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Renal Involvement in Children with Type 2 Diabetes Mellitus Onset: A Pilot Study

Type 2 Diabetes Mellitus (T2DM) is a main cause of chronic kidney disease (CKD) in adulthood. No studies have examined the occurrence of acute kidney injury (AKI)—that enhances the risk of later CKD—and renal tubular damage (RTD)—that can evolve to AKI—in children with onset of T2DM. We aimed to eva...

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Autores principales: Marzuillo, Pierluigi, Di Sessa, Anna, Palma, Pier Luigi, Umano, Giuseppina Rosaria, Polito, Cesare, Iafusco, Dario, Guarino, Stefano, Miraglia del Giudice, Emanuele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392677/
https://www.ncbi.nlm.nih.gov/pubmed/34438518
http://dx.doi.org/10.3390/children8080627
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author Marzuillo, Pierluigi
Di Sessa, Anna
Palma, Pier Luigi
Umano, Giuseppina Rosaria
Polito, Cesare
Iafusco, Dario
Guarino, Stefano
Miraglia del Giudice, Emanuele
author_facet Marzuillo, Pierluigi
Di Sessa, Anna
Palma, Pier Luigi
Umano, Giuseppina Rosaria
Polito, Cesare
Iafusco, Dario
Guarino, Stefano
Miraglia del Giudice, Emanuele
author_sort Marzuillo, Pierluigi
collection PubMed
description Type 2 Diabetes Mellitus (T2DM) is a main cause of chronic kidney disease (CKD) in adulthood. No studies have examined the occurrence of acute kidney injury (AKI)—that enhances the risk of later CKD—and renal tubular damage (RTD)—that can evolve to AKI—in children with onset of T2DM. We aimed to evaluate the prevalence and possible features of AKI and RTD in a prospectively enrolled population of children with onset of T2DM. We consecutively enrolled 10 children aged 12.9 ± 2.3 years with newly diagnosed T2DM. AKI was defined according to the KDIGO criteria. RTD was defined by abnormal urinary beta-2-microglobulin and/or tubular reabsorption of phosphate (TRP) <85% and/or fractional excretion of Na >2%. None of the patients developed AKI, whereas 3/10 developed RTD with high beta-2-microglobulin levels (range: 0.6–1.06 mg/L). One of these three patients also presented with reduced TRP levels (TRP = 70%). Proteinuria was observed in two out of three patients with RTD, while none of patients without RTD had proteinuria. Patients with RTD presented higher beta-2-microglobulin, acute creatinine/estimated basal creatinine ratio, and serum ketones levels compared with patients without RTD. In conclusion, in our pilot observation, we found that none of the 10 children with T2DM onset developed AKI, whereas three of them developed RTD.
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spelling pubmed-83926772021-08-28 Renal Involvement in Children with Type 2 Diabetes Mellitus Onset: A Pilot Study Marzuillo, Pierluigi Di Sessa, Anna Palma, Pier Luigi Umano, Giuseppina Rosaria Polito, Cesare Iafusco, Dario Guarino, Stefano Miraglia del Giudice, Emanuele Children (Basel) Brief Report Type 2 Diabetes Mellitus (T2DM) is a main cause of chronic kidney disease (CKD) in adulthood. No studies have examined the occurrence of acute kidney injury (AKI)—that enhances the risk of later CKD—and renal tubular damage (RTD)—that can evolve to AKI—in children with onset of T2DM. We aimed to evaluate the prevalence and possible features of AKI and RTD in a prospectively enrolled population of children with onset of T2DM. We consecutively enrolled 10 children aged 12.9 ± 2.3 years with newly diagnosed T2DM. AKI was defined according to the KDIGO criteria. RTD was defined by abnormal urinary beta-2-microglobulin and/or tubular reabsorption of phosphate (TRP) <85% and/or fractional excretion of Na >2%. None of the patients developed AKI, whereas 3/10 developed RTD with high beta-2-microglobulin levels (range: 0.6–1.06 mg/L). One of these three patients also presented with reduced TRP levels (TRP = 70%). Proteinuria was observed in two out of three patients with RTD, while none of patients without RTD had proteinuria. Patients with RTD presented higher beta-2-microglobulin, acute creatinine/estimated basal creatinine ratio, and serum ketones levels compared with patients without RTD. In conclusion, in our pilot observation, we found that none of the 10 children with T2DM onset developed AKI, whereas three of them developed RTD. MDPI 2021-07-23 /pmc/articles/PMC8392677/ /pubmed/34438518 http://dx.doi.org/10.3390/children8080627 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Marzuillo, Pierluigi
Di Sessa, Anna
Palma, Pier Luigi
Umano, Giuseppina Rosaria
Polito, Cesare
Iafusco, Dario
Guarino, Stefano
Miraglia del Giudice, Emanuele
Renal Involvement in Children with Type 2 Diabetes Mellitus Onset: A Pilot Study
title Renal Involvement in Children with Type 2 Diabetes Mellitus Onset: A Pilot Study
title_full Renal Involvement in Children with Type 2 Diabetes Mellitus Onset: A Pilot Study
title_fullStr Renal Involvement in Children with Type 2 Diabetes Mellitus Onset: A Pilot Study
title_full_unstemmed Renal Involvement in Children with Type 2 Diabetes Mellitus Onset: A Pilot Study
title_short Renal Involvement in Children with Type 2 Diabetes Mellitus Onset: A Pilot Study
title_sort renal involvement in children with type 2 diabetes mellitus onset: a pilot study
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392677/
https://www.ncbi.nlm.nih.gov/pubmed/34438518
http://dx.doi.org/10.3390/children8080627
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