Cargando…

In Vivo Lentiviral Gene Delivery of HLA-DR and Vaccination of Humanized Mice for Improving the Human T and B Cell Immune Reconstitution

Humanized mouse models generated with human hematopoietic stem cells (HSCs) and reconstituting the human immune system (HIS-mice) are invigorating preclinical testing of vaccines and immunotherapies. We have recently shown that human engineered dendritic cells boosted bonafide human T and B cell mat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kumar, Suresh, Koenig, Johannes, Schneider, Andreas, Wermeling, Fredrik, Boddul, Sanjaykumar, Theobald, Sebastian J., Vollmer, Miriam, Kloos, Doreen, Lachmann, Nico, Klawonn, Frank, Lienenklaus, Stefan, Talbot, Steven R., Bleich, André, Wenzel, Nadine, von Kaisenberg, Constantin, Keck, James, Stripecke, Renata
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393476/ https://www.ncbi.nlm.nih.gov/pubmed/34440166 http://dx.doi.org/10.3390/biomedicines9080961

Ejemplares similares

A rapid CRISPR competitive assay for in vitro and in vivo discovery of potential drug targets affecting the hematopoietic system
por: Shen, Yunbing, et al.
Publicado: (2021)

CAR-T Cells Targeting Epstein-Barr Virus gp350 Validated in a Humanized Mouse Model of EBV Infection and Lymphoproliferative Disease
por: Slabik, Constanze, et al.
Publicado: (2020)

PD-1 Blockade Aggravates Epstein–Barr Virus(+) Post-Transplant Lymphoproliferative Disorder in Humanized Mice Resulting in Central Nervous System Involvement and CD4(+) T Cell Dysregulations
por: Volk, Valery, et al.
Publicado: (2021)

Designing custom CRISPR libraries for hypothesis-driven drug target discovery
por: Iyer, Vaishnavi Srinivasan, et al.
Publicado: (2020)

Modeling Human Cytomegalovirus in Humanized Mice for Vaccine Testing
por: Koenig, Johannes, et al.
Publicado: (2020)

CRISPR/Cas9-Induced DNA Damage Enriches for Mutations in a p53-Linked Interactome: Implications for CRISPR-Based Therapies
por: Jiang, Long, et al.
Publicado: (2022)

In vitro and ex vivo functional characterization of human HLA-DRB1∗04 restricted T cell receptors
por: Boddul, Sanjaykumar V., et al.
Publicado: (2021)

Reconstructing the immune system with lentiviral vectors
por: Olbrich, Henning, et al.
Publicado: (2017)

Spatiotemporally Skewed Activation of Programmed Cell Death Receptor 1–Positive T Cells after Epstein-Barr Virus Infection and Tumor Development in Long-Term Fully Humanized Mice
por: Danisch, Simon, et al.
Publicado: (2019)

IL-4 controls activated neutrophil FcγR2b expression and migration into inflamed joints
por: Panda, Sudeepta Kumar, et al.
Publicado: (2020)

Pulmonary transplantation of alpha-1 antitrypsin (AAT)-transgenic macrophages provides a source of functional human AAT in vivo
por: Janosz, Ewa, et al.
Publicado: (2021)

Reconstitution of the Ataxia-Telangiectasia Cellular Phenotype With Lentiviral Vectors
por: Carranza, Diana, et al.
Publicado: (2018)

The gender gap: discrepant human T-cell reconstitution after cord blood stem cell transplantation in humanized female and male mice
por: Volk, V, et al.
Publicado: (2016)

Repertoire characterization and validation of gB-specific human IgGs directly cloned from humanized mice vaccinated with dendritic cells and protected against HCMV
por: Theobald, Sebastian J., et al.
Publicado: (2020)

Correction: Repertoire characterization and validation of gB-specific human IgGs directly cloned from humanized mice vaccinated with dendritic cells and protected against HCMV
por: Theobald, Sebastian J., et al.
Publicado: (2021)

Biosynthesis of prostaglandin 15dPGJ(2) -glutathione and 15dPGJ(2)-cysteine conjugates in macrophages and mast cells via MGST3
por: Steinmetz-Späh, Julia, et al.
Publicado: (2022)

