Cargando…

Novel effects of acute COVID‐19 on cardiac mechanical function: Two case studies

The spread of the novel coronavirus 2019 (COVID‐19) has caused a global pandemic. The disease has spread rapidly, and research shows that COVID‐19 can induce long‐lasting cardiac damage. COVID‐19 can result in elevated cardiac biomarkers indicative of acute cardiac injury, and research utilizing ech...

Descripción completa

Detalles Bibliográficos
Autores principales: Singh, Jyotpal, Bhagaloo, Lanishen, Sy, Eric, Lavoie, Andrea J., Dehghani, Payam, Neary, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391984/
https://www.ncbi.nlm.nih.gov/pubmed/34448551
http://dx.doi.org/10.14814/phy2.14998
_version_ 1783743400115175424
author Singh, Jyotpal
Bhagaloo, Lanishen
Sy, Eric
Lavoie, Andrea J.
Dehghani, Payam
Neary, Patrick
author_facet Singh, Jyotpal
Bhagaloo, Lanishen
Sy, Eric
Lavoie, Andrea J.
Dehghani, Payam
Neary, Patrick
author_sort Singh, Jyotpal
collection PubMed
description The spread of the novel coronavirus 2019 (COVID‐19) has caused a global pandemic. The disease has spread rapidly, and research shows that COVID‐19 can induce long‐lasting cardiac damage. COVID‐19 can result in elevated cardiac biomarkers indicative of acute cardiac injury, and research utilizing echocardiography has shown that there is mechanical dysfunction in these patients as well, especially when observing the isovolumic, systolic, and diastolic portions of the cardiac cycle. The purpose of this study was to present two case studies on COVID‐19 positive patients who had their cardiac mechanical function assessed every day during the acute period to show that cardiac function in these patients was altered, and the damage occurring can change from day‐to‐day. Participant 1 showed compromised cardiac function in the systolic time, diastolic time, isovolumic time, and the calculated heart performance index (HPI), and these impairments were sustained even 23 days post‐symptom onset. Furthermore, Participant 1 showed prolonged systolic periods that lasted longer than the diastolic periods, indicative of elevated pulmonary artery pressure. Participant 2 showed decreases in systole and consequently, increases in HPI during the 3 days post‐symptom onset, and these changes returned to normal after day 4. These results showed that daily observation of cardiac function can provide detailed information about the overall mechanism by which cardiac dysfunction is occurring and that COVID‐19 can induce cardiac damage in unique patterns and thus can be studied on a case‐by‐case basis, day‐to‐day during infection. This could allow us to move toward more personalized cardiovascular medical treatment.
format Online
Article
Text
id pubmed-8391984
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-83919842021-09-02 Novel effects of acute COVID‐19 on cardiac mechanical function: Two case studies Singh, Jyotpal Bhagaloo, Lanishen Sy, Eric Lavoie, Andrea J. Dehghani, Payam Neary, Patrick Physiol Rep Case Report The spread of the novel coronavirus 2019 (COVID‐19) has caused a global pandemic. The disease has spread rapidly, and research shows that COVID‐19 can induce long‐lasting cardiac damage. COVID‐19 can result in elevated cardiac biomarkers indicative of acute cardiac injury, and research utilizing echocardiography has shown that there is mechanical dysfunction in these patients as well, especially when observing the isovolumic, systolic, and diastolic portions of the cardiac cycle. The purpose of this study was to present two case studies on COVID‐19 positive patients who had their cardiac mechanical function assessed every day during the acute period to show that cardiac function in these patients was altered, and the damage occurring can change from day‐to‐day. Participant 1 showed compromised cardiac function in the systolic time, diastolic time, isovolumic time, and the calculated heart performance index (HPI), and these impairments were sustained even 23 days post‐symptom onset. Furthermore, Participant 1 showed prolonged systolic periods that lasted longer than the diastolic periods, indicative of elevated pulmonary artery pressure. Participant 2 showed decreases in systole and consequently, increases in HPI during the 3 days post‐symptom onset, and these changes returned to normal after day 4. These results showed that daily observation of cardiac function can provide detailed information about the overall mechanism by which cardiac dysfunction is occurring and that COVID‐19 can induce cardiac damage in unique patterns and thus can be studied on a case‐by‐case basis, day‐to‐day during infection. This could allow us to move toward more personalized cardiovascular medical treatment. John Wiley and Sons Inc. 2021-08-27 /pmc/articles/PMC8391984/ /pubmed/34448551 http://dx.doi.org/10.14814/phy2.14998 Text en © 2021 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Singh, Jyotpal
Bhagaloo, Lanishen
Sy, Eric
Lavoie, Andrea J.
Dehghani, Payam
Neary, Patrick
Novel effects of acute COVID‐19 on cardiac mechanical function: Two case studies
title Novel effects of acute COVID‐19 on cardiac mechanical function: Two case studies
title_full Novel effects of acute COVID‐19 on cardiac mechanical function: Two case studies
title_fullStr Novel effects of acute COVID‐19 on cardiac mechanical function: Two case studies
title_full_unstemmed Novel effects of acute COVID‐19 on cardiac mechanical function: Two case studies
title_short Novel effects of acute COVID‐19 on cardiac mechanical function: Two case studies
title_sort novel effects of acute covid‐19 on cardiac mechanical function: two case studies
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391984/
https://www.ncbi.nlm.nih.gov/pubmed/34448551
http://dx.doi.org/10.14814/phy2.14998
work_keys_str_mv AT singhjyotpal noveleffectsofacutecovid19oncardiacmechanicalfunctiontwocasestudies
AT bhagaloolanishen noveleffectsofacutecovid19oncardiacmechanicalfunctiontwocasestudies
AT syeric noveleffectsofacutecovid19oncardiacmechanicalfunctiontwocasestudies
AT lavoieandreaj noveleffectsofacutecovid19oncardiacmechanicalfunctiontwocasestudies
AT dehghanipayam noveleffectsofacutecovid19oncardiacmechanicalfunctiontwocasestudies
AT nearypatrick noveleffectsofacutecovid19oncardiacmechanicalfunctiontwocasestudies