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GIST and Ghrelin: To Be or Not to Be?

Background: Ghrelin is the orexigenic hormone secreted mainly by the stomach. Its involvement in neoplastic development has been studied in gastrointestinal adenocarcinomas. Our paper aims to evaluate the influence of the ghrelin axis in gastrointestinal stromal tumors (GISTs). Materials and Methods...

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Autores principales: Spiridon, Irene Alexandra, Ciobanu, Delia Gabriela Apostol, Giușcă, Simona Eliza, Ferariu, Dan, Pleşca, Iulia Cătălina, Căruntu, Irina Draga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393501/
https://www.ncbi.nlm.nih.gov/pubmed/34441296
http://dx.doi.org/10.3390/diagnostics11081361
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author Spiridon, Irene Alexandra
Ciobanu, Delia Gabriela Apostol
Giușcă, Simona Eliza
Ferariu, Dan
Pleşca, Iulia Cătălina
Căruntu, Irina Draga
author_facet Spiridon, Irene Alexandra
Ciobanu, Delia Gabriela Apostol
Giușcă, Simona Eliza
Ferariu, Dan
Pleşca, Iulia Cătălina
Căruntu, Irina Draga
author_sort Spiridon, Irene Alexandra
collection PubMed
description Background: Ghrelin is the orexigenic hormone secreted mainly by the stomach. Its involvement in neoplastic development has been studied in gastrointestinal adenocarcinomas. Our paper aims to evaluate the influence of the ghrelin axis in gastrointestinal stromal tumors (GISTs). Materials and Methods: The study design included two groups of patients, 46 with gastric GISTs and 30 with obesity. Archived tissue samples were evaluated for the presence of gastritis and H. pylori. Immunohistochemical expression of ghrelin and its receptor (GHS-R) was assessed. Results: All GISTs showed absent immunohistochemical expression for ghrelin, while GHS-R displayed a particular pattern, with notable differences in intensity (p = 0.0256) and percentage of stained cells (p < 0.00001) in the periphery vs. core of tumors. Positive ghrelin expression was lower in the gastric mucosa of the first group compared to the second group (p < 0.001). Conclusion: The ghrelin axis can influence GISTs carcinogenesis through activation of GHS-R. A previously described direct autocrine/paracrine mechanism is not supported by our findings.
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spelling pubmed-83935012021-08-28 GIST and Ghrelin: To Be or Not to Be? Spiridon, Irene Alexandra Ciobanu, Delia Gabriela Apostol Giușcă, Simona Eliza Ferariu, Dan Pleşca, Iulia Cătălina Căruntu, Irina Draga Diagnostics (Basel) Article Background: Ghrelin is the orexigenic hormone secreted mainly by the stomach. Its involvement in neoplastic development has been studied in gastrointestinal adenocarcinomas. Our paper aims to evaluate the influence of the ghrelin axis in gastrointestinal stromal tumors (GISTs). Materials and Methods: The study design included two groups of patients, 46 with gastric GISTs and 30 with obesity. Archived tissue samples were evaluated for the presence of gastritis and H. pylori. Immunohistochemical expression of ghrelin and its receptor (GHS-R) was assessed. Results: All GISTs showed absent immunohistochemical expression for ghrelin, while GHS-R displayed a particular pattern, with notable differences in intensity (p = 0.0256) and percentage of stained cells (p < 0.00001) in the periphery vs. core of tumors. Positive ghrelin expression was lower in the gastric mucosa of the first group compared to the second group (p < 0.001). Conclusion: The ghrelin axis can influence GISTs carcinogenesis through activation of GHS-R. A previously described direct autocrine/paracrine mechanism is not supported by our findings. MDPI 2021-07-29 /pmc/articles/PMC8393501/ /pubmed/34441296 http://dx.doi.org/10.3390/diagnostics11081361 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Spiridon, Irene Alexandra
Ciobanu, Delia Gabriela Apostol
Giușcă, Simona Eliza
Ferariu, Dan
Pleşca, Iulia Cătălina
Căruntu, Irina Draga
GIST and Ghrelin: To Be or Not to Be?
title GIST and Ghrelin: To Be or Not to Be?
title_full GIST and Ghrelin: To Be or Not to Be?
title_fullStr GIST and Ghrelin: To Be or Not to Be?
title_full_unstemmed GIST and Ghrelin: To Be or Not to Be?
title_short GIST and Ghrelin: To Be or Not to Be?
title_sort gist and ghrelin: to be or not to be?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393501/
https://www.ncbi.nlm.nih.gov/pubmed/34441296
http://dx.doi.org/10.3390/diagnostics11081361
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