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GIST and Ghrelin: To Be or Not to Be?
Background: Ghrelin is the orexigenic hormone secreted mainly by the stomach. Its involvement in neoplastic development has been studied in gastrointestinal adenocarcinomas. Our paper aims to evaluate the influence of the ghrelin axis in gastrointestinal stromal tumors (GISTs). Materials and Methods...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393501/ https://www.ncbi.nlm.nih.gov/pubmed/34441296 http://dx.doi.org/10.3390/diagnostics11081361 |
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author | Spiridon, Irene Alexandra Ciobanu, Delia Gabriela Apostol Giușcă, Simona Eliza Ferariu, Dan Pleşca, Iulia Cătălina Căruntu, Irina Draga |
author_facet | Spiridon, Irene Alexandra Ciobanu, Delia Gabriela Apostol Giușcă, Simona Eliza Ferariu, Dan Pleşca, Iulia Cătălina Căruntu, Irina Draga |
author_sort | Spiridon, Irene Alexandra |
collection | PubMed |
description | Background: Ghrelin is the orexigenic hormone secreted mainly by the stomach. Its involvement in neoplastic development has been studied in gastrointestinal adenocarcinomas. Our paper aims to evaluate the influence of the ghrelin axis in gastrointestinal stromal tumors (GISTs). Materials and Methods: The study design included two groups of patients, 46 with gastric GISTs and 30 with obesity. Archived tissue samples were evaluated for the presence of gastritis and H. pylori. Immunohistochemical expression of ghrelin and its receptor (GHS-R) was assessed. Results: All GISTs showed absent immunohistochemical expression for ghrelin, while GHS-R displayed a particular pattern, with notable differences in intensity (p = 0.0256) and percentage of stained cells (p < 0.00001) in the periphery vs. core of tumors. Positive ghrelin expression was lower in the gastric mucosa of the first group compared to the second group (p < 0.001). Conclusion: The ghrelin axis can influence GISTs carcinogenesis through activation of GHS-R. A previously described direct autocrine/paracrine mechanism is not supported by our findings. |
format | Online Article Text |
id | pubmed-8393501 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83935012021-08-28 GIST and Ghrelin: To Be or Not to Be? Spiridon, Irene Alexandra Ciobanu, Delia Gabriela Apostol Giușcă, Simona Eliza Ferariu, Dan Pleşca, Iulia Cătălina Căruntu, Irina Draga Diagnostics (Basel) Article Background: Ghrelin is the orexigenic hormone secreted mainly by the stomach. Its involvement in neoplastic development has been studied in gastrointestinal adenocarcinomas. Our paper aims to evaluate the influence of the ghrelin axis in gastrointestinal stromal tumors (GISTs). Materials and Methods: The study design included two groups of patients, 46 with gastric GISTs and 30 with obesity. Archived tissue samples were evaluated for the presence of gastritis and H. pylori. Immunohistochemical expression of ghrelin and its receptor (GHS-R) was assessed. Results: All GISTs showed absent immunohistochemical expression for ghrelin, while GHS-R displayed a particular pattern, with notable differences in intensity (p = 0.0256) and percentage of stained cells (p < 0.00001) in the periphery vs. core of tumors. Positive ghrelin expression was lower in the gastric mucosa of the first group compared to the second group (p < 0.001). Conclusion: The ghrelin axis can influence GISTs carcinogenesis through activation of GHS-R. A previously described direct autocrine/paracrine mechanism is not supported by our findings. MDPI 2021-07-29 /pmc/articles/PMC8393501/ /pubmed/34441296 http://dx.doi.org/10.3390/diagnostics11081361 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Spiridon, Irene Alexandra Ciobanu, Delia Gabriela Apostol Giușcă, Simona Eliza Ferariu, Dan Pleşca, Iulia Cătălina Căruntu, Irina Draga GIST and Ghrelin: To Be or Not to Be? |
title | GIST and Ghrelin: To Be or Not to Be? |
title_full | GIST and Ghrelin: To Be or Not to Be? |
title_fullStr | GIST and Ghrelin: To Be or Not to Be? |
title_full_unstemmed | GIST and Ghrelin: To Be or Not to Be? |
title_short | GIST and Ghrelin: To Be or Not to Be? |
title_sort | gist and ghrelin: to be or not to be? |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393501/ https://www.ncbi.nlm.nih.gov/pubmed/34441296 http://dx.doi.org/10.3390/diagnostics11081361 |
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