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Phenotypic Clustering in Non-Cystic Fibrosis Bronchiectasis Patients: The Role of Eosinophils in Disease Severity

Whether high blood eosinophil counts may define a better phenotype in bronchiectasis patients, as shown in chronic obstructive pulmonary disease (COPD), remains to be investigated. Differential phenotypic characteristics according to eosinophil counts were assessed using a biostatistical approach in...

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Autores principales: Wang, Xuejie, Villa, Carmen, Dobarganes, Yadira, Olveira, Casilda, Girón, Rosa, García-Clemente, Marta, Máiz, Luis, Sibila, Oriol, Golpe, Rafael, Menéndez, Rosario, Rodríguez-López, Juan, Prados, Concepción, Martinez-García, Miguel Angel, Rodriguez, Juan Luis, de la Rosa, David, Duran, Xavier, Garcia-Ojalvo, Jordi, Barreiro, Esther
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392197/
https://www.ncbi.nlm.nih.gov/pubmed/34444179
http://dx.doi.org/10.3390/ijerph18168431
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author Wang, Xuejie
Villa, Carmen
Dobarganes, Yadira
Olveira, Casilda
Girón, Rosa
García-Clemente, Marta
Máiz, Luis
Sibila, Oriol
Golpe, Rafael
Menéndez, Rosario
Rodríguez-López, Juan
Prados, Concepción
Martinez-García, Miguel Angel
Rodriguez, Juan Luis
de la Rosa, David
Duran, Xavier
Garcia-Ojalvo, Jordi
Barreiro, Esther
author_facet Wang, Xuejie
Villa, Carmen
Dobarganes, Yadira
Olveira, Casilda
Girón, Rosa
García-Clemente, Marta
Máiz, Luis
Sibila, Oriol
Golpe, Rafael
Menéndez, Rosario
Rodríguez-López, Juan
Prados, Concepción
Martinez-García, Miguel Angel
Rodriguez, Juan Luis
de la Rosa, David
Duran, Xavier
Garcia-Ojalvo, Jordi
Barreiro, Esther
author_sort Wang, Xuejie
collection PubMed
description Whether high blood eosinophil counts may define a better phenotype in bronchiectasis patients, as shown in chronic obstructive pulmonary disease (COPD), remains to be investigated. Differential phenotypic characteristics according to eosinophil counts were assessed using a biostatistical approach in a large cohort study from the Spanish Online Bronchiectasis Registry (RIBRON). The 906 patients who met the inclusion criteria were clustered into two groups on the basis of their eosinophil levels. The potential differences according to the bronchiectasis severity index (BSI) score between two groups (Mann–Whitney U test and eosinophil count threshold: 100 cells/µL) showed the most balanced cluster sizes: above-threshold and below-threshold groups. Patients above the threshold exhibited significantly better clinical outcomes, lung function, and nutritional status, while showing lower systemic inflammation levels. The proportion of patients with mild disease was higher in the above-threshold group, while the below-threshold patients were more severe. Two distinct clinical phenotypes of stable patients with non-cystic fibrosis (CF) bronchiectasis of a wide range of disease severity were established on the basis of blood eosinophil counts using a biostatistical approach. Patients classified within the above-threshold cluster were those exhibiting a mild disease, significantly better clinical outcomes, lung function, and nutritional status while showing lower systemic inflammatory levels. These results will contribute to better characterizing bronchiectasis patients into phenotypic profiles with their clinical implications.
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spelling pubmed-83921972021-08-28 Phenotypic Clustering in Non-Cystic Fibrosis Bronchiectasis Patients: The Role of Eosinophils in Disease Severity Wang, Xuejie Villa, Carmen Dobarganes, Yadira Olveira, Casilda Girón, Rosa García-Clemente, Marta Máiz, Luis Sibila, Oriol Golpe, Rafael Menéndez, Rosario Rodríguez-López, Juan Prados, Concepción Martinez-García, Miguel Angel Rodriguez, Juan Luis de la Rosa, David Duran, Xavier Garcia-Ojalvo, Jordi Barreiro, Esther Int J Environ Res Public Health Article Whether high blood eosinophil counts may define a better phenotype in bronchiectasis patients, as shown in chronic obstructive pulmonary disease (COPD), remains to be investigated. Differential phenotypic characteristics according to eosinophil counts were assessed using a biostatistical approach in a large cohort study from the Spanish Online Bronchiectasis Registry (RIBRON). The 906 patients who met the inclusion criteria were clustered into two groups on the basis of their eosinophil levels. The potential differences according to the bronchiectasis severity index (BSI) score between two groups (Mann–Whitney U test and eosinophil count threshold: 100 cells/µL) showed the most balanced cluster sizes: above-threshold and below-threshold groups. Patients above the threshold exhibited significantly better clinical outcomes, lung function, and nutritional status, while showing lower systemic inflammation levels. The proportion of patients with mild disease was higher in the above-threshold group, while the below-threshold patients were more severe. Two distinct clinical phenotypes of stable patients with non-cystic fibrosis (CF) bronchiectasis of a wide range of disease severity were established on the basis of blood eosinophil counts using a biostatistical approach. Patients classified within the above-threshold cluster were those exhibiting a mild disease, significantly better clinical outcomes, lung function, and nutritional status while showing lower systemic inflammatory levels. These results will contribute to better characterizing bronchiectasis patients into phenotypic profiles with their clinical implications. MDPI 2021-08-10 /pmc/articles/PMC8392197/ /pubmed/34444179 http://dx.doi.org/10.3390/ijerph18168431 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wang, Xuejie
Villa, Carmen
Dobarganes, Yadira
Olveira, Casilda
Girón, Rosa
García-Clemente, Marta
Máiz, Luis
Sibila, Oriol
Golpe, Rafael
Menéndez, Rosario
Rodríguez-López, Juan
Prados, Concepción
Martinez-García, Miguel Angel
Rodriguez, Juan Luis
de la Rosa, David
Duran, Xavier
Garcia-Ojalvo, Jordi
Barreiro, Esther
Phenotypic Clustering in Non-Cystic Fibrosis Bronchiectasis Patients: The Role of Eosinophils in Disease Severity
title Phenotypic Clustering in Non-Cystic Fibrosis Bronchiectasis Patients: The Role of Eosinophils in Disease Severity
title_full Phenotypic Clustering in Non-Cystic Fibrosis Bronchiectasis Patients: The Role of Eosinophils in Disease Severity
title_fullStr Phenotypic Clustering in Non-Cystic Fibrosis Bronchiectasis Patients: The Role of Eosinophils in Disease Severity
title_full_unstemmed Phenotypic Clustering in Non-Cystic Fibrosis Bronchiectasis Patients: The Role of Eosinophils in Disease Severity
title_short Phenotypic Clustering in Non-Cystic Fibrosis Bronchiectasis Patients: The Role of Eosinophils in Disease Severity
title_sort phenotypic clustering in non-cystic fibrosis bronchiectasis patients: the role of eosinophils in disease severity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392197/
https://www.ncbi.nlm.nih.gov/pubmed/34444179
http://dx.doi.org/10.3390/ijerph18168431
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