Cargando…
Maternal Death Related to Sudden Unexpected Death in Epilepsy: A Nationwide Survey in Japan
Sudden unexpected death in epilepsy (SUDEP) is defined as the sudden death of a patient with epilepsy in the absence of an anatomic or toxicologic cause. Whether pregnancy is a risk factor for SUDEP is unclear. Using data submitted to the Japan Association of Obstetricians and Gynecologists (JAOG),...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392658/ https://www.ncbi.nlm.nih.gov/pubmed/34439614 http://dx.doi.org/10.3390/brainsci11080995 |
_version_ | 1783743555218440192 |
---|---|
author | Tanaka, Hiroaki Katsuragi, Shinji Hasegawa, Junichi Tanaka, Kayo Nakamura, Masamitsu Hayata, Eijiro Nakata, Masahiko Sekizawa, Akihiko Ishiwata, Isamu Ikeda, Tomoaki |
author_facet | Tanaka, Hiroaki Katsuragi, Shinji Hasegawa, Junichi Tanaka, Kayo Nakamura, Masamitsu Hayata, Eijiro Nakata, Masahiko Sekizawa, Akihiko Ishiwata, Isamu Ikeda, Tomoaki |
author_sort | Tanaka, Hiroaki |
collection | PubMed |
description | Sudden unexpected death in epilepsy (SUDEP) is defined as the sudden death of a patient with epilepsy in the absence of an anatomic or toxicologic cause. Whether pregnancy is a risk factor for SUDEP is unclear. Using data submitted to the Japan Association of Obstetricians and Gynecologists (JAOG), which has been collating information regarding all maternal deaths in Japan since 2000, this study evaluated maternal mortality data from 2010 to 2019 to evaluate the current circumstances of maternal death related to SUDEP in Japan. Six women died due to SUDEP during this period; the maternal mortality rate related to SUDEP was 0.066/100,000 individuals. Two women each died during the second trimester, third trimester, and postpartum period. Four and two women were receiving monotherapy and no therapy with anti-epileptic drugs, respectively. The duration of epilepsy was ≤15 years in three women, >15 years in one woman, and unknown in two women. This study furthers our understanding of the prevalence of maternal deaths due to SUDEP in Japan. Further studies are needed to confirm whether pregnancy is a risk factor for SUDEP. |
format | Online Article Text |
id | pubmed-8392658 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83926582021-08-28 Maternal Death Related to Sudden Unexpected Death in Epilepsy: A Nationwide Survey in Japan Tanaka, Hiroaki Katsuragi, Shinji Hasegawa, Junichi Tanaka, Kayo Nakamura, Masamitsu Hayata, Eijiro Nakata, Masahiko Sekizawa, Akihiko Ishiwata, Isamu Ikeda, Tomoaki Brain Sci Article Sudden unexpected death in epilepsy (SUDEP) is defined as the sudden death of a patient with epilepsy in the absence of an anatomic or toxicologic cause. Whether pregnancy is a risk factor for SUDEP is unclear. Using data submitted to the Japan Association of Obstetricians and Gynecologists (JAOG), which has been collating information regarding all maternal deaths in Japan since 2000, this study evaluated maternal mortality data from 2010 to 2019 to evaluate the current circumstances of maternal death related to SUDEP in Japan. Six women died due to SUDEP during this period; the maternal mortality rate related to SUDEP was 0.066/100,000 individuals. Two women each died during the second trimester, third trimester, and postpartum period. Four and two women were receiving monotherapy and no therapy with anti-epileptic drugs, respectively. The duration of epilepsy was ≤15 years in three women, >15 years in one woman, and unknown in two women. This study furthers our understanding of the prevalence of maternal deaths due to SUDEP in Japan. Further studies are needed to confirm whether pregnancy is a risk factor for SUDEP. MDPI 2021-07-28 /pmc/articles/PMC8392658/ /pubmed/34439614 http://dx.doi.org/10.3390/brainsci11080995 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Tanaka, Hiroaki Katsuragi, Shinji Hasegawa, Junichi Tanaka, Kayo Nakamura, Masamitsu Hayata, Eijiro Nakata, Masahiko Sekizawa, Akihiko Ishiwata, Isamu Ikeda, Tomoaki Maternal Death Related to Sudden Unexpected Death in Epilepsy: A Nationwide Survey in Japan |
title | Maternal Death Related to Sudden Unexpected Death in Epilepsy: A Nationwide Survey in Japan |
title_full | Maternal Death Related to Sudden Unexpected Death in Epilepsy: A Nationwide Survey in Japan |
title_fullStr | Maternal Death Related to Sudden Unexpected Death in Epilepsy: A Nationwide Survey in Japan |
title_full_unstemmed | Maternal Death Related to Sudden Unexpected Death in Epilepsy: A Nationwide Survey in Japan |
title_short | Maternal Death Related to Sudden Unexpected Death in Epilepsy: A Nationwide Survey in Japan |
title_sort | maternal death related to sudden unexpected death in epilepsy: a nationwide survey in japan |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392658/ https://www.ncbi.nlm.nih.gov/pubmed/34439614 http://dx.doi.org/10.3390/brainsci11080995 |
work_keys_str_mv | AT tanakahiroaki maternaldeathrelatedtosuddenunexpecteddeathinepilepsyanationwidesurveyinjapan AT katsuragishinji maternaldeathrelatedtosuddenunexpecteddeathinepilepsyanationwidesurveyinjapan AT hasegawajunichi maternaldeathrelatedtosuddenunexpecteddeathinepilepsyanationwidesurveyinjapan AT tanakakayo maternaldeathrelatedtosuddenunexpecteddeathinepilepsyanationwidesurveyinjapan AT nakamuramasamitsu maternaldeathrelatedtosuddenunexpecteddeathinepilepsyanationwidesurveyinjapan AT hayataeijiro maternaldeathrelatedtosuddenunexpecteddeathinepilepsyanationwidesurveyinjapan AT nakatamasahiko maternaldeathrelatedtosuddenunexpecteddeathinepilepsyanationwidesurveyinjapan AT sekizawaakihiko maternaldeathrelatedtosuddenunexpecteddeathinepilepsyanationwidesurveyinjapan AT ishiwataisamu maternaldeathrelatedtosuddenunexpecteddeathinepilepsyanationwidesurveyinjapan AT ikedatomoaki maternaldeathrelatedtosuddenunexpecteddeathinepilepsyanationwidesurveyinjapan |