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Novel effects of acute COVID‐19 on cardiac mechanical function: Two case studies
The spread of the novel coronavirus 2019 (COVID‐19) has caused a global pandemic. The disease has spread rapidly, and research shows that COVID‐19 can induce long‐lasting cardiac damage. COVID‐19 can result in elevated cardiac biomarkers indicative of acute cardiac injury, and research utilizing ech...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391984/ https://www.ncbi.nlm.nih.gov/pubmed/34448551 http://dx.doi.org/10.14814/phy2.14998 |
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author | Singh, Jyotpal Bhagaloo, Lanishen Sy, Eric Lavoie, Andrea J. Dehghani, Payam Neary, Patrick |
author_facet | Singh, Jyotpal Bhagaloo, Lanishen Sy, Eric Lavoie, Andrea J. Dehghani, Payam Neary, Patrick |
author_sort | Singh, Jyotpal |
collection | PubMed |
description | The spread of the novel coronavirus 2019 (COVID‐19) has caused a global pandemic. The disease has spread rapidly, and research shows that COVID‐19 can induce long‐lasting cardiac damage. COVID‐19 can result in elevated cardiac biomarkers indicative of acute cardiac injury, and research utilizing echocardiography has shown that there is mechanical dysfunction in these patients as well, especially when observing the isovolumic, systolic, and diastolic portions of the cardiac cycle. The purpose of this study was to present two case studies on COVID‐19 positive patients who had their cardiac mechanical function assessed every day during the acute period to show that cardiac function in these patients was altered, and the damage occurring can change from day‐to‐day. Participant 1 showed compromised cardiac function in the systolic time, diastolic time, isovolumic time, and the calculated heart performance index (HPI), and these impairments were sustained even 23 days post‐symptom onset. Furthermore, Participant 1 showed prolonged systolic periods that lasted longer than the diastolic periods, indicative of elevated pulmonary artery pressure. Participant 2 showed decreases in systole and consequently, increases in HPI during the 3 days post‐symptom onset, and these changes returned to normal after day 4. These results showed that daily observation of cardiac function can provide detailed information about the overall mechanism by which cardiac dysfunction is occurring and that COVID‐19 can induce cardiac damage in unique patterns and thus can be studied on a case‐by‐case basis, day‐to‐day during infection. This could allow us to move toward more personalized cardiovascular medical treatment. |
format | Online Article Text |
id | pubmed-8391984 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83919842021-09-02 Novel effects of acute COVID‐19 on cardiac mechanical function: Two case studies Singh, Jyotpal Bhagaloo, Lanishen Sy, Eric Lavoie, Andrea J. Dehghani, Payam Neary, Patrick Physiol Rep Case Report The spread of the novel coronavirus 2019 (COVID‐19) has caused a global pandemic. The disease has spread rapidly, and research shows that COVID‐19 can induce long‐lasting cardiac damage. COVID‐19 can result in elevated cardiac biomarkers indicative of acute cardiac injury, and research utilizing echocardiography has shown that there is mechanical dysfunction in these patients as well, especially when observing the isovolumic, systolic, and diastolic portions of the cardiac cycle. The purpose of this study was to present two case studies on COVID‐19 positive patients who had their cardiac mechanical function assessed every day during the acute period to show that cardiac function in these patients was altered, and the damage occurring can change from day‐to‐day. Participant 1 showed compromised cardiac function in the systolic time, diastolic time, isovolumic time, and the calculated heart performance index (HPI), and these impairments were sustained even 23 days post‐symptom onset. Furthermore, Participant 1 showed prolonged systolic periods that lasted longer than the diastolic periods, indicative of elevated pulmonary artery pressure. Participant 2 showed decreases in systole and consequently, increases in HPI during the 3 days post‐symptom onset, and these changes returned to normal after day 4. These results showed that daily observation of cardiac function can provide detailed information about the overall mechanism by which cardiac dysfunction is occurring and that COVID‐19 can induce cardiac damage in unique patterns and thus can be studied on a case‐by‐case basis, day‐to‐day during infection. This could allow us to move toward more personalized cardiovascular medical treatment. John Wiley and Sons Inc. 2021-08-27 /pmc/articles/PMC8391984/ /pubmed/34448551 http://dx.doi.org/10.14814/phy2.14998 Text en © 2021 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Singh, Jyotpal Bhagaloo, Lanishen Sy, Eric Lavoie, Andrea J. Dehghani, Payam Neary, Patrick Novel effects of acute COVID‐19 on cardiac mechanical function: Two case studies |
title | Novel effects of acute COVID‐19 on cardiac mechanical function: Two case studies |
title_full | Novel effects of acute COVID‐19 on cardiac mechanical function: Two case studies |
title_fullStr | Novel effects of acute COVID‐19 on cardiac mechanical function: Two case studies |
title_full_unstemmed | Novel effects of acute COVID‐19 on cardiac mechanical function: Two case studies |
title_short | Novel effects of acute COVID‐19 on cardiac mechanical function: Two case studies |
title_sort | novel effects of acute covid‐19 on cardiac mechanical function: two case studies |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8391984/ https://www.ncbi.nlm.nih.gov/pubmed/34448551 http://dx.doi.org/10.14814/phy2.14998 |
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