Biased TCR gene usage in citrullinated Tenascin C specific T-cells in rheumatoid arthritis
por: Sharma, Ravi K., et al.
Publicado: (2021)

B-cell reconstitution after lentiviral vector–mediated gene therapy in patients with Wiskott-Aldrich syndrome
por: Castiello, Maria Carmina, et al.
Publicado: (2015)

Human Lentiviral Gene Therapy Restores the Cellular Phenotype of Autosomal Recessive Complete IFN-γR1 Deficiency
por: Hahn, Katharina, et al.
Publicado: (2020)

Ex Vivo Generation of CAR Macrophages from Hematopoietic Stem and Progenitor Cells for Use in Cancer Therapy
por: Paasch, Daniela, et al.
Publicado: (2022)

Lentiviral vectors for induction of self-differentiation and conditional ablation of dendritic cells
por: Pincha, M, et al.
Publicado: (2011)

Signatures of T and B Cell Development, Functional Responses and PD-1 Upregulation After HCMV Latent Infections and Reactivations in Nod.Rag.Gamma Mice Humanized With Cord Blood CD34(+) Cells
por: Theobald, Sebastian J., et al.
Publicado: (2018)

Multidimensional Analysis Integrating Human T-Cell Signatures in Lymphatic Tissues with Sex of Humanized Mice for Prediction of Responses after Dendritic Cell Immunization
por: Volk, Valery, et al.
Publicado: (2017)

Genetic Correction of IL-10RB Deficiency Reconstitutes Anti-Inflammatory Regulation in iPSC-Derived Macrophages
por: Hoffmann, Dirk, et al.
Publicado: (2021)

Monocytes reprogrammed with lentiviral vectors co-expressing GM-CSF, IFN-α2 and antigens for personalized immune therapy of acute leukemia pre- or post-stem cell transplantation
por: Bialek-Waldmann, Julia K., et al.
Publicado: (2019)

Gene Therapy Applications of Non-Human Lentiviral Vectors
por: Munis, Altar M.
Publicado: (2020)

An intronic deletion in megakaryoblastic leukemia 1 is associated with hyperproliferation of B cells in triplets with Hodgkin lymphoma
por: Record, Julien, et al.
Publicado: (2020)

Engineered dendritic cells from cord blood and adult blood accelerate effector T cell immune reconstitution against HCMV
por: Daenthanasanmak, Anusara, et al.
Publicado: (2015)

Reconstitution of an Infectious Human Endogenous Retrovirus
por: Lee, Young Nam, et al.
Publicado: (2007)

Reconstitution of Human Keloids in Mouse Skin
por: Sunaga, Ataru, et al.
Publicado: (2017)

Establishment of a Lentiviral Vector Encoding Human HGF and the Infection of Human ADSCs
por: Zhu, Xiaoyu, et al.
Publicado: (2013)

A CRISPR-p53 interactome with potential implications for clinical CRISPR/Cas9 use
por: Jiang, Long, et al.
Publicado: (2022)

Hypoxia-inducible lentiviral gene expression in engineered human macrophages
por: Chinn, Harrison K, et al.
Publicado: (2022)

Reconstitution of human RNA interference in budding yeast
por: Suk, Kyoungho, et al.
Publicado: (2011)

Reconstituting Drosophila Centromere Identity in Human Cells
por: Roure, Virginie, et al.
Publicado: (2019)

Reconstitution of Human Necrosome Interactions in Saccharomyces cerevisiae
por: Ji, Y., et al.
Publicado: (2021)

Reconstitution of an active human CENP-E motor
por: Craske, Benjamin, et al.
Publicado: (2022)

Human Olfactory Receptor Sensor for Odor Reconstitution
por: Kuroda, Shun’ichi, et al.
Publicado: (2023)

A public genome-scale lentiviral expression library of human ORFs
por: Yang, Xiaoping, et al.
Publicado: (2011)

A High-Throughput Platform for Lentiviral Overexpression Screening of the Human ORFeome
por: Škalamera, Dubravka, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_ihgpp75ko9amhfkbldkeov37ta