Cargando…

ELOVL5-Mediated Long Chain Fatty Acid Elongation Contributes to Enzalutamide Resistance of Prostate Cancer

SIMPLE SUMMARY: The resistance mechanism of hormonal therapy has been a long-sought-after but not-yet-understood research topic in the prostate cancer (PCa) field. Here, we provide new mechanistic insights into how long-chain fatty acid contributes to enzalutamide resistance of prostate cancer. We d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Huan, Li, Sangsang, Sun, Yi, Xu, Lingfan, Hong, Xin, Wang, Zhong, Hu, Hailiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391805/ https://www.ncbi.nlm.nih.gov/pubmed/34439125 http://dx.doi.org/10.3390/cancers13163957

Ejemplares similares

Elongation of very Long-Chain (>C(24)) Fatty Acids in Clarias gariepinus: Cloning, Functional Characterization and Tissue Expression of elovl4 Elongases
por: Oboh, Angela, et al.
Publicado: (2017)

Remodeling of Retinal Fatty Acids in an Animal Model of Diabetes: A Decrease in Long-Chain Polyunsaturated Fatty Acids Is Associated With a Decrease in Fatty Acid Elongases Elovl2 and Elovl4
por: Tikhonenko, Maria, et al.
Publicado: (2010)

Cloning and expression characterization of elongation of very long-chain fatty acids protein 6 (elovl6) with dietary fatty acids, ambient salinity and starvation stress in Scylla paramamosain
por: Lin, Zhideng, et al.
Publicado: (2023)

Polyunsaturated fatty acid elongation and desaturation in activated human T-cells: ELOVL5 is the key elongase
por: Robichaud, Philippe-Pierre, et al.
Publicado: (2018)

The role of ELOVL1 in very long-chain fatty acid homeostasis and X-linked adrenoleukodystrophy
por: Ofman, Rob, et al.
Publicado: (2010)

ELOVL5‐mediated fatty acid elongation promotes cellular proliferation and invasion in renal cell carcinoma
por: Nitta, Satoshi, et al.
Publicado: (2022)

ELOVL4: Very long-chain fatty acids serve an eclectic role in mammalian health and function
por: Hopiavuori, Blake R., et al.
Publicado: (2018)

Novel Cellular Functions of Very Long Chain-Fatty Acids: Insight From ELOVL4 Mutations
por: Deák, Ferenc, et al.
Publicado: (2019)

Glioblastoma Multiforme Tumors in Women Have a Lower Expression of Fatty Acid Elongases ELOVL2, ELOVL5, ELOVL6, and ELOVL7 than in Men
por: Korbecki, Jan, et al.
Publicado: (2022)

Two Modes of Regulation of the Fatty Acid Elongase ELOVL6 by the 3-Ketoacyl-CoA Reductase KAR in the Fatty Acid Elongation Cycle
por: Naganuma, Tatsuro, et al.
Publicado: (2014)

Very long chain fatty acid-containing lipids: a decade of novel insights from the study of ELOVL4
por: Yeboah, Gyening Kofi, et al.
Publicado: (2021)

ELOVL4 Mutations That Cause Spinocerebellar Ataxia-34 Differentially Alter Very Long Chain Fatty Acid Biosynthesis
por: Gyening, Yeboah Kofi, et al.
Publicado: (2022)

Fatty Acid Elongase 7 (ELOVL7) Plays a Role in the Synthesis of Long-Chain Unsaturated Fatty Acids in Goat Mammary Epithelial Cells
por: Shi, Hengbo, et al.
Publicado: (2019)

Essential role of Elovl4 in very long chain fatty acid synthesis, skin permeability barrier function, and neonatal survival
por: Cameron, D. Joshua, et al.
Publicado: (2007)

Estrogen Promotes Hepatic Synthesis of Long-Chain Polyunsaturated Fatty Acids by Regulating ELOVL5 at Post-Transcriptional Level in Laying Hens
por: Zhang, Meng, et al.
Publicado: (2017)

Involvement of Long Chain Fatty Acid Elongation in the Trafficking of Secretory Vesicles in Yeast
por: David, Doris, et al.
Publicado: (1998)

The lipid elongation enzyme ELOVL2 is a molecular regulator of aging in the retina
por: Chen, Daniel, et al.
Publicado: (2020)

Homozygous Expression of Mutant ELOVL4 Leads to Seizures and Death in a Novel Animal Model of Very Long-Chain Fatty Acid Deficiency
por: Hopiavuori, Blake R., et al.
Publicado: (2017)

