Cargando…

Evolution and Functional Characteristics of the Novel elovl8 That Play Pivotal Roles in Fatty Acid Biosynthesis

Elongation of very long-chain fatty acid (Elovl) proteins are key enzymes that catalyze the rate-limiting step in the fatty acid elongation pathway. The most recently discovered member of the Elovl family, Elovl8, has been proposed to be a fish-specific elongase with two gene paralogs described in t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sun, Shouxiang, Wang, Yumei, Goh, Pei-Tian, Lopes-Marques, Mónica, Castro, L. Filipe C., Monroig, Óscar, Kuah, Meng-Kiat, Cao, Xiaojuan, Shu-Chien, Alexander Chong, Gao, Jian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392482/ https://www.ncbi.nlm.nih.gov/pubmed/34440461 http://dx.doi.org/10.3390/genes12081287

Ejemplares similares

Evolutionary functional elaboration of the Elovl2/5 gene family in chordates
por: Monroig, Óscar, et al.
Publicado: (2016)

Quantitative Phosphoproteomic Analysis Reveals the Regulatory Networks of Elovl6 on Lipid and Glucose Metabolism in Zebrafish
por: Wang, Xueting, et al.
Publicado: (2020)

Elongation of very Long-Chain (>C(24)) Fatty Acids in Clarias gariepinus: Cloning, Functional Characterization and Tissue Expression of elovl4 Elongases
por: Oboh, Angela, et al.
Publicado: (2017)

Functional characterization and differential nutritional regulation of putative Elovl5 and Elovl4 elongases in large yellow croaker (Larimichthys crocea)
por: Li, Songlin, et al.
Publicado: (2017)

Retention of fatty acyl desaturase 1 (fads1) in Elopomorpha and Cyclostomata provides novel insights into the evolution of long-chain polyunsaturated fatty acid biosynthesis in vertebrates
por: Lopes-Marques, Mónica, et al.
Publicado: (2018)

Glioblastoma Multiforme Tumors in Women Have a Lower Expression of Fatty Acid Elongases ELOVL2, ELOVL5, ELOVL6, and ELOVL7 than in Men
por: Korbecki, Jan, et al.
Publicado: (2022)

Biosynthesis of Polyunsaturated Fatty Acids in Marine Invertebrates: Recent Advances in Molecular Mechanisms
por: Monroig, Óscar, et al.
Publicado: (2013)

Upregulated mRNA expression of desaturase and elongase, two enzymes involved in highly unsaturated fatty acids biosynthesis pathways during follicle maturation in zebrafish
por: Ishak, Sairatul D, et al.
Publicado: (2008)

ELOVL4 Mutations That Cause Spinocerebellar Ataxia-34 Differentially Alter Very Long Chain Fatty Acid Biosynthesis
por: Gyening, Yeboah Kofi, et al.
Publicado: (2022)

Genes for de novo biosynthesis of omega-3 polyunsaturated fatty acids are widespread in animals
por: Kabeya, Naoki, et al.
Publicado: (2018)

Molecular and Functional Characterization of Elovl4 Genes in Sparus aurata and Solea senegalensis Pointing to a Critical Role in Very Long-Chain (>C(24)) Fatty Acid Synthesis during Early Neural Development of Fish
por: Morais, Sofia, et al.
Publicado: (2020)

Fatty Acid Elongase 7 (ELOVL7) Plays a Role in the Synthesis of Long-Chain Unsaturated Fatty Acids in Goat Mammary Epithelial Cells
por: Shi, Hengbo, et al.
Publicado: (2019)

Remodeling of Retinal Fatty Acids in an Animal Model of Diabetes: A Decrease in Long-Chain Polyunsaturated Fatty Acids Is Associated With a Decrease in Fatty Acid Elongases Elovl2 and Elovl4
por: Tikhonenko, Maria, et al.
Publicado: (2010)

Association Analysis between Genetic Variants of elovl5a and elovl5b and Poly-Unsaturated Fatty Acids in Common Carp (Cyprinus carpio)
por: Zhang, Yan, et al.
Publicado: (2022)

Biosynthesis of Polyunsaturated Fatty Acids in Sea Urchins: Molecular and Functional Characterisation of Three Fatty Acyl Desaturases from Paracentrotus lividus (Lamark 1816)
por: Kabeya, Naoki, et al.
Publicado: (2017)

