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Beneficial Effects of Organosulfur Compounds from Allium cepa on Gut Health: A Systematic Review
Dietary changes affect the composition and structure of gut microbiota (GM) in animals and humans. One of the beneficial effects of consuming products derived from plants is the positive influence on immunity and gastrointestinal health. Species belonging to the genus Allium contain many organosulfu...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392556/ https://www.ncbi.nlm.nih.gov/pubmed/34441457 http://dx.doi.org/10.3390/foods10081680 |
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author | Guillamón, Enrique Andreo-Martínez, Pedro Mut-Salud, Nuria Fonollá, Juristo Baños, Alberto |
author_facet | Guillamón, Enrique Andreo-Martínez, Pedro Mut-Salud, Nuria Fonollá, Juristo Baños, Alberto |
author_sort | Guillamón, Enrique |
collection | PubMed |
description | Dietary changes affect the composition and structure of gut microbiota (GM) in animals and humans. One of the beneficial effects of consuming products derived from plants is the positive influence on immunity and gastrointestinal health. Species belonging to the genus Allium contain many organosulfur compounds (OSCs) that have been widely studied showing their biological properties and beneficial effects on intestinal health and GM. This is the first systematic review of OSCs from Allium performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, and it is based on the evidence that we found in literature about the benefits on the GM and intestinal health demonstrated by OSCs from Allium, and specifically from onion. OSCs from Allium cepa have shown a significant antibacterial activity against a broad spectrum of antibiotic-resistant Gram-positive and Gram-negative bacteria. In addition, the intake of OSCs from onion was able to modulate the composition of GM, increasing the beneficial bacterial populations in animal models. Moreover, the beneficial effects observed in murine models of colitis suggest that these compounds could be suitable candidates for the treatment of inflammatory bowel disease (IBD) or reverse the dysbiosis caused by a high-fat diet (HFD). Despite the evidence found both in vitro and in vivo, we have not found any article that tested OSCs different from allicin in clinical trials or dietary intervention studies in humans. In this sense, it would be interesting to conduct new research that tests the benefits of these compounds in human GM. |
format | Online Article Text |
id | pubmed-8392556 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83925562021-08-28 Beneficial Effects of Organosulfur Compounds from Allium cepa on Gut Health: A Systematic Review Guillamón, Enrique Andreo-Martínez, Pedro Mut-Salud, Nuria Fonollá, Juristo Baños, Alberto Foods Review Dietary changes affect the composition and structure of gut microbiota (GM) in animals and humans. One of the beneficial effects of consuming products derived from plants is the positive influence on immunity and gastrointestinal health. Species belonging to the genus Allium contain many organosulfur compounds (OSCs) that have been widely studied showing their biological properties and beneficial effects on intestinal health and GM. This is the first systematic review of OSCs from Allium performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, and it is based on the evidence that we found in literature about the benefits on the GM and intestinal health demonstrated by OSCs from Allium, and specifically from onion. OSCs from Allium cepa have shown a significant antibacterial activity against a broad spectrum of antibiotic-resistant Gram-positive and Gram-negative bacteria. In addition, the intake of OSCs from onion was able to modulate the composition of GM, increasing the beneficial bacterial populations in animal models. Moreover, the beneficial effects observed in murine models of colitis suggest that these compounds could be suitable candidates for the treatment of inflammatory bowel disease (IBD) or reverse the dysbiosis caused by a high-fat diet (HFD). Despite the evidence found both in vitro and in vivo, we have not found any article that tested OSCs different from allicin in clinical trials or dietary intervention studies in humans. In this sense, it would be interesting to conduct new research that tests the benefits of these compounds in human GM. MDPI 2021-07-21 /pmc/articles/PMC8392556/ /pubmed/34441457 http://dx.doi.org/10.3390/foods10081680 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Guillamón, Enrique Andreo-Martínez, Pedro Mut-Salud, Nuria Fonollá, Juristo Baños, Alberto Beneficial Effects of Organosulfur Compounds from Allium cepa on Gut Health: A Systematic Review |
title | Beneficial Effects of Organosulfur Compounds from Allium cepa on Gut Health: A Systematic Review |
title_full | Beneficial Effects of Organosulfur Compounds from Allium cepa on Gut Health: A Systematic Review |
title_fullStr | Beneficial Effects of Organosulfur Compounds from Allium cepa on Gut Health: A Systematic Review |
title_full_unstemmed | Beneficial Effects of Organosulfur Compounds from Allium cepa on Gut Health: A Systematic Review |
title_short | Beneficial Effects of Organosulfur Compounds from Allium cepa on Gut Health: A Systematic Review |
title_sort | beneficial effects of organosulfur compounds from allium cepa on gut health: a systematic review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392556/ https://www.ncbi.nlm.nih.gov/pubmed/34441457 http://dx.doi.org/10.3390/foods10081680 |
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