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Serum Selenium Level and 10-Year Survival after Melanoma

Melanoma is one of the most aggressive human malignancies. The determination of prognostic biomarkers is important for the early detection of recurrence and for the enrollment of the patients into different treatment regimens. Herein, we report the 10-year survival of 375 melanoma patients depending...

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Autores principales: Rogoża-Janiszewska, Emilia, Malińska, Karolina, Baszuk, Piotr, Marciniak, Wojciech, Derkacz, Róża, Lener, Marcin, Jakubowska, Anna, Cybulski, Cezary, Huzarski, Tomasz, Masojć, Bartłomiej, Gronwald, Jacek, Rudnicka, Helena, Kram, Andrzej, Kiedrowicz, Magdalena, Boer, Magdalena, Dębniak, Tadeusz, Lubiński, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392027/
https://www.ncbi.nlm.nih.gov/pubmed/34440195
http://dx.doi.org/10.3390/biomedicines9080991
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author Rogoża-Janiszewska, Emilia
Malińska, Karolina
Baszuk, Piotr
Marciniak, Wojciech
Derkacz, Róża
Lener, Marcin
Jakubowska, Anna
Cybulski, Cezary
Huzarski, Tomasz
Masojć, Bartłomiej
Gronwald, Jacek
Rudnicka, Helena
Kram, Andrzej
Kiedrowicz, Magdalena
Boer, Magdalena
Dębniak, Tadeusz
Lubiński, Jan
author_facet Rogoża-Janiszewska, Emilia
Malińska, Karolina
Baszuk, Piotr
Marciniak, Wojciech
Derkacz, Róża
Lener, Marcin
Jakubowska, Anna
Cybulski, Cezary
Huzarski, Tomasz
Masojć, Bartłomiej
Gronwald, Jacek
Rudnicka, Helena
Kram, Andrzej
Kiedrowicz, Magdalena
Boer, Magdalena
Dębniak, Tadeusz
Lubiński, Jan
author_sort Rogoża-Janiszewska, Emilia
collection PubMed
description Melanoma is one of the most aggressive human malignancies. The determination of prognostic biomarkers is important for the early detection of recurrence and for the enrollment of the patients into different treatment regimens. Herein, we report the 10-year survival of 375 melanoma patients depending on their serum selenium levels. The study group was followed up from the date of melanoma diagnosis until death or 2020. Patients were assigned to one of four categories, in accordance with the increasing selenium level (I–IV quartiles). The subgroup with low selenium levels had a significant lower survival rate in relation to patients with high selenium levels, HR = 8.42; p = 0.005 and HR = 5.83; p = 0.02, for uni- and multivariable models, respectively. In the univariable analysis, we also confirmed the association between Breslow thickness, Clark classification and age at melanoma prognosis. In conclusion, a low serum selenium level was associated with an increased mortality rate in the 10 years following melanoma diagnosis. Future studies in other geographic regions with low soil selenium levels should be conducted to confirm our findings.
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spelling pubmed-83920272021-08-28 Serum Selenium Level and 10-Year Survival after Melanoma Rogoża-Janiszewska, Emilia Malińska, Karolina Baszuk, Piotr Marciniak, Wojciech Derkacz, Róża Lener, Marcin Jakubowska, Anna Cybulski, Cezary Huzarski, Tomasz Masojć, Bartłomiej Gronwald, Jacek Rudnicka, Helena Kram, Andrzej Kiedrowicz, Magdalena Boer, Magdalena Dębniak, Tadeusz Lubiński, Jan Biomedicines Communication Melanoma is one of the most aggressive human malignancies. The determination of prognostic biomarkers is important for the early detection of recurrence and for the enrollment of the patients into different treatment regimens. Herein, we report the 10-year survival of 375 melanoma patients depending on their serum selenium levels. The study group was followed up from the date of melanoma diagnosis until death or 2020. Patients were assigned to one of four categories, in accordance with the increasing selenium level (I–IV quartiles). The subgroup with low selenium levels had a significant lower survival rate in relation to patients with high selenium levels, HR = 8.42; p = 0.005 and HR = 5.83; p = 0.02, for uni- and multivariable models, respectively. In the univariable analysis, we also confirmed the association between Breslow thickness, Clark classification and age at melanoma prognosis. In conclusion, a low serum selenium level was associated with an increased mortality rate in the 10 years following melanoma diagnosis. Future studies in other geographic regions with low soil selenium levels should be conducted to confirm our findings. MDPI 2021-08-11 /pmc/articles/PMC8392027/ /pubmed/34440195 http://dx.doi.org/10.3390/biomedicines9080991 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Rogoża-Janiszewska, Emilia
Malińska, Karolina
Baszuk, Piotr
Marciniak, Wojciech
Derkacz, Róża
Lener, Marcin
Jakubowska, Anna
Cybulski, Cezary
Huzarski, Tomasz
Masojć, Bartłomiej
Gronwald, Jacek
Rudnicka, Helena
Kram, Andrzej
Kiedrowicz, Magdalena
Boer, Magdalena
Dębniak, Tadeusz
Lubiński, Jan
Serum Selenium Level and 10-Year Survival after Melanoma
title Serum Selenium Level and 10-Year Survival after Melanoma
title_full Serum Selenium Level and 10-Year Survival after Melanoma
title_fullStr Serum Selenium Level and 10-Year Survival after Melanoma
title_full_unstemmed Serum Selenium Level and 10-Year Survival after Melanoma
title_short Serum Selenium Level and 10-Year Survival after Melanoma
title_sort serum selenium level and 10-year survival after melanoma
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392027/
https://www.ncbi.nlm.nih.gov/pubmed/34440195
http://dx.doi.org/10.3390/biomedicines9080991
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