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Obstructive Sleep Disorders in Down Syndrome’s Children with and without Lower Airway Anomalies

(1) Background: Obstructive sleep apnea (OSA) and lower airway anomalies are both highly prevalent in children with Down syndrome (DS). However, little is known on the interaction between both. We aim to investigate the co-occurrence of OSA (defined as obstructive apnea/hypopnea index (oAHI) ≥ 2/h)...

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Autores principales: De Lausnay, Mariska, Verhulst, Stijn, Van Hoorenbeeck, Kim, Boudewyns, An
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392245/
https://www.ncbi.nlm.nih.gov/pubmed/34438584
http://dx.doi.org/10.3390/children8080693
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author De Lausnay, Mariska
Verhulst, Stijn
Van Hoorenbeeck, Kim
Boudewyns, An
author_facet De Lausnay, Mariska
Verhulst, Stijn
Van Hoorenbeeck, Kim
Boudewyns, An
author_sort De Lausnay, Mariska
collection PubMed
description (1) Background: Obstructive sleep apnea (OSA) and lower airway anomalies are both highly prevalent in children with Down syndrome (DS). However, little is known on the interaction between both. We aim to investigate the co-occurrence of OSA (defined as obstructive apnea/hypopnea index (oAHI) ≥ 2/h) and lower airway anomalies in children with DS and explore their impact on OSA severity and treatment outcome. (2) Methods: Retrospective analysis of data from airway endoscopy and polysomnography (PSG) in a cohort of children with DS. (3) Results: Data on both lower airway evaluation and PSG were available for 70 patients with DS. Our study population was relatively young (mean age 3.5 years), not obese and presented with severe OSA (mean oAHI 13.1/h). Airway anomalies were found in 49/70 children (70%), most frequently laryngomalacia, tracheomalacia or a combined airway malformation. In the remaining 21 cases (30%), endoscopy was normal. A comparison between both groups showed a similar distribution of gender, age and BMI z-scores. The prevalence of OSA was not significantly higher in DS patients with airway anomalies (89.6% vs 71.4%, p = 0.078). Additionally, OSA severity or treatment choice (conservative, upper airway surgery or CPAP) were not significantly different. Follow-up data (available for 49/70 patients) showed a significant improvement of OSA in both groups. There is a not significant tendency to more patients with persistent OSA among those with lower airway anomalies (34.3% vs 7.1%, p = 0.075). (4) Conclusions: We found no significant differences in OSA severity, treatment choice or outcome between children with DS with and without lower airway anomalies. Further studies should investigate the role of DISE-directed treatment and compare the outcome of different treatment modalities in larger patient groups.
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spelling pubmed-83922452021-08-28 Obstructive Sleep Disorders in Down Syndrome’s Children with and without Lower Airway Anomalies De Lausnay, Mariska Verhulst, Stijn Van Hoorenbeeck, Kim Boudewyns, An Children (Basel) Article (1) Background: Obstructive sleep apnea (OSA) and lower airway anomalies are both highly prevalent in children with Down syndrome (DS). However, little is known on the interaction between both. We aim to investigate the co-occurrence of OSA (defined as obstructive apnea/hypopnea index (oAHI) ≥ 2/h) and lower airway anomalies in children with DS and explore their impact on OSA severity and treatment outcome. (2) Methods: Retrospective analysis of data from airway endoscopy and polysomnography (PSG) in a cohort of children with DS. (3) Results: Data on both lower airway evaluation and PSG were available for 70 patients with DS. Our study population was relatively young (mean age 3.5 years), not obese and presented with severe OSA (mean oAHI 13.1/h). Airway anomalies were found in 49/70 children (70%), most frequently laryngomalacia, tracheomalacia or a combined airway malformation. In the remaining 21 cases (30%), endoscopy was normal. A comparison between both groups showed a similar distribution of gender, age and BMI z-scores. The prevalence of OSA was not significantly higher in DS patients with airway anomalies (89.6% vs 71.4%, p = 0.078). Additionally, OSA severity or treatment choice (conservative, upper airway surgery or CPAP) were not significantly different. Follow-up data (available for 49/70 patients) showed a significant improvement of OSA in both groups. There is a not significant tendency to more patients with persistent OSA among those with lower airway anomalies (34.3% vs 7.1%, p = 0.075). (4) Conclusions: We found no significant differences in OSA severity, treatment choice or outcome between children with DS with and without lower airway anomalies. Further studies should investigate the role of DISE-directed treatment and compare the outcome of different treatment modalities in larger patient groups. MDPI 2021-08-12 /pmc/articles/PMC8392245/ /pubmed/34438584 http://dx.doi.org/10.3390/children8080693 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
De Lausnay, Mariska
Verhulst, Stijn
Van Hoorenbeeck, Kim
Boudewyns, An
Obstructive Sleep Disorders in Down Syndrome’s Children with and without Lower Airway Anomalies
title Obstructive Sleep Disorders in Down Syndrome’s Children with and without Lower Airway Anomalies
title_full Obstructive Sleep Disorders in Down Syndrome’s Children with and without Lower Airway Anomalies
title_fullStr Obstructive Sleep Disorders in Down Syndrome’s Children with and without Lower Airway Anomalies
title_full_unstemmed Obstructive Sleep Disorders in Down Syndrome’s Children with and without Lower Airway Anomalies
title_short Obstructive Sleep Disorders in Down Syndrome’s Children with and without Lower Airway Anomalies
title_sort obstructive sleep disorders in down syndrome’s children with and without lower airway anomalies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392245/
https://www.ncbi.nlm.nih.gov/pubmed/34438584
http://dx.doi.org/10.3390/children8080693
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