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Intermediate Filaments from Tissue Integrity to Single Molecule Mechanics

Cytoplasmic intermediate filaments (IFs), which together with actin and microtubules form the cytoskeleton, are composed of a large and diverse family of proteins. Efforts to elucidate the molecular mechanisms responsible for IF-associated diseases increasingly point towards a major contribution of...

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Autores principales: van Bodegraven, Emma J., Etienne-Manneville, Sandrine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392029/
https://www.ncbi.nlm.nih.gov/pubmed/34440673
http://dx.doi.org/10.3390/cells10081905
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author van Bodegraven, Emma J.
Etienne-Manneville, Sandrine
author_facet van Bodegraven, Emma J.
Etienne-Manneville, Sandrine
author_sort van Bodegraven, Emma J.
collection PubMed
description Cytoplasmic intermediate filaments (IFs), which together with actin and microtubules form the cytoskeleton, are composed of a large and diverse family of proteins. Efforts to elucidate the molecular mechanisms responsible for IF-associated diseases increasingly point towards a major contribution of IFs to the cell’s ability to adapt, resist and respond to mechanical challenges. From these observations, which echo the impressive resilience of IFs in vitro, we here discuss the role of IFs as master integrators of cell and tissue mechanics. In this review, we summarize our current understanding of the contribution of IFs to cell and tissue mechanics and explain these results in light of recent in vitro studies that have investigated physical properties of single IFs and IF networks. Finally, we highlight how changes in IF gene expression, network assembly dynamics, and post-translational modifications can tune IF properties to adapt cell and tissue mechanics to changing environments.
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spelling pubmed-83920292021-08-28 Intermediate Filaments from Tissue Integrity to Single Molecule Mechanics van Bodegraven, Emma J. Etienne-Manneville, Sandrine Cells Review Cytoplasmic intermediate filaments (IFs), which together with actin and microtubules form the cytoskeleton, are composed of a large and diverse family of proteins. Efforts to elucidate the molecular mechanisms responsible for IF-associated diseases increasingly point towards a major contribution of IFs to the cell’s ability to adapt, resist and respond to mechanical challenges. From these observations, which echo the impressive resilience of IFs in vitro, we here discuss the role of IFs as master integrators of cell and tissue mechanics. In this review, we summarize our current understanding of the contribution of IFs to cell and tissue mechanics and explain these results in light of recent in vitro studies that have investigated physical properties of single IFs and IF networks. Finally, we highlight how changes in IF gene expression, network assembly dynamics, and post-translational modifications can tune IF properties to adapt cell and tissue mechanics to changing environments. MDPI 2021-07-27 /pmc/articles/PMC8392029/ /pubmed/34440673 http://dx.doi.org/10.3390/cells10081905 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
van Bodegraven, Emma J.
Etienne-Manneville, Sandrine
Intermediate Filaments from Tissue Integrity to Single Molecule Mechanics
title Intermediate Filaments from Tissue Integrity to Single Molecule Mechanics
title_full Intermediate Filaments from Tissue Integrity to Single Molecule Mechanics
title_fullStr Intermediate Filaments from Tissue Integrity to Single Molecule Mechanics
title_full_unstemmed Intermediate Filaments from Tissue Integrity to Single Molecule Mechanics
title_short Intermediate Filaments from Tissue Integrity to Single Molecule Mechanics
title_sort intermediate filaments from tissue integrity to single molecule mechanics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392029/
https://www.ncbi.nlm.nih.gov/pubmed/34440673
http://dx.doi.org/10.3390/cells10081905
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