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Alavi–Carlsen Calcification Score (ACCS): A Simple Measure of Global Cardiac Atherosclerosis Burden
Multislice cardiac CT characterizes late stage macrocalcification in epicardial arteries as opposed to PET/CT, which mirrors early phase arterial wall changes in epicardial and transmural coronary arteries. With regard to tracer, there has been a shift from using mainly (18)F-fluorodeoxyglucose (FDG...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391812/ https://www.ncbi.nlm.nih.gov/pubmed/34441355 http://dx.doi.org/10.3390/diagnostics11081421 |
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author | Saboury, Babak Edenbrandt, Lars Piri, Reza Gerke, Oke Werner, Tom Arbab-Zadeh, Armin Alavi, Abass Høilund-Carlsen, Poul Flemming |
author_facet | Saboury, Babak Edenbrandt, Lars Piri, Reza Gerke, Oke Werner, Tom Arbab-Zadeh, Armin Alavi, Abass Høilund-Carlsen, Poul Flemming |
author_sort | Saboury, Babak |
collection | PubMed |
description | Multislice cardiac CT characterizes late stage macrocalcification in epicardial arteries as opposed to PET/CT, which mirrors early phase arterial wall changes in epicardial and transmural coronary arteries. With regard to tracer, there has been a shift from using mainly (18)F-fluorodeoxyglucose (FDG), indicating inflammation, to applying predominantly (18)F-sodium fluoride (NaF) due to its high affinity for arterial wall microcalcification and more consistent association with cardiovascular risk factors. To make NaF-PET/CT an indispensable adjunct to clinical assessment of cardiac atherosclerosis, the Alavi–Carlsen Calcification Score (ACCS) has been proposed. It constitutes a global assessment of cardiac atherosclerosis burden in the individual patient, supported by an artificial intelligence (AI)-based approach for fast observer-independent segmentation. Common measures for characterizing epicardial coronary atherosclerosis by NaF-PET/CT as the maximum standardized uptake value (SUV) or target-to-background ratio are more versatile, error prone, and less reproducible than the ACCS, which equals the average cardiac SUV. The AI-based approach ensures a quick and easy delineation of the entire heart in 3D to obtain the ACCS expressing ongoing global cardiac atherosclerosis, even before it gives rise to CT-detectable coronary calcification. The quantification of global cardiac atherosclerotic burden by the ACCS is suited for management triage and monitoring of disease progression with and without intervention. |
format | Online Article Text |
id | pubmed-8391812 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83918122021-08-28 Alavi–Carlsen Calcification Score (ACCS): A Simple Measure of Global Cardiac Atherosclerosis Burden Saboury, Babak Edenbrandt, Lars Piri, Reza Gerke, Oke Werner, Tom Arbab-Zadeh, Armin Alavi, Abass Høilund-Carlsen, Poul Flemming Diagnostics (Basel) Commentary Multislice cardiac CT characterizes late stage macrocalcification in epicardial arteries as opposed to PET/CT, which mirrors early phase arterial wall changes in epicardial and transmural coronary arteries. With regard to tracer, there has been a shift from using mainly (18)F-fluorodeoxyglucose (FDG), indicating inflammation, to applying predominantly (18)F-sodium fluoride (NaF) due to its high affinity for arterial wall microcalcification and more consistent association with cardiovascular risk factors. To make NaF-PET/CT an indispensable adjunct to clinical assessment of cardiac atherosclerosis, the Alavi–Carlsen Calcification Score (ACCS) has been proposed. It constitutes a global assessment of cardiac atherosclerosis burden in the individual patient, supported by an artificial intelligence (AI)-based approach for fast observer-independent segmentation. Common measures for characterizing epicardial coronary atherosclerosis by NaF-PET/CT as the maximum standardized uptake value (SUV) or target-to-background ratio are more versatile, error prone, and less reproducible than the ACCS, which equals the average cardiac SUV. The AI-based approach ensures a quick and easy delineation of the entire heart in 3D to obtain the ACCS expressing ongoing global cardiac atherosclerosis, even before it gives rise to CT-detectable coronary calcification. The quantification of global cardiac atherosclerotic burden by the ACCS is suited for management triage and monitoring of disease progression with and without intervention. MDPI 2021-08-05 /pmc/articles/PMC8391812/ /pubmed/34441355 http://dx.doi.org/10.3390/diagnostics11081421 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Commentary Saboury, Babak Edenbrandt, Lars Piri, Reza Gerke, Oke Werner, Tom Arbab-Zadeh, Armin Alavi, Abass Høilund-Carlsen, Poul Flemming Alavi–Carlsen Calcification Score (ACCS): A Simple Measure of Global Cardiac Atherosclerosis Burden |
title | Alavi–Carlsen Calcification Score (ACCS): A Simple Measure of Global Cardiac Atherosclerosis Burden |
title_full | Alavi–Carlsen Calcification Score (ACCS): A Simple Measure of Global Cardiac Atherosclerosis Burden |
title_fullStr | Alavi–Carlsen Calcification Score (ACCS): A Simple Measure of Global Cardiac Atherosclerosis Burden |
title_full_unstemmed | Alavi–Carlsen Calcification Score (ACCS): A Simple Measure of Global Cardiac Atherosclerosis Burden |
title_short | Alavi–Carlsen Calcification Score (ACCS): A Simple Measure of Global Cardiac Atherosclerosis Burden |
title_sort | alavi–carlsen calcification score (accs): a simple measure of global cardiac atherosclerosis burden |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391812/ https://www.ncbi.nlm.nih.gov/pubmed/34441355 http://dx.doi.org/10.3390/diagnostics11081421 |
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