Cargando…

The Upper Motor Neuron—Improved Knowledge from ALS and Related Clinical Disorders

Upper motor neuron (UMN) is a term traditionally used for the corticospinal or pyramidal tract neuron synapsing with the lower motor neuron (LMN) in the anterior horns of the spinal cord. The upper motor neuron controls resting muscle tone and helps initiate voluntary movement of the musculoskeletal...

Descripción completa

Detalles Bibliográficos
Autores principales:	Menon, Parvathi, Vucic, Steve
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392624/ https://www.ncbi.nlm.nih.gov/pubmed/34439577 http://dx.doi.org/10.3390/brainsci11080958

Ejemplares similares

Utility of Transcranial Magnetic Simulation in Studying Upper Motor Neuron Dysfunction in Amyotrophic Lateral Sclerosis
por: Geevasinga, Nimeshan, et al.
Publicado: (2021)

Motor cortical function and the precision grip
por: Geevasinga, Nimeshan, et al.
Publicado: (2014)

Pathophysiology and Diagnosis of ALS: Insights from Advances in Neurophysiological Techniques
por: van den Bos, Mehdi A. J., et al.
Publicado: (2019)

Regional motor cortex dysfunction in amyotrophic lateral sclerosis
por: Menon, Parvathi, et al.
Publicado: (2019)

Utility of threshold tracking transcranial magnetic stimulation in ALS
por: Vucic, Steve, et al.
Publicado: (2018)

Cortical hyperexcitability evolves with disease progression in ALS
por: Menon, Parvathi, et al.
Publicado: (2020)

The split-elbow index: A biomarker of the split elbow sign in ALS
por: Pavey, Nathan, et al.
Publicado: (2021)

Cortical Dysfunction Underlies the Development of the Split-Hand in Amyotrophic Lateral Sclerosis
por: Menon, Parvathi, et al.
Publicado: (2014)

Spreading in ALS: The relative impact of upper and lower motor neuron involvement
por: Gromicho, Marta, et al.
Publicado: (2020)

Physiological Processes Underlying Short Interval Intracortical Facilitation in the Human Motor Cortex
por: Van den Bos, Mehdi A. J., et al.
Publicado: (2018)

Upper Motor Neuron Disorders: Primary Lateral Sclerosis, Upper Motor Neuron Dominant Amyotrophic Lateral Sclerosis, and Hereditary Spastic Paraplegia
por: Fullam, Timothy, et al.
Publicado: (2021)

New onset headache caused by histiocytic sarcoma of the spinal cord and leptomeninges: a case report
por: Silsby, Matthew, et al.
Publicado: (2021)

The Puzzling Case of Hyperexcitability in Amyotrophic Lateral Sclerosis
por: Bae, Jong Seok, et al.
Publicado: (2013)

ALS2-Related Motor Neuron Diseases: From Symptoms to Molecules
por: Miceli, Marcello, et al.
Publicado: (2022)

The strength of corticomotoneuronal drive underlies ALS split phenotypes and reflects early upper motor neuron dysfunction
por: Eisen, Andrew, et al.
Publicado: (2021)

Study protocol of RESCUE-ALS: A Phase 2, randomised, double-blind, placebo-controlled study in early symptomatic amyotrophic lateral sclerosis patients to assess bioenergetic catalysis with CNM-Au8 as a mechanism to slow disease progression
por: Vucic, Steve, et al.
Publicado: (2021)

Neurophysiological differentiation of upper motor neuron damage in neurodegenerative disorders
por: Shirota, Yuichiro, et al.
Publicado: (2022)

Upper motor neurons are a target for gene therapy and UCHL1 is necessary and sufficient to improve cellular integrity of diseased upper motor neurons
por: Genç, Barış, et al.
Publicado: (2022)

Identification and outcomes of clinical phenotypes in amyotrophic lateral sclerosis/motor neuron disease: Australian National Motor Neuron Disease observational cohort
por: Talman, Paul, et al.
Publicado: (2016)

Complexity of Generating Mouse Models to Study the Upper Motor Neurons: Let Us Shift Focus from Mice to Neurons
por: Genc, Baris, et al.
Publicado: (2019)

Lower Motor Neuron Findings after Upper Motor Neuron Injury: Insights from Postoperative Supplementary Motor Area Syndrome
por: Florman, Jeffrey E., et al.
Publicado: (2013)

ALS is a multistep process in South Korean, Japanese, and Australian patients
por: Vucic, Steve, et al.
Publicado: (2020)

Diffusion Tensor Imaging Evaluation of Corticospinal Tract Hyperintensity in Upper Motor Neuron-Predominant ALS Patients
por: Rajagopalan, Venkateswaran, et al.
Publicado: (2011)

Unbiased MRI Analyses Identify Micropathologic Differences Between Upper Motor Neuron-Predominant ALS Phenotypes
por: Rajagopalan, Venkateswaran, et al.
Publicado: (2019)

Differentiating lower motor neuron syndromes
por: Garg, Nidhi, et al.
Publicado: (2017)

Fishing for causes and cures of motor neuron disorders
por: Patten, Shunmoogum A., et al.
Publicado: (2014)

Motor Neuron Susceptibility in ALS/FTD
por: Ragagnin, Audrey M. G., et al.
Publicado: (2019)

Efficacy and safety of CNM-Au8 in amyotrophic lateral sclerosis (RESCUE-ALS study): a phase 2, randomised, double-blind, placebo-controlled trial and open label extension
por: Vucic, Steve, et al.
Publicado: (2023)

Visualization of Sensory Neurons and Their Projections in an Upper Motor Neuron Reporter Line
por: Genç, Barış, et al.
Publicado: (2015)

Lower and upper motor neuron involvement and their impact on disease prognosis in amyotrophic lateral sclerosis
por: Zakharova, Maria N., et al.
Publicado: (2021)

Motor neurons derived from ALS-related mouse iPS cells recapitulate pathological features of ALS
por: Park, Ju-Hwang, et al.
Publicado: (2016)

CSF Heavy Neurofilament May Discriminate and Predict Motor Neuron Diseases with Upper Motor Neuron Involvement
por: Simonini, Cecilia, et al.
Publicado: (2021)

Altered excitability of motor neuron pathways after stroke: more than upper motor neuron impairments
por: Li, Pingping, et al.
Publicado: (2022)

Temporal Motor Coordination in the Ankle Joint Following Upper Motor Neuron Lesions
por: Tomita, Yosuke, et al.
Publicado: (2013)

Illuminating ALS Motor Neurons With Optogenetics in Zebrafish
por: Asakawa, Kazuhide, et al.
Publicado: (2021)

Beta-band intermuscular coherence: a novel biomarker of upper motor neuron dysfunction in motor neuron disease
por: Fisher, Karen M., et al.
Publicado: (2012)

Lipidomics study of plasma from patients suggest that ALS and PLS are part of a continuum of motor neuron disorders
por: Area-Gomez, Estela, et al.
Publicado: (2021)

Astrocytes from Familial and Sporadic ALS Patients are Toxic to Motor Neurons
por: Haidet-Phillips, Amanda M., et al.
Publicado: (2011)

An Interactive Computer Game for Improving Selective Voluntary Motor Control in Children With Upper Motor Neuron Lesions: Development and Preliminary Feasibility Study
por: Fahr, Annina, et al.
Publicado: (2021)

Cortical Excitability across the ALS Clinical Motor Phenotypes
por: Dharmadasa, Thanuja
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_j7s11rt80f5gajpkvu6gdcuma6