Reduced chain length in myelin sphingolipids and poorer motor coordination in mice deficient in the fatty acid elongase Elovl1
por: Isokawa, Masashi, et al.
Publicado: (2019)

Elongation of Long‐Chain Fatty Acid Family Member 6 (Elovl6)‐Driven Fatty Acid Metabolism Regulates Vascular Smooth Muscle Cell Phenotype Through AMP‐Activated Protein Kinase/Krüppel‐Like Factor 4 (AMPK/KLF4) Signaling
por: Sunaga, Hiroaki, et al.
Publicado: (2016)

Depletion of ceramides with very long chain fatty acids causes defective skin permeability barrier function, and neonatal lethality in ELOVL4 deficient mice
por: Li, Wenmei, et al.
Publicado: (2007)

Bezafibrate lowers very long-chain fatty acids in X-linked adrenoleukodystrophy fibroblasts by inhibiting fatty acid elongation
por: Engelen, Marc, et al.
Publicado: (2012)

Association Analysis between Genetic Variants of elovl5a and elovl5b and Poly-Unsaturated Fatty Acids in Common Carp (Cyprinus carpio)
por: Zhang, Yan, et al.
Publicado: (2022)

Brassinosteroids regulate cotton fiber elongation by modulating very-long-chain fatty acid biosynthesis
por: Yang, Zuoren, et al.
Publicado: (2023)

rs953413 Regulates Polyunsaturated Fatty Acid Metabolism by Modulating ELOVL2 Expression
por: Pan, Gang, et al.
Publicado: (2020)

CRISPR/Cas9-mediated ablation of elovl2 in Atlantic salmon (Salmo salar L.) inhibits elongation of polyunsaturated fatty acids and induces Srebp-1 and target genes
por: Datsomor, Alex K., et al.
Publicado: (2019)

Endoplasmic reticulum microenvironment and conserved histidines govern ELOVL4 fatty acid elongase activity
por: Logan, Sreemathi, et al.
Publicado: (2014)

Evolution and Functional Characteristics of the Novel elovl8 That Play Pivotal Roles in Fatty Acid Biosynthesis
por: Sun, Shouxiang, et al.
Publicado: (2021)

The fatty acid elongase Elovl6 is crucial for hematopoietic stem cell engraftment and leukemia propagation
por: Kiyoki, Yusuke, et al.
Publicado: (2023)

Differences in elongation of very long chain fatty acids and fatty acid metabolism between triple-negative and hormone receptor-positive breast cancer
por: Yamashita, Yuji, et al.
Publicado: (2017)

GhBZR3 suppresses cotton fiber elongation by inhibiting very‐long‐chain fatty acid biosynthesis
por: Shi, Zemin, et al.
Publicado: (2022)

Novel Approaches for Elongation of Fish Oils into Very-Long-Chain Polyunsaturated Fatty Acids and Their Enzymatic Interesterification into Glycerolipids
por: Honzíková, Tereza, et al.
Publicado: (2023)

Polymorphism in the ELOVL6 Gene Is Associated with a Major QTL Effect on Fatty Acid Composition in Pigs
por: Corominas, Jordi, et al.
Publicado: (2013)

Association of maternal weight with FADS and ELOVL genetic variants and fatty acid levels- The PREOBE follow-up
por: de la Garza Puentes, Andrea, et al.
Publicado: (2017)

Molecular determinants for enzalutamide-induced transcription in prostate cancer
por: Yuan, Fuwen, et al.
Publicado: (2019)

Seawater Culture Increases Omega-3 Long-Chain Polyunsaturated Fatty Acids (N-3 LC-PUFA) Levels in Japanese Sea Bass (Lateolabrax japonicus), Probably by Upregulating Elovl5
por: Dong, Xiaojing, et al.
Publicado: (2020)

Deletion of ELOVL6 blocks the synthesis of oleic acid but does not prevent the development of fatty liver or insulin resistance
por: Moon, Young-Ah, et al.
Publicado: (2014)

Epigenetic regulation of the ELOVL6 gene is associated with a major QTL effect on fatty acid composition in pigs
por: Corominas, Jordi, et al.
Publicado: (2015)

Elovl2-Ablation Leads to Mitochondrial Membrane Fatty Acid Remodeling and Reduced Efficiency in Mouse Liver Mitochondria
por: Gómez Rodríguez, Alexia, et al.
Publicado: (2022)

Effects of the administration of Elovl5-dependent fatty acids on a spino-cerebellar ataxia 38 mouse model
por: Balbo, Ilaria, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_n429a572lupd3iu7qj3h98me9p