Inflammation and Aging of Hematopoietic Stem Cells in Their Niche

Hematopoietic stem cells (HSCs) sustain the lifelong production of all blood cell lineages. The functioning of aged HSCs is impaired, including a declined repopulation capacity and myeloid and platelet-restricted differentiation. Both cell-intrinsic and microenvironmental extrinsic factors contribut...

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Detalles Bibliográficos
Autores principales: Yang, Daozheng, de Haan, Gerald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391820/
https://www.ncbi.nlm.nih.gov/pubmed/34440618
http://dx.doi.org/10.3390/cells10081849
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author Yang, Daozheng
de Haan, Gerald
author_facet Yang, Daozheng
de Haan, Gerald
author_sort Yang, Daozheng
collection PubMed
description Hematopoietic stem cells (HSCs) sustain the lifelong production of all blood cell lineages. The functioning of aged HSCs is impaired, including a declined repopulation capacity and myeloid and platelet-restricted differentiation. Both cell-intrinsic and microenvironmental extrinsic factors contribute to HSC aging. Recent studies highlight the emerging role of inflammation in contributing to HSC aging. In this review, we summarize the recent finding of age-associated changes of HSCs and the bone marrow niche in which they lodge, and discuss how inflammation may drive HSC aging.
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spelling pubmed-83918202021-08-28 Inflammation and Aging of Hematopoietic Stem Cells in Their Niche Yang, Daozheng de Haan, Gerald Cells Review Hematopoietic stem cells (HSCs) sustain the lifelong production of all blood cell lineages. The functioning of aged HSCs is impaired, including a declined repopulation capacity and myeloid and platelet-restricted differentiation. Both cell-intrinsic and microenvironmental extrinsic factors contribute to HSC aging. Recent studies highlight the emerging role of inflammation in contributing to HSC aging. In this review, we summarize the recent finding of age-associated changes of HSCs and the bone marrow niche in which they lodge, and discuss how inflammation may drive HSC aging. MDPI 2021-07-21 /pmc/articles/PMC8391820/ /pubmed/34440618 http://dx.doi.org/10.3390/cells10081849 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yang, Daozheng
de Haan, Gerald
Inflammation and Aging of Hematopoietic Stem Cells in Their Niche
title Inflammation and Aging of Hematopoietic Stem Cells in Their Niche
title_full Inflammation and Aging of Hematopoietic Stem Cells in Their Niche
title_fullStr Inflammation and Aging of Hematopoietic Stem Cells in Their Niche
title_full_unstemmed Inflammation and Aging of Hematopoietic Stem Cells in Their Niche
title_short Inflammation and Aging of Hematopoietic Stem Cells in Their Niche
title_sort inflammation and aging of hematopoietic stem cells in their niche
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391820/
https://www.ncbi.nlm.nih.gov/pubmed/34440618
http://dx.doi.org/10.3390/cells10081849
work_keys_str_mv AT yangdaozheng inflammationandagingofhematopoieticstemcellsintheirniche
AT dehaangerald inflammationandagingofhematopoieticstemcellsintheirniche

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