Cargando…
Role of SpO2/FiO2 Ratio and ROX Index in Predicting Early Invasive Mechanical Ventilation in COVID-19. A Pragmatic, Retrospective, Multi-Center Study
The ability of COVID-19 to compromise the respiratory system has generated a substantial proportion of critically ill patients in need of invasive mechanical ventilation (IMV). The objective of this paper was to analyze the prognostic ability of the pulse oximetry saturation/fraction of inspired oxy...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392288/ https://www.ncbi.nlm.nih.gov/pubmed/34440240 http://dx.doi.org/10.3390/biomedicines9081036 |
_version_ | 1783743468175097856 |
---|---|
author | Alberdi-Iglesias, Ana Martín-Rodríguez, Francisco Ortega Rabbione, Guillermo Rubio-Babiano, Ana I. Núñez-Toste, María G. Sanz-García, Ancor del Pozo Vegas, Carlos Castro Villamor, Miguel A. Martín-Conty, José L. Jorge-Soto, Cristina López-Izquierdo, Raúl |
author_facet | Alberdi-Iglesias, Ana Martín-Rodríguez, Francisco Ortega Rabbione, Guillermo Rubio-Babiano, Ana I. Núñez-Toste, María G. Sanz-García, Ancor del Pozo Vegas, Carlos Castro Villamor, Miguel A. Martín-Conty, José L. Jorge-Soto, Cristina López-Izquierdo, Raúl |
author_sort | Alberdi-Iglesias, Ana |
collection | PubMed |
description | The ability of COVID-19 to compromise the respiratory system has generated a substantial proportion of critically ill patients in need of invasive mechanical ventilation (IMV). The objective of this paper was to analyze the prognostic ability of the pulse oximetry saturation/fraction of inspired oxygen ratio (SpO2/FiO2) and the ratio of SpO2/FiO2 to the respiratory rate–ROX index–as predictors of IMV in an emergency department in confirmed COVID-19 patients. A multicenter, retrospective cohort study was carried out in four provinces of Spain between March and November 2020. The discriminative power of the predictive variable was assessed through a prediction model trained using a derivation sub-cohort and evaluated by the area under the curve (AUC) of the receiver operating characteristic (ROC) on the validation sub-cohort. A total of 2040 patients were included in the study. The IMV rate was 10.1%, with an in-hospital mortality rate of 35.3%. The performance of the SpO2/FiO2 ratio was better than the ROX index–AUC = 0.801 (95% CI 0.746–0.855) and AUC = 0.725 (95% CI 0.652–0.798), respectively. In fact, a direct comparison between AUCs resulted in significant differences (p = 0.001). SpO2 to FiO2 ratio is a simple and promising non-invasive tool for predicting risk of IMV in patients infected with COVID-19, and it is realizable in emergency departments. |
format | Online Article Text |
id | pubmed-8392288 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83922882021-08-28 Role of SpO2/FiO2 Ratio and ROX Index in Predicting Early Invasive Mechanical Ventilation in COVID-19. A Pragmatic, Retrospective, Multi-Center Study Alberdi-Iglesias, Ana Martín-Rodríguez, Francisco Ortega Rabbione, Guillermo Rubio-Babiano, Ana I. Núñez-Toste, María G. Sanz-García, Ancor del Pozo Vegas, Carlos Castro Villamor, Miguel A. Martín-Conty, José L. Jorge-Soto, Cristina López-Izquierdo, Raúl Biomedicines Article The ability of COVID-19 to compromise the respiratory system has generated a substantial proportion of critically ill patients in need of invasive mechanical ventilation (IMV). The objective of this paper was to analyze the prognostic ability of the pulse oximetry saturation/fraction of inspired oxygen ratio (SpO2/FiO2) and the ratio of SpO2/FiO2 to the respiratory rate–ROX index–as predictors of IMV in an emergency department in confirmed COVID-19 patients. A multicenter, retrospective cohort study was carried out in four provinces of Spain between March and November 2020. The discriminative power of the predictive variable was assessed through a prediction model trained using a derivation sub-cohort and evaluated by the area under the curve (AUC) of the