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Renal Involvement in Children with Type 2 Diabetes Mellitus Onset: A Pilot Study
Type 2 Diabetes Mellitus (T2DM) is a main cause of chronic kidney disease (CKD) in adulthood. No studies have examined the occurrence of acute kidney injury (AKI)—that enhances the risk of later CKD—and renal tubular damage (RTD)—that can evolve to AKI—in children with onset of T2DM. We aimed to eva...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392677/ https://www.ncbi.nlm.nih.gov/pubmed/34438518 http://dx.doi.org/10.3390/children8080627 |
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author | Marzuillo, Pierluigi Di Sessa, Anna Palma, Pier Luigi Umano, Giuseppina Rosaria Polito, Cesare Iafusco, Dario Guarino, Stefano Miraglia del Giudice, Emanuele |
author_facet | Marzuillo, Pierluigi Di Sessa, Anna Palma, Pier Luigi Umano, Giuseppina Rosaria Polito, Cesare Iafusco, Dario Guarino, Stefano Miraglia del Giudice, Emanuele |
author_sort | Marzuillo, Pierluigi |
collection | PubMed |
description | Type 2 Diabetes Mellitus (T2DM) is a main cause of chronic kidney disease (CKD) in adulthood. No studies have examined the occurrence of acute kidney injury (AKI)—that enhances the risk of later CKD—and renal tubular damage (RTD)—that can evolve to AKI—in children with onset of T2DM. We aimed to evaluate the prevalence and possible features of AKI and RTD in a prospectively enrolled population of children with onset of T2DM. We consecutively enrolled 10 children aged 12.9 ± 2.3 years with newly diagnosed T2DM. AKI was defined according to the KDIGO criteria. RTD was defined by abnormal urinary beta-2-microglobulin and/or tubular reabsorption of phosphate (TRP) <85% and/or fractional excretion of Na >2%. None of the patients developed AKI, whereas 3/10 developed RTD with high beta-2-microglobulin levels (range: 0.6–1.06 mg/L). One of these three patients also presented with reduced TRP levels (TRP = 70%). Proteinuria was observed in two out of three patients with RTD, while none of patients without RTD had proteinuria. Patients with RTD presented higher beta-2-microglobulin, acute creatinine/estimated basal creatinine ratio, and serum ketones levels compared with patients without RTD. In conclusion, in our pilot observation, we found that none of the 10 children with T2DM onset developed AKI, whereas three of them developed RTD. |
format | Online Article Text |
id | pubmed-8392677 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83926772021-08-28 Renal Involvement in Children with Type 2 Diabetes Mellitus Onset: A Pilot Study Marzuillo, Pierluigi Di Sessa, Anna Palma, Pier Luigi Umano, Giuseppina Rosaria Polito, Cesare Iafusco, Dario Guarino, Stefano Miraglia del Giudice, Emanuele Children (Basel) Brief Report Type 2 Diabetes Mellitus (T2DM) is a main cause of chronic kidney disease (CKD) in adulthood. No studies have examined the occurrence of acute kidney injury (AKI)—that enhances the risk of later CKD—and renal tubular damage (RTD)—that can evolve to AKI—in children with onset of T2DM. We aimed to evaluate the prevalence and possible features of AKI and RTD in a prospectively enrolled population of children with onset of T2DM. We consecutively enrolled 10 children aged 12.9 ± 2.3 years with newly diagnosed T2DM. AKI was defined according to the KDIGO criteria. RTD was defined by abnormal urinary beta-2-microglobulin and/or tubular reabsorption of phosphate (TRP) <85% and/or fractional excretion of Na >2%. None of the patients developed AKI, whereas 3/10 developed RTD with high beta-2-microglobulin levels (range: 0.6–1.06 mg/L). One of these three patients also presented with reduced TRP levels (TRP = 70%). Proteinuria was observed in two out of three patients with RTD, while none of patients without RTD had proteinuria. Patients with RTD presented higher beta-2-microglobulin, acute creatinine/estimated basal creatinine ratio, and serum ketones levels compared with patients without RTD. In conclusion, in our pilot observation, we found that none of the 10 children with T2DM onset developed AKI, whereas three of them developed RTD. MDPI 2021-07-23 /pmc/articles/PMC8392677/ /pubmed/34438518 http://dx.doi.org/10.3390/children8080627 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Brief Report Marzuillo, Pierluigi Di Sessa, Anna Palma, Pier Luigi Umano, Giuseppina Rosaria Polito, Cesare Iafusco, Dario Guarino, Stefano Miraglia del Giudice, Emanuele Renal Involvement in Children with Type 2 Diabetes Mellitus Onset: A Pilot Study |
title | Renal Involvement in Children with Type 2 Diabetes Mellitus Onset: A Pilot Study |
title_full | Renal Involvement in Children with Type 2 Diabetes Mellitus Onset: A Pilot Study |
title_fullStr | Renal Involvement in Children with Type 2 Diabetes Mellitus Onset: A Pilot Study |
title_full_unstemmed | Renal Involvement in Children with Type 2 Diabetes Mellitus Onset: A Pilot Study |
title_short | Renal Involvement in Children with Type 2 Diabetes Mellitus Onset: A Pilot Study |
title_sort | renal involvement in children with type 2 diabetes mellitus onset: a pilot study |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392677/ https://www.ncbi.nlm.nih.gov/pubmed/34438518 http://dx.doi.org/10.3390/children8080627 |
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