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Influence of the Levels of Arsenic, Cadmium, Mercury and Lead on Overall Survival in Lung Cancer

The effects of heavy metals on cancer risk have been widely studied in recent decades, but there is limited data on the effects of these elements on cancer survival. In this research, we examined whether blood concentrations of the heavy metals arsenic, cadmium, mercury and lead were associated with...

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Autores principales: Pietrzak, Sandra, Wójcik, Janusz, Baszuk, Piotr, Marciniak, Wojciech, Wojtyś, Małgorzata, Dębniak, Tadeusz, Cybulski, Cezary, Gronwald, Jacek, Alchimowicz, Jacek, Masojć, Bartłomiej, Waloszczyk, Piotr, Gajić, Darko, Grodzki, Tomasz, Jakubowska, Anna, Scott, Rodney J., Lubiński, Jan, Lener, Marcin R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392714/
https://www.ncbi.nlm.nih.gov/pubmed/34439826
http://dx.doi.org/10.3390/biom11081160
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author Pietrzak, Sandra
Wójcik, Janusz
Baszuk, Piotr
Marciniak, Wojciech
Wojtyś, Małgorzata
Dębniak, Tadeusz
Cybulski, Cezary
Gronwald, Jacek
Alchimowicz, Jacek
Masojć, Bartłomiej
Waloszczyk, Piotr
Gajić, Darko
Grodzki, Tomasz
Jakubowska, Anna
Scott, Rodney J.
Lubiński, Jan
Lener, Marcin R.
author_facet Pietrzak, Sandra
Wójcik, Janusz
Baszuk, Piotr
Marciniak, Wojciech
Wojtyś, Małgorzata
Dębniak, Tadeusz
Cybulski, Cezary
Gronwald, Jacek
Alchimowicz, Jacek
Masojć, Bartłomiej
Waloszczyk, Piotr
Gajić, Darko
Grodzki, Tomasz
Jakubowska, Anna
Scott, Rodney J.
Lubiński, Jan
Lener, Marcin R.
author_sort Pietrzak, Sandra
collection PubMed
description The effects of heavy metals on cancer risk have been widely studied in recent decades, but there is limited data on the effects of these elements on cancer survival. In this research, we examined whether blood concentrations of the heavy metals arsenic, cadmium, mercury and lead were associated with the overall survival of lung cancer patients. The study group consisted of 336 patients with lung cancer who were prospectively observed. Blood concentrations of heavy metals were measured to study the relationship between their levels and overall survival using Cox proportional hazards analysis. The hazard ratio of death from all causes was 0.99 (p = 0.94) for arsenic, 1.37 (p = 0.15) for cadmium, 1.55 (p = 0.04) for mercury, and 1.18 (p = 0.47) for lead in patients from the lowest concentration quartile, compared with those in the highest quartile. Among the patients with stage IA disease, this relationship was statistically significant (HR = 7.36; p < 0.01) for cadmium levels in the highest quartile (>1.97–7.77 µg/L) compared to quartile I (0.23–0.57 µg/L, reference). This study revealed that low blood cadmium levels <1.47 µg/L are probably associated with improved overall survival in treated patients with stage IA disease.
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spelling pubmed-83927142021-08-28 Influence of the Levels of Arsenic, Cadmium, Mercury and Lead on Overall Survival in Lung Cancer Pietrzak, Sandra Wójcik, Janusz Baszuk, Piotr Marciniak, Wojciech Wojtyś, Małgorzata Dębniak, Tadeusz Cybulski, Cezary Gronwald, Jacek Alchimowicz, Jacek Masojć, Bartłomiej Waloszczyk, Piotr Gajić, Darko Grodzki, Tomasz Jakubowska, Anna Scott, Rodney J. Lubiński, Jan Lener, Marcin R. Biomolecules Article The effects of heavy metals on cancer risk have been widely studied in recent decades, but there is limited data on the effects of these elements on cancer survival. In this research, we examined whether blood concentrations of the heavy metals arsenic, cadmium, mercury and lead were associated with the overall survival of lung cancer patients. The study group consisted of 336 patients with lung cancer who were prospectively observed. Blood concentrations of heavy metals were measured to study the relationship between their levels and overall survival using Cox proportional hazards analysis. The hazard ratio of death from all causes was 0.99 (p = 0.94) for arsenic, 1.37 (p = 0.15) for cadmium, 1.55 (p = 0.04) for mercury, and 1.18 (p = 0.47) for lead in patients from the lowest concentration quartile, compared with those in the highest quartile. Among the patients with stage IA disease, this relationship was statistically significant (HR = 7.36; p < 0.01) for cadmium levels in the highest quartile (>1.97–7.77 µg/L) compared to quartile I (0.23–0.57 µg/L, reference). This study revealed that low blood cadmium levels <1.47 µg/L are probably associated with improved overall survival in treated patients with stage IA disease. MDPI 2021-08-05 /pmc/articles/PMC8392714/ /pubmed/34439826 http://dx.doi.org/10.3390/biom11081160 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pietrzak, Sandra
Wójcik, Janusz
Baszuk, Piotr
Marciniak, Wojciech
Wojtyś, Małgorzata
Dębniak, Tadeusz
Cybulski, Cezary
Gronwald, Jacek
Alchimowicz, Jacek
Masojć, Bartłomiej
Waloszczyk, Piotr
Gajić, Darko
Grodzki, Tomasz
Jakubowska, Anna
Scott, Rodney J.
Lubiński, Jan
Lener, Marcin R.
Influence of the Levels of Arsenic, Cadmium, Mercury and Lead on Overall Survival in Lung Cancer
title Influence of the Levels of Arsenic, Cadmium, Mercury and Lead on Overall Survival in Lung Cancer
title_full Influence of the Levels of Arsenic, Cadmium, Mercury and Lead on Overall Survival in Lung Cancer
title_fullStr Influence of the Levels of Arsenic, Cadmium, Mercury and Lead on Overall Survival in Lung Cancer
title_full_unstemmed Influence of the Levels of Arsenic, Cadmium, Mercury and Lead on Overall Survival in Lung Cancer
title_short Influence of the Levels of Arsenic, Cadmium, Mercury and Lead on Overall Survival in Lung Cancer
title_sort influence of the levels of arsenic, cadmium, mercury and lead on overall survival in lung cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392714/
https://www.ncbi.nlm.nih.gov/pubmed/34439826
http://dx.doi.org/10.3390/biom11081160
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