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Neutrophil Interactions with the Lymphatic System

The lymphatic system is a complex network of lymphatic vessels and lymph nodes designed to balance fluid homeostasis and facilitate host immune defence. Neutrophils are rapidly recruited to sites of inflammation to provide the first line of protection against microbial infections. The traditional vi...

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Detalles Bibliográficos
Autores principales: Jakovija, Arnolda, Chtanova, Tatyana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393351/
https://www.ncbi.nlm.nih.gov/pubmed/34440875
http://dx.doi.org/10.3390/cells10082106
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author Jakovija, Arnolda
Chtanova, Tatyana
author_facet Jakovija, Arnolda
Chtanova, Tatyana
author_sort Jakovija, Arnolda
collection PubMed
description The lymphatic system is a complex network of lymphatic vessels and lymph nodes designed to balance fluid homeostasis and facilitate host immune defence. Neutrophils are rapidly recruited to sites of inflammation to provide the first line of protection against microbial infections. The traditional view of neutrophils as short-lived cells, whose role is restricted to providing sterilizing immunity at sites of infection, is rapidly evolving to include additional functions at the interface between the innate and adaptive immune systems. Neutrophils travel via the lymphatics from the site of inflammation to transport antigens to lymph nodes. They can also enter lymph nodes from the blood by crossing high endothelial venules. Neutrophil functions in draining lymph nodes include pathogen control and modulation of adaptive immunity. Another facet of neutrophil interactions with the lymphatic system is their ability to promote lymphangiogenesis in draining lymph nodes and inflamed tissues. In this review, we discuss the significance of neutrophil migration to secondary lymphoid organs and within the lymphatic vasculature and highlight emerging evidence of the neutrophils’ role in lymphangiogenesis.
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spelling pubmed-83933512021-08-28 Neutrophil Interactions with the Lymphatic System Jakovija, Arnolda Chtanova, Tatyana Cells Review The lymphatic system is a complex network of lymphatic vessels and lymph nodes designed to balance fluid homeostasis and facilitate host immune defence. Neutrophils are rapidly recruited to sites of inflammation to provide the first line of protection against microbial infections. The traditional view of neutrophils as short-lived cells, whose role is restricted to providing sterilizing immunity at sites of infection, is rapidly evolving to include additional functions at the interface between the innate and adaptive immune systems. Neutrophils travel via the lymphatics from the site of inflammation to transport antigens to lymph nodes. They can also enter lymph nodes from the blood by crossing high endothelial venules. Neutrophil functions in draining lymph nodes include pathogen control and modulation of adaptive immunity. Another facet of neutrophil interactions with the lymphatic system is their ability to promote lymphangiogenesis in draining lymph nodes and inflamed tissues. In this review, we discuss the significance of neutrophil migration to secondary lymphoid organs and within the lymphatic vasculature and highlight emerging evidence of the neutrophils’ role in lymphangiogenesis. MDPI 2021-08-17 /pmc/articles/PMC8393351/ /pubmed/34440875 http://dx.doi.org/10.3390/cells10082106 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jakovija, Arnolda
Chtanova, Tatyana
Neutrophil Interactions with the Lymphatic System
title Neutrophil Interactions with the Lymphatic System
title_full Neutrophil Interactions with the Lymphatic System
title_fullStr Neutrophil Interactions with the Lymphatic System
title_full_unstemmed Neutrophil Interactions with the Lymphatic System
title_short Neutrophil Interactions with the Lymphatic System
title_sort neutrophil interactions with the lymphatic system
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393351/
https://www.ncbi.nlm.nih.gov/pubmed/34440875
http://dx.doi.org/10.3390/cells10082106
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