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Maternal Death Related to Sudden Unexpected Death in Epilepsy: A Nationwide Survey in Japan

Sudden unexpected death in epilepsy (SUDEP) is defined as the sudden death of a patient with epilepsy in the absence of an anatomic or toxicologic cause. Whether pregnancy is a risk factor for SUDEP is unclear. Using data submitted to the Japan Association of Obstetricians and Gynecologists (JAOG),...

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Autores principales: Tanaka, Hiroaki, Katsuragi, Shinji, Hasegawa, Junichi, Tanaka, Kayo, Nakamura, Masamitsu, Hayata, Eijiro, Nakata, Masahiko, Sekizawa, Akihiko, Ishiwata, Isamu, Ikeda, Tomoaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392658/
https://www.ncbi.nlm.nih.gov/pubmed/34439614
http://dx.doi.org/10.3390/brainsci11080995
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author Tanaka, Hiroaki
Katsuragi, Shinji
Hasegawa, Junichi
Tanaka, Kayo
Nakamura, Masamitsu
Hayata, Eijiro
Nakata, Masahiko
Sekizawa, Akihiko
Ishiwata, Isamu
Ikeda, Tomoaki
author_facet Tanaka, Hiroaki
Katsuragi, Shinji
Hasegawa, Junichi
Tanaka, Kayo
Nakamura, Masamitsu
Hayata, Eijiro
Nakata, Masahiko
Sekizawa, Akihiko
Ishiwata, Isamu
Ikeda, Tomoaki
author_sort Tanaka, Hiroaki
collection PubMed
description Sudden unexpected death in epilepsy (SUDEP) is defined as the sudden death of a patient with epilepsy in the absence of an anatomic or toxicologic cause. Whether pregnancy is a risk factor for SUDEP is unclear. Using data submitted to the Japan Association of Obstetricians and Gynecologists (JAOG), which has been collating information regarding all maternal deaths in Japan since 2000, this study evaluated maternal mortality data from 2010 to 2019 to evaluate the current circumstances of maternal death related to SUDEP in Japan. Six women died due to SUDEP during this period; the maternal mortality rate related to SUDEP was 0.066/100,000 individuals. Two women each died during the second trimester, third trimester, and postpartum period. Four and two women were receiving monotherapy and no therapy with anti-epileptic drugs, respectively. The duration of epilepsy was ≤15 years in three women, >15 years in one woman, and unknown in two women. This study furthers our understanding of the prevalence of maternal deaths due to SUDEP in Japan. Further studies are needed to confirm whether pregnancy is a risk factor for SUDEP.
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spelling pubmed-83926582021-08-28 Maternal Death Related to Sudden Unexpected Death in Epilepsy: A Nationwide Survey in Japan Tanaka, Hiroaki Katsuragi, Shinji Hasegawa, Junichi Tanaka, Kayo Nakamura, Masamitsu Hayata, Eijiro Nakata, Masahiko Sekizawa, Akihiko Ishiwata, Isamu Ikeda, Tomoaki Brain Sci Article Sudden unexpected death in epilepsy (SUDEP) is defined as the sudden death of a patient with epilepsy in the absence of an anatomic or toxicologic cause. Whether pregnancy is a risk factor for SUDEP is unclear. Using data submitted to the Japan Association of Obstetricians and Gynecologists (JAOG), which has been collating information regarding all maternal deaths in Japan since 2000, this study evaluated maternal mortality data from 2010 to 2019 to evaluate the current circumstances of maternal death related to SUDEP in Japan. Six women died due to SUDEP during this period; the maternal mortality rate related to SUDEP was 0.066/100,000 individuals. Two women each died during the second trimester, third trimester, and postpartum period. Four and two women were receiving monotherapy and no therapy with anti-epileptic drugs, respectively. The duration of epilepsy was ≤15 years in three women, >15 years in one woman, and unknown in two women. This study furthers our understanding of the prevalence of maternal deaths due to SUDEP in Japan. Further studies are needed to confirm whether pregnancy is a risk factor for SUDEP. MDPI 2021-07-28 /pmc/articles/PMC8392658/ /pubmed/34439614 http://dx.doi.org/10.3390/brainsci11080995 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tanaka, Hiroaki
Katsuragi, Shinji
Hasegawa, Junichi
Tanaka, Kayo
Nakamura, Masamitsu
Hayata, Eijiro
Nakata, Masahiko
Sekizawa, Akihiko
Ishiwata, Isamu
Ikeda, Tomoaki
Maternal Death Related to Sudden Unexpected Death in Epilepsy: A Nationwide Survey in Japan
title Maternal Death Related to Sudden Unexpected Death in Epilepsy: A Nationwide Survey in Japan
title_full Maternal Death Related to Sudden Unexpected Death in Epilepsy: A Nationwide Survey in Japan
title_fullStr Maternal Death Related to Sudden Unexpected Death in Epilepsy: A Nationwide Survey in Japan
title_full_unstemmed Maternal Death Related to Sudden Unexpected Death in Epilepsy: A Nationwide Survey in Japan
title_short Maternal Death Related to Sudden Unexpected Death in Epilepsy: A Nationwide Survey in Japan
title_sort maternal death related to sudden unexpected death in epilepsy: a nationwide survey in japan
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392658/
https://www.ncbi.nlm.nih.gov/pubmed/34439614
http://dx.doi.org/10.3390/brainsci11080995
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