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Etiology of Carpal Tunnel Syndrome in a Large Cohort of Children

(1) Background: Carpal tunnel syndrome (CTS), a compressive mononeuropathy of the median nerve at the wrist, is rare in childhood and occurs most frequently due to secondary causes. (2) Methods: Medical history, electrodiagnostic findings, and imaging data of patients with CTS from two pediatric neu...

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Autores principales: Rüsch, Christina T., Knirsch, Ursula, Weber, Daniel M., Rohrbach, Marianne, Eichenberger, André, Lütschg, Jürg, Weber, Kirsten, Broser, Philip J., Stettner, Georg M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392332/
https://www.ncbi.nlm.nih.gov/pubmed/34438514
http://dx.doi.org/10.3390/children8080624
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author Rüsch, Christina T.
Knirsch, Ursula
Weber, Daniel M.
Rohrbach, Marianne
Eichenberger, André
Lütschg, Jürg
Weber, Kirsten
Broser, Philip J.
Stettner, Georg M.
author_facet Rüsch, Christina T.
Knirsch, Ursula
Weber, Daniel M.
Rohrbach, Marianne
Eichenberger, André
Lütschg, Jürg
Weber, Kirsten
Broser, Philip J.
Stettner, Georg M.
author_sort Rüsch, Christina T.
collection PubMed
description (1) Background: Carpal tunnel syndrome (CTS), a compressive mononeuropathy of the median nerve at the wrist, is rare in childhood and occurs most frequently due to secondary causes. (2) Methods: Medical history, electrodiagnostic findings, and imaging data of patients with CTS from two pediatric neuromuscular centers were analyzed retrospectively. The etiology of CTS was investigated and compared with the literature. (3) Results: We report on a cohort of 38 CTS patients (n = 22 females, n = 29 bilateral, mean age at diagnosis 9.8 years). Electrodiagnostic studies of all patients revealed slowing of the antidromic sensory or orthodromic mixed nerve conduction velocities across the carpal tunnel or lack of the sensory nerve action potential and/or prolonged distal motor latencies. Median nerve ultrasound was diagnostic for CTS and confirmed tumorous and vascular malformations. Etiology was secondary in most patients (n = 29; 76%), and mucopolysaccharidosis was the most frequent underlying condition (n = 14; 37%). Idiopathic CTS was rare in this pediatric cohort (n = 9; 24%). (4) Conclusion: Since CTS in childhood is predominantly caused by an underlying disorder, a thorough evaluation and search for a causative condition is recommended in this age group.
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spelling pubmed-83923322021-08-28 Etiology of Carpal Tunnel Syndrome in a Large Cohort of Children Rüsch, Christina T. Knirsch, Ursula Weber, Daniel M. Rohrbach, Marianne Eichenberger, André Lütschg, Jürg Weber, Kirsten Broser, Philip J. Stettner, Georg M. Children (Basel) Article (1) Background: Carpal tunnel syndrome (CTS), a compressive mononeuropathy of the median nerve at the wrist, is rare in childhood and occurs most frequently due to secondary causes. (2) Methods: Medical history, electrodiagnostic findings, and imaging data of patients with CTS from two pediatric neuromuscular centers were analyzed retrospectively. The etiology of CTS was investigated and compared with the literature. (3) Results: We report on a cohort of 38 CTS patients (n = 22 females, n = 29 bilateral, mean age at diagnosis 9.8 years). Electrodiagnostic studies of all patients revealed slowing of the antidromic sensory or orthodromic mixed nerve conduction velocities across the carpal tunnel or lack of the sensory nerve action potential and/or prolonged distal motor latencies. Median nerve ultrasound was diagnostic for CTS and confirmed tumorous and vascular malformations. Etiology was secondary in most patients (n = 29; 76%), and mucopolysaccharidosis was the most frequent underlying condition (n = 14; 37%). Idiopathic CTS was rare in this pediatric cohort (n = 9; 24%). (4) Conclusion: Since CTS in childhood is predominantly caused by an underlying disorder, a thorough evaluation and search for a causative condition is recommended in this age group. MDPI 2021-07-23 /pmc/articles/PMC8392332/ /pubmed/34438514 http://dx.doi.org/10.3390/children8080624 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rüsch, Christina T.
Knirsch, Ursula
Weber, Daniel M.
Rohrbach, Marianne
Eichenberger, André
Lütschg, Jürg
Weber, Kirsten
Broser, Philip J.
Stettner, Georg M.
Etiology of Carpal Tunnel Syndrome in a Large Cohort of Children
title Etiology of Carpal Tunnel Syndrome in a Large Cohort of Children
title_full Etiology of Carpal Tunnel Syndrome in a Large Cohort of Children
title_fullStr Etiology of Carpal Tunnel Syndrome in a Large Cohort of Children
title_full_unstemmed Etiology of Carpal Tunnel Syndrome in a Large Cohort of Children
title_short Etiology of Carpal Tunnel Syndrome in a Large Cohort of Children
title_sort etiology of carpal tunnel syndrome in a large cohort of children
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392332/
https://www.ncbi.nlm.nih.gov/pubmed/34438514
http://dx.doi.org/10.3390/children8080624
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