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Neuroprotective Potential of Mild Uncoupling in Mitochondria. Pros and Cons
There has been an explosion of interest in the use of uncouplers of oxidative phosphorylation in mitochondria in the treatment of several pathologies, including neurological ones. In this review, we analyzed all the mechanisms associated with mitochondrial uncoupling and the metabolic and signaling...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392724/ https://www.ncbi.nlm.nih.gov/pubmed/34439669 http://dx.doi.org/10.3390/brainsci11081050 |
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| author | Zorov, Dmitry B. Andrianova, Nadezda V. Babenko, Valentina A. Pevzner, Irina B. Popkov, Vasily A. Zorov, Savva D. Zorova, Ljubava D. Plotnikov, Egor Yu. Sukhikh, Gennady T. Silachev, Denis N. |
| author_facet | Zorov, Dmitry B. Andrianova, Nadezda V. Babenko, Valentina A. Pevzner, Irina B. Popkov, Vasily A. Zorov, Savva D. Zorova, Ljubava D. Plotnikov, Egor Yu. Sukhikh, Gennady T. Silachev, Denis N. |
| author_sort | Zorov, Dmitry B. |
| collection | PubMed |
| description | There has been an explosion of interest in the use of uncouplers of oxidative phosphorylation in mitochondria in the treatment of several pathologies, including neurological ones. In this review, we analyzed all the mechanisms associated with mitochondrial uncoupling and the metabolic and signaling cascades triggered by uncouplers. We provide a full set of positive and negative effects that should be taken into account when using uncouplers in experiments and clinical practice. |
| format | Online Article Text |
| id | pubmed-8392724 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-83927242021-08-28 Neuroprotective Potential of Mild Uncoupling in Mitochondria. Pros and Cons Zorov, Dmitry B. Andrianova, Nadezda V. Babenko, Valentina A. Pevzner, Irina B. Popkov, Vasily A. Zorov, Savva D. Zorova, Ljubava D. Plotnikov, Egor Yu. Sukhikh, Gennady T. Silachev, Denis N. Brain Sci Review There has been an explosion of interest in the use of uncouplers of oxidative phosphorylation in mitochondria in the treatment of several pathologies, including neurological ones. In this review, we analyzed all the mechanisms associated with mitochondrial uncoupling and the metabolic and signaling cascades triggered by uncouplers. We provide a full set of positive and negative effects that should be taken into account when using uncouplers in experiments and clinical practice. MDPI 2021-08-08 /pmc/articles/PMC8392724/ /pubmed/34439669 http://dx.doi.org/10.3390/brainsci11081050 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Review Zorov, Dmitry B. Andrianova, Nadezda V. Babenko, Valentina A. Pevzner, Irina B. Popkov, Vasily A. Zorov, Savva D. Zorova, Ljubava D. Plotnikov, Egor Yu. Sukhikh, Gennady T. Silachev, Denis N. Neuroprotective Potential of Mild Uncoupling in Mitochondria. Pros and Cons |
| title | Neuroprotective Potential of Mild Uncoupling in Mitochondria. Pros and Cons |
| title_full | Neuroprotective Potential of Mild Uncoupling in Mitochondria. Pros and Cons |
| title_fullStr | Neuroprotective Potential of Mild Uncoupling in Mitochondria. Pros and Cons |
| title_full_unstemmed | Neuroprotective Potential of Mild Uncoupling in Mitochondria. Pros and Cons |
| title_short | Neuroprotective Potential of Mild Uncoupling in Mitochondria. Pros and Cons |
| title_sort | neuroprotective potential of mild uncoupling in mitochondria. pros and cons |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392724/ https://www.ncbi.nlm.nih.gov/pubmed/34439669 http://dx.doi.org/10.3390/brainsci11081050 |
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