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Alavi–Carlsen Calcification Score (ACCS): A Simple Measure of Global Cardiac Atherosclerosis Burden

Multislice cardiac CT characterizes late stage macrocalcification in epicardial arteries as opposed to PET/CT, which mirrors early phase arterial wall changes in epicardial and transmural coronary arteries. With regard to tracer, there has been a shift from using mainly (18)F-fluorodeoxyglucose (FDG...

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Autores principales: Saboury, Babak, Edenbrandt, Lars, Piri, Reza, Gerke, Oke, Werner, Tom, Arbab-Zadeh, Armin, Alavi, Abass, Høilund-Carlsen, Poul Flemming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391812/
https://www.ncbi.nlm.nih.gov/pubmed/34441355
http://dx.doi.org/10.3390/diagnostics11081421
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author Saboury, Babak
Edenbrandt, Lars
Piri, Reza
Gerke, Oke
Werner, Tom
Arbab-Zadeh, Armin
Alavi, Abass
Høilund-Carlsen, Poul Flemming
author_facet Saboury, Babak
Edenbrandt, Lars
Piri, Reza
Gerke, Oke
Werner, Tom
Arbab-Zadeh, Armin
Alavi, Abass
Høilund-Carlsen, Poul Flemming
author_sort Saboury, Babak
collection PubMed
description Multislice cardiac CT characterizes late stage macrocalcification in epicardial arteries as opposed to PET/CT, which mirrors early phase arterial wall changes in epicardial and transmural coronary arteries. With regard to tracer, there has been a shift from using mainly (18)F-fluorodeoxyglucose (FDG), indicating inflammation, to applying predominantly (18)F-sodium fluoride (NaF) due to its high affinity for arterial wall microcalcification and more consistent association with cardiovascular risk factors. To make NaF-PET/CT an indispensable adjunct to clinical assessment of cardiac atherosclerosis, the Alavi–Carlsen Calcification Score (ACCS) has been proposed. It constitutes a global assessment of cardiac atherosclerosis burden in the individual patient, supported by an artificial intelligence (AI)-based approach for fast observer-independent segmentation. Common measures for characterizing epicardial coronary atherosclerosis by NaF-PET/CT as the maximum standardized uptake value (SUV) or target-to-background ratio are more versatile, error prone, and less reproducible than the ACCS, which equals the average cardiac SUV. The AI-based approach ensures a quick and easy delineation of the entire heart in 3D to obtain the ACCS expressing ongoing global cardiac atherosclerosis, even before it gives rise to CT-detectable coronary calcification. The quantification of global cardiac atherosclerotic burden by the ACCS is suited for management triage and monitoring of disease progression with and without intervention.
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spelling pubmed-83918122021-08-28 Alavi–Carlsen Calcification Score (ACCS): A Simple Measure of Global Cardiac Atherosclerosis Burden Saboury, Babak Edenbrandt, Lars Piri, Reza Gerke, Oke Werner, Tom Arbab-Zadeh, Armin Alavi, Abass Høilund-Carlsen, Poul Flemming Diagnostics (Basel) Commentary Multislice cardiac CT characterizes late stage macrocalcification in epicardial arteries as opposed to PET/CT, which mirrors early phase arterial wall changes in epicardial and transmural coronary arteries. With regard to tracer, there has been a shift from using mainly (18)F-fluorodeoxyglucose (FDG), indicating inflammation, to applying predominantly (18)F-sodium fluoride (NaF) due to its high affinity for arterial wall microcalcification and more consistent association with cardiovascular risk factors. To make NaF-PET/CT an indispensable adjunct to clinical assessment of cardiac atherosclerosis, the Alavi–Carlsen Calcification Score (ACCS) has been proposed. It constitutes a global assessment of cardiac atherosclerosis burden in the individual patient, supported by an artificial intelligence (AI)-based approach for fast observer-independent segmentation. Common measures for characterizing epicardial coronary atherosclerosis by NaF-PET/CT as the maximum standardized uptake value (SUV) or target-to-background ratio are more versatile, error prone, and less reproducible than the ACCS, which equals the average cardiac SUV. The AI-based approach ensures a quick and easy delineation of the entire heart in 3D to obtain the ACCS expressing ongoing global cardiac atherosclerosis, even before it gives rise to CT-detectable coronary calcification. The quantification of global cardiac atherosclerotic burden by the ACCS is suited for management triage and monitoring of disease progression with and without intervention. MDPI 2021-08-05 /pmc/articles/PMC8391812/ /pubmed/34441355 http://dx.doi.org/10.3390/diagnostics11081421 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Commentary
Saboury, Babak
Edenbrandt, Lars
Piri, Reza
Gerke, Oke
Werner, Tom
Arbab-Zadeh, Armin
Alavi, Abass
Høilund-Carlsen, Poul Flemming
Alavi–Carlsen Calcification Score (ACCS): A Simple Measure of Global Cardiac Atherosclerosis Burden
title Alavi–Carlsen Calcification Score (ACCS): A Simple Measure of Global Cardiac Atherosclerosis Burden
title_full Alavi–Carlsen Calcification Score (ACCS): A Simple Measure of Global Cardiac Atherosclerosis Burden
title_fullStr Alavi–Carlsen Calcification Score (ACCS): A Simple Measure of Global Cardiac Atherosclerosis Burden
title_full_unstemmed Alavi–Carlsen Calcification Score (ACCS): A Simple Measure of Global Cardiac Atherosclerosis Burden
title_short Alavi–Carlsen Calcification Score (ACCS): A Simple Measure of Global Cardiac Atherosclerosis Burden
title_sort alavi–carlsen calcification score (accs): a simple measure of global cardiac atherosclerosis burden
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391812/
https://www.ncbi.nlm.nih.gov/pubmed/34441355
http://dx.doi.org/10.3390/diagnostics11081421
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