receiver operating characteristic (ROC) on the validation sub-cohort. A total of 2040 patients were included in the study. The IMV rate was 10.1%, with an in-hospital mortality rate of 35.3%. The performance of the SpO2/FiO2 ratio was better than the ROX index–AUC = 0.801 (95% CI 0.746–0.855) and AUC = 0.725 (95% CI 0.652–0.798), respectively. In fact, a direct comparison between AUCs resulted in significant differences (p = 0.001). SpO2 to FiO2 ratio is a simple and promising non-invasive tool for predicting risk of IMV in patients infected with COVID-19, and it is realizable in emergency departments. MDPI 2021-08-18 /pmc/articles/PMC8392288/ /pubmed/34440240 http://dx.doi.org/10.3390/biomedicines9081036 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Alberdi-Iglesias, Ana Martín-Rodríguez, Francisco Ortega Rabbione, Guillermo Rubio-Babiano, Ana I. Núñez-Toste, María G. Sanz-García, Ancor del Pozo Vegas, Carlos Castro Villamor, Miguel A. Martín-Conty, José L. Jorge-Soto, Cristina López-Izquierdo, Raúl Role of SpO2/FiO2 Ratio and ROX Index in Predicting Early Invasive Mechanical Ventilation in COVID-19. A Pragmatic, Retrospective, Multi-Center Study |
title | Role of SpO2/FiO2 Ratio and ROX Index in Predicting Early Invasive Mechanical Ventilation in COVID-19. A Pragmatic, Retrospective, Multi-Center Study |
title_full | Role of SpO2/FiO2 Ratio and ROX Index in Predicting Early Invasive Mechanical Ventilation in COVID-19. A Pragmatic, Retrospective, Multi-Center Study |
title_fullStr | Role of SpO2/FiO2 Ratio and ROX Index in Predicting Early Invasive Mechanical Ventilation in COVID-19. A Pragmatic, Retrospective, Multi-Center Study |
title_full_unstemmed | Role of SpO2/FiO2 Ratio and ROX Index in Predicting Early Invasive Mechanical Ventilation in COVID-19. A Pragmatic, Retrospective, Multi-Center Study |
title_short | Role of SpO2/FiO2 Ratio and ROX Index in Predicting Early Invasive Mechanical Ventilation in COVID-19. A Pragmatic, Retrospective, Multi-Center Study |
title_sort | role of spo2/fio2 ratio and rox index in predicting early invasive mechanical ventilation in covid-19. a pragmatic, retrospective, multi-center study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392288/ https://www.ncbi.nlm.nih.gov/pubmed/34440240 http://dx.doi.org/10.3390/biomedicines9081036 |
work_keys_str_mv | AT alberdiiglesiasana roleofspo2fio2ratioandroxindexinpredictingearlyinvasivemechanicalventilationincovid19apragmaticretrospectivemulticenterstudy AT martinrodriguezfrancisco roleofspo2fio2ratioandroxindexinpredictingearlyinvasivemechanicalventilationincovid19apragmaticretrospectivemulticenterstudy AT ortegarabbioneguillermo roleofspo2fio2ratioandroxindexinpredictingearlyinvasivemechanicalventilationincovid19apragmaticretrospectivemulticenterstudy AT rubiobabianoanai roleofspo2fio2ratioandroxindexinpredictingearlyinvasivemechanicalventilationincovid19apragmaticretrospectivemulticenterstudy AT nuneztostemariag roleofspo2fio2ratioandroxindexinpredictingearlyinvasivemechanicalventilationincovid19apragmaticretrospectivemulticenterstudy AT sanzgarciaancor roleofspo2fio2ratioandroxindexinpredictingearlyinvasivemechanicalventilationincovid19apragmaticretrospectivemulticenterstudy AT delpozovegascarlos roleofspo2fio2ratioandroxindexinpredictingearlyinvasivemechanicalventilationincovid19apragmaticretrospectivemulticenterstudy AT castrovillamormiguela roleofspo2fio2ratioandroxindexinpredictingearlyinvasivemechanicalventilationincovid19apragmaticretrospectivemulticenterstudy AT martincontyjosel roleofspo2fio2ratioandroxindexinpredictingearlyinvasivemechanicalventilationincovid19apragmaticretrospectivemulticenterstudy AT jorgesotocristina roleofspo2fio2ratioandroxindexinpredictingearlyinvasivemechanicalventilationincovid19apragmaticretrospectivemulticenterstudy AT lopezizquierdoraul roleofspo2fio2ratioandroxindexinpredictingearlyinvasivemechanicalventilationincovid19apragmaticretrospectivemulticenterstudy |