Biosynthesis of Long-Chain Polyunsaturated Fatty Acids in Marine Gammarids: Molecular Cloning and Functional Characterisation of Three Fatty Acyl Elongases
por: Ribes-Navarro, Alberto, et al.
Publicado: (2021)

rs953413 Regulates Polyunsaturated Fatty Acid Metabolism by Modulating ELOVL2 Expression
por: Pan, Gang, et al.
Publicado: (2020)

Therapeutic Role of ELOVL in Neurological Diseases
por: Siddiqui, Arif Jamal, et al.
Publicado: (2023)

Transcriptional activation of zebrafish fads2 promoter and its transient transgene expression in yolk syncytial layer of zebrafish embryos
por: Tay, Shu-Shen, et al.
Publicado: (2018)

C24:0 avoids cold exposure-induced oxidative stress and fatty acid β-oxidation damage
por: Sun, Shouxiang, et al.
Publicado: (2021)

Brown Adipose Tissue Thermogenic Capacity Is Regulated by Elovl6
por: Tan, Chong Yew, et al.
Publicado: (2015)

The role of ELOVL1 in very long-chain fatty acid homeostasis and X-linked adrenoleukodystrophy
por: Ofman, Rob, et al.
Publicado: (2010)

Endoplasmic reticulum microenvironment and conserved histidines govern ELOVL4 fatty acid elongase activity
por: Logan, Sreemathi, et al.
Publicado: (2014)

Polyunsaturated fatty acid elongation and desaturation in activated human T-cells: ELOVL5 is the key elongase
por: Robichaud, Philippe-Pierre, et al.
Publicado: (2018)

The fatty acid elongase Elovl6 is crucial for hematopoietic stem cell engraftment and leukemia propagation
por: Kiyoki, Yusuke, et al.
Publicado: (2023)

TMEM120A is a coenzyme A-binding membrane protein with structural similarities to ELOVL fatty acid elongase
por: Xue, Jing, et al.
Publicado: (2021)

Dominant Elongase Activity of Elovl5a but Higher Expression of Elovl5b in Common Carp (Cyprinus carpio)
por: Zhao, Ran, et al.
Publicado: (2022)

Two alternative pathways for docosahexaenoic acid (DHA, 22:6n-3) biosynthesis are widespread among teleost fish
por: Oboh, Angela, et al.
Publicado: (2017)

ELOVL2: Not just a biomarker of aging
por: Chao, Daniel L., et al.
Publicado: (2020)

Wax Ester Synthase/Diacylglycerol Acyltransferase Isoenzymes Play a Pivotal Role in Wax Ester Biosynthesis in Euglena gracilis
por: Tomiyama, Takuya, et al.
Publicado: (2017)

Elovl6 is a negative clinical predictor for liver cancer and knockdown of Elovl6 reduces murine liver cancer progression
por: Su, Yu-Chu, et al.
Publicado: (2018)

Biosynthesis of Polyunsaturated Fatty Acids in Octopus vulgaris: Molecular Cloning and Functional Characterisation of a Stearoyl-CoA Desaturase and an Elongation of Very Long-Chain Fatty Acid 4 Protein
por: Monroig, Óscar, et al.
Publicado: (2017)

Polymorphism in the ELOVL6 Gene Is Associated with a Major QTL Effect on Fatty Acid Composition in Pigs
por: Corominas, Jordi, et al.
Publicado: (2013)

ELOVL4: Very long-chain fatty acids serve an eclectic role in mammalian health and function
por: Hopiavuori, Blake R., et al.
Publicado: (2018)

Association of maternal weight with FADS and ELOVL genetic variants and fatty acid levels- The PREOBE follow-up
por: de la Garza Puentes, Andrea, et al.
Publicado: (2017)

Novel Cellular Functions of Very Long Chain-Fatty Acids: Insight From ELOVL4 Mutations
por: Deák, Ferenc, et al.
Publicado: (2019)

ELOVL5-Mediated Long Chain Fatty Acid Elongation Contributes to Enzalutamide Resistance of Prostate Cancer
por: Xu, Huan, et al.
Publicado: (2021)

ELOVL5‐mediated fatty acid elongation promotes cellular proliferation and invasion in renal cell carcinoma
por: Nitta, Satoshi, et al.
Publicado: (2022)

Prokineticin 2 Plays a Pivotal Role in Psoriasis
por: He, Xiaoqin, et al.
Publicado: (2016)

Elovl4a participates in LC-PUFA biosynthesis and is regulated by PPARαβ in golden pompano Trachinotus ovatus (Linnaeus 1758)
por: Zhu, Ke-Cheng, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_bc7gun67p1c46pg2ov5e7vji2v