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Measuring NQO1 Bioactivation Using [(2)H(7)]Glucose
SIMPLE SUMMARY: Cancer is often characterized by profound changes in metabolism, some of which are appropriate targets for therapeutic intervention. Many cancers overexpress the two-electron reductase NQO1, which can bioactivate the drug β-lapachone, inducing a futile redox cycle that liberates larg...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392257/ https://www.ncbi.nlm.nih.gov/pubmed/34439319 http://dx.doi.org/10.3390/cancers13164165 |