SARS-CoV-2 S2P spike ages through distinct states with altered immunogenicity

The SARS-CoV-2 spike is the primary target of virus-neutralizing antibodies and critical to the development of effective vaccines against COVID-19. Here, we demonstrate that the prefusion-stabilized two-proline “S2P” spike—widely employed for laboratory work and clinical studies—unfolds when stored...

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Detalles Bibliográficos
Autores principales: Olia, Adam S., Tsybovsky, Yaroslav, Chen, Steven J., Liu, Cuiping, Nazzari, Alexandra F., Ou, Li, Wang, Lingshu, Kong, Wing-Pui, Leung, Kwan, Liu, Tracy, Stephens, Tyler, Teng, I-Ting, Wang, Shuishu, Yang, Eun Sung, Zhang, Baoshan, Zhang, Yi, Zhou, Tongqing, Mascola, John R., Kwong, Peter D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393506/
https://www.ncbi.nlm.nih.gov/pubmed/34461095
http://dx.doi.org/10.1016/j.jbc.2021.101127

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