19–53 Years-Old Parsis in Mumbai
title_short Neighborhood Exposures and Blood Pressure Outcomes: A Cross-Sectional Environmental Study among 19–53 Years-Old Parsis in Mumbai
title_sort neighborhood exposures and blood pressure outcomes: a cross-sectional environmental study among 19–53 years-old parsis in mumbai
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391786/
https://www.ncbi.nlm.nih.gov/pubmed/34444346
http://dx.doi.org/10.3390/ijerph18168594
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