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A Current Review of the Etiology, Clinical Features, and Diagnosis of Urinary Tract Infection in Renal Transplant Patients

Urinary tract infection (UTI) represents the most common infection after kidney transplantation and remains a major cause of morbidity and mortality in kidney transplant (KT) recipients, with a potential impact on graft survival. UTIs after KT are usually caused by Gram-negative microorganisms. Othe...

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Autores principales: Suárez Fernández, María Luisa, Ridao Cano, Natalia, Álvarez Santamarta, Lucia, Gago Fraile, María, Blake, Olivia, Díaz Corte, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392421/
https://www.ncbi.nlm.nih.gov/pubmed/34441390
http://dx.doi.org/10.3390/diagnostics11081456
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author Suárez Fernández, María Luisa
Ridao Cano, Natalia
Álvarez Santamarta, Lucia
Gago Fraile, María
Blake, Olivia
Díaz Corte, Carmen
author_facet Suárez Fernández, María Luisa
Ridao Cano, Natalia
Álvarez Santamarta, Lucia
Gago Fraile, María
Blake, Olivia
Díaz Corte, Carmen
author_sort Suárez Fernández, María Luisa
collection PubMed
description Urinary tract infection (UTI) represents the most common infection after kidney transplantation and remains a major cause of morbidity and mortality in kidney transplant (KT) recipients, with a potential impact on graft survival. UTIs after KT are usually caused by Gram-negative microorganisms. Other pathogens which are uncommon in the general population should be considered in KT patients, especially BK virus since an early diagnosis is necessary to improve the prognosis. UTIs following kidney transplantation are classified into acute simple cystitis, acute pyelonephritis/complicated UTI, and recurrent UTI, due to their different clinical presentation, prognosis, and management. Asymptomatic bacteriuria (ASB) represents a frequent finding after kidney transplantation, but ASB is considered to be a separate entity apart from UTI since it is not necessarily a disease state. In fact, current guidelines do not recommend routine screening and treatment of ASB in KT patients, since a beneficial effect has not been shown. Harmful effects such as the development of multidrug-resistant (MDR) bacteria and a higher incidence of Clostridium difficile diarrhea have been associated with the antibiotic treatment of ASB.
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spelling pubmed-83924212021-08-28 A Current Review of the Etiology, Clinical Features, and Diagnosis of Urinary Tract Infection in Renal Transplant Patients Suárez Fernández, María Luisa Ridao Cano, Natalia Álvarez Santamarta, Lucia Gago Fraile, María Blake, Olivia Díaz Corte, Carmen Diagnostics (Basel) Review Urinary tract infection (UTI) represents the most common infection after kidney transplantation and remains a major cause of morbidity and mortality in kidney transplant (KT) recipients, with a potential impact on graft survival. UTIs after KT are usually caused by Gram-negative microorganisms. Other pathogens which are uncommon in the general population should be considered in KT patients, especially BK virus since an early diagnosis is necessary to improve the prognosis. UTIs following kidney transplantation are classified into acute simple cystitis, acute pyelonephritis/complicated UTI, and recurrent UTI, due to their different clinical presentation, prognosis, and management. Asymptomatic bacteriuria (ASB) represents a frequent finding after kidney transplantation, but ASB is considered to be a separate entity apart from UTI since it is not necessarily a disease state. In fact, current guidelines do not recommend routine screening and treatment of ASB in KT patients, since a beneficial effect has not been shown. Harmful effects such as the development of multidrug-resistant (MDR) bacteria and a higher incidence of Clostridium difficile diarrhea have been associated with the antibiotic treatment of ASB. MDPI 2021-08-12 /pmc/articles/PMC8392421/ /pubmed/34441390 http://dx.doi.org/10.3390/diagnostics11081456 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Suárez Fernández, María Luisa
Ridao Cano, Natalia
Álvarez Santamarta, Lucia
Gago Fraile, María
Blake, Olivia
Díaz Corte, Carmen
A Current Review of the Etiology, Clinical Features, and Diagnosis of Urinary Tract Infection in Renal Transplant Patients
title A Current Review of the Etiology, Clinical Features, and Diagnosis of Urinary Tract Infection in Renal Transplant Patients
title_full A Current Review of the Etiology, Clinical Features, and Diagnosis of Urinary Tract Infection in Renal Transplant Patients
title_fullStr A Current Review of the Etiology, Clinical Features, and Diagnosis of Urinary Tract Infection in Renal Transplant Patients
title_full_unstemmed A Current Review of the Etiology, Clinical Features, and Diagnosis of Urinary Tract Infection in Renal Transplant Patients
title_short A Current Review of the Etiology, Clinical Features, and Diagnosis of Urinary Tract Infection in Renal Transplant Patients
title_sort current review of the etiology, clinical features, and diagnosis of urinary tract infection in renal transplant patients
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392421/
https://www.ncbi.nlm.nih.gov/pubmed/34441390
http://dx.doi.org/10.3390/diagnostics11081456
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