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Optical Imaging of Beta-Amyloid Plaques in Alzheimer’s Disease
Alzheimer’s disease (AD) is a multifactorial, irreversible, and incurable neurodegenerative disease. The main pathological feature of AD is the deposition of misfolded β-amyloid protein (Aβ) plaques in the brain. The abnormal accumulation of Aβ plaques leads to the loss of some neuron functions, fur...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392287/ https://www.ncbi.nlm.nih.gov/pubmed/34436057 http://dx.doi.org/10.3390/bios11080255 |
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author | Luo, Ziyi Xu, Hao Liu, Liwei Ohulchanskyy, Tymish Y. Qu, Junle |
author_facet | Luo, Ziyi Xu, Hao Liu, Liwei Ohulchanskyy, Tymish Y. Qu, Junle |
author_sort | Luo, Ziyi |
collection | PubMed |
description | Alzheimer’s disease (AD) is a multifactorial, irreversible, and incurable neurodegenerative disease. The main pathological feature of AD is the deposition of misfolded β-amyloid protein (Aβ) plaques in the brain. The abnormal accumulation of Aβ plaques leads to the loss of some neuron functions, further causing the neuron entanglement and the corresponding functional damage, which has a great impact on memory and cognitive functions. Hence, studying the accumulation mechanism of Aβ in the brain and its effect on other tissues is of great significance for the early diagnosis of AD. The current clinical studies of Aβ accumulation mainly rely on medical imaging techniques, which have some deficiencies in sensitivity and specificity. Optical imaging has recently become a research hotspot in the medical field and clinical applications, manifesting noninvasiveness, high sensitivity, absence of ionizing radiation, high contrast, and spatial resolution. Moreover, it is now emerging as a promising tool for the diagnosis and study of Aβ buildup. This review focuses on the application of the optical imaging technique for the determination of Aβ plaques in AD research. In addition, recent advances and key operational applications are discussed. |
format | Online Article Text |
id | pubmed-8392287 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83922872021-08-28 Optical Imaging of Beta-Amyloid Plaques in Alzheimer’s Disease Luo, Ziyi Xu, Hao Liu, Liwei Ohulchanskyy, Tymish Y. Qu, Junle Biosensors (Basel) Review Alzheimer’s disease (AD) is a multifactorial, irreversible, and incurable neurodegenerative disease. The main pathological feature of AD is the deposition of misfolded β-amyloid protein (Aβ) plaques in the brain. The abnormal accumulation of Aβ plaques leads to the loss of some neuron functions, further causing the neuron entanglement and the corresponding functional damage, which has a great impact on memory and cognitive functions. Hence, studying the accumulation mechanism of Aβ in the brain and its effect on other tissues is of great significance for the early diagnosis of AD. The current clinical studies of Aβ accumulation mainly rely on medical imaging techniques, which have some deficiencies in sensitivity and specificity. Optical imaging has recently become a research hotspot in the medical field and clinical applications, manifesting noninvasiveness, high sensitivity, absence of ionizing radiation, high contrast, and spatial resolution. Moreover, it is now emerging as a promising tool for the diagnosis and study of Aβ buildup. This review focuses on the application of the optical imaging technique for the determination of Aβ plaques in AD research. In addition, recent advances and key operational applications are discussed. MDPI 2021-07-29 /pmc/articles/PMC8392287/ /pubmed/34436057 http://dx.doi.org/10.3390/bios11080255 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Luo, Ziyi Xu, Hao Liu, Liwei Ohulchanskyy, Tymish Y. Qu, Junle Optical Imaging of Beta-Amyloid Plaques in Alzheimer’s Disease |
title | Optical Imaging of Beta-Amyloid Plaques in Alzheimer’s Disease |
title_full | Optical Imaging of Beta-Amyloid Plaques in Alzheimer’s Disease |
title_fullStr | Optical Imaging of Beta-Amyloid Plaques in Alzheimer’s Disease |
title_full_unstemmed | Optical Imaging of Beta-Amyloid Plaques in Alzheimer’s Disease |
title_short | Optical Imaging of Beta-Amyloid Plaques in Alzheimer’s Disease |
title_sort | optical imaging of beta-amyloid plaques in alzheimer’s disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392287/ https://www.ncbi.nlm.nih.gov/pubmed/34436057 http://dx.doi.org/10.3390/bios11080255 |
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