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Achieving brain clearance and preventing neurodegenerative diseases—A glymphatic perspective

Age-related neurodegenerative diseases are a growing burden to society, and many are sporadic, meaning that the environment, diet and lifestyle play significant roles. Cerebrospinal fluid (CSF)-mediated clearing of brain waste products via perivascular pathways, named the glymphatic system, is recei...

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Autores principales: Kylkilahti, Tekla Maria, Berends, Eline, Ramos, Marta, Shanbhag, Nagesh C, Töger, Johannes, Markenroth Bloch, Karin, Lundgaard, Iben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392766/
https://www.ncbi.nlm.nih.gov/pubmed/33461408
http://dx.doi.org/10.1177/0271678X20982388
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author Kylkilahti, Tekla Maria
Berends, Eline
Ramos, Marta
Shanbhag, Nagesh C
Töger, Johannes
Markenroth Bloch, Karin
Lundgaard, Iben
author_facet Kylkilahti, Tekla Maria
Berends, Eline
Ramos, Marta
Shanbhag, Nagesh C
Töger, Johannes
Markenroth Bloch, Karin
Lundgaard, Iben
author_sort Kylkilahti, Tekla Maria
collection PubMed
description Age-related neurodegenerative diseases are a growing burden to society, and many are sporadic, meaning that the environment, diet and lifestyle play significant roles. Cerebrospinal fluid (CSF)-mediated clearing of brain waste products via perivascular pathways, named the glymphatic system, is receiving increasing interest, as it offers unexplored perspectives on understanding neurodegenerative diseases. The glymphatic system is involved in clearance of metabolic by-products such as amyloid-β from the brain, and its function is believed to lower the risk of developing some of the most common neurodegenerative diseases. Here, we present magnetic resonance imaging (MRI) data on the heart cycle’s control of CSF flow in humans which corroborates findings from animal studies. We also review the importance of sleep, diet, vascular health for glymphatic clearance and find that these factors are also known players in brain longevity.
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spelling pubmed-83927662021-08-28 Achieving brain clearance and preventing neurodegenerative diseases—A glymphatic perspective Kylkilahti, Tekla Maria Berends, Eline Ramos, Marta Shanbhag, Nagesh C Töger, Johannes Markenroth Bloch, Karin Lundgaard, Iben J Cereb Blood Flow Metab Review Articles Age-related neurodegenerative diseases are a growing burden to society, and many are sporadic, meaning that the environment, diet and lifestyle play significant roles. Cerebrospinal fluid (CSF)-mediated clearing of brain waste products via perivascular pathways, named the glymphatic system, is receiving increasing interest, as it offers unexplored perspectives on understanding neurodegenerative diseases. The glymphatic system is involved in clearance of metabolic by-products such as amyloid-β from the brain, and its function is believed to lower the risk of developing some of the most common neurodegenerative diseases. Here, we present magnetic resonance imaging (MRI) data on the heart cycle’s control of CSF flow in humans which corroborates findings from animal studies. We also review the importance of sleep, diet, vascular health for glymphatic clearance and find that these factors are also known players in brain longevity. SAGE Publications 2021-01-18 2021-09 /pmc/articles/PMC8392766/ /pubmed/33461408 http://dx.doi.org/10.1177/0271678X20982388 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review Articles
Kylkilahti, Tekla Maria
Berends, Eline
Ramos, Marta
Shanbhag, Nagesh C
Töger, Johannes
Markenroth Bloch, Karin
Lundgaard, Iben
Achieving brain clearance and preventing neurodegenerative diseases—A glymphatic perspective
title Achieving brain clearance and preventing neurodegenerative diseases—A glymphatic perspective
title_full Achieving brain clearance and preventing neurodegenerative diseases—A glymphatic perspective
title_fullStr Achieving brain clearance and preventing neurodegenerative diseases—A glymphatic perspective
title_full_unstemmed Achieving brain clearance and preventing neurodegenerative diseases—A glymphatic perspective
title_short Achieving brain clearance and preventing neurodegenerative diseases—A glymphatic perspective
title_sort achieving brain clearance and preventing neurodegenerative diseases—a glymphatic perspective
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392766/
https://www.ncbi.nlm.nih.gov/pubmed/33461408
http://dx.doi.org/10.1177/0271678X20982388
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