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Analysis of Selected Variants of DRD2 and ANKK1 Genes in Combat Athletes
The level of physical activity is conditioned by many different factors, including, among others, the personality traits of a person. Important is the fact that personality traits are a moderately heritable factor and on the basis of the analysis of several genes, various lifetime outcomes can be pr...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393533/ https://www.ncbi.nlm.nih.gov/pubmed/34440413 http://dx.doi.org/10.3390/genes12081239 |
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author | Michałowska-Sawczyn, Monika Chmielowiec, Krzysztof Chmielowiec, Jolanta Trybek, Grzegorz Masiak, Jolanta Niewczas, Marta Cieszczyk, Paweł Bajorek, Wojciech Król, Paweł Grzywacz, Anna |
author_facet | Michałowska-Sawczyn, Monika Chmielowiec, Krzysztof Chmielowiec, Jolanta Trybek, Grzegorz Masiak, Jolanta Niewczas, Marta Cieszczyk, Paweł Bajorek, Wojciech Król, Paweł Grzywacz, Anna |
author_sort | Michałowska-Sawczyn, Monika |
collection | PubMed |
description | The level of physical activity is conditioned by many different factors, including, among others, the personality traits of a person. Important is the fact that personality traits are a moderately heritable factor and on the basis of the analysis of several genes, various lifetime outcomes can be predicted. One of the most important pathways influencing personality traits is connected to the dopaminergic system; hence, we decided to analyze the DRD2 PROM. rs1799732, DRD2 rs1076560, DRD2 Tag1D rs1800498, DRD2 Ex8 rs6276, DRD2Tag1B rs1079597 and ANKK1 Tag1A rs180049. The research group included 258 male athletes (mean age = 26.02; SD = 8.30), whereas the control group was 284 healthy male volunteers matched for age (mean age = 22.89; SD = 4.78), both of Caucasian origin and without history of substance dependency or psychosis. Genomic DNA was extracted from venous blood using standard procedures. Genotyping was conducted with the real-time PCR method. Differences in the frequency of the DRD2Tag1B rs1079597 gene polymorphism were found between people practicing combat sports and the control group, and the DRD2 PROM. rs1799732, DRD2 rs1076560, DRD2 Tag1D rs1800498, DRD2 Ex8 rs6276, DRD2Tag1B rs1079597 and ANKK1 Tag1A rs1800497 genotypes and allele frequencies in the studied sample did not differ between the analyzed groups. Hence, we considered these polymorphic places as an interesting area for the further search for unambiguous associations between personality traits and attitude towards physical effort. |
format | Online Article Text |
id | pubmed-8393533 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83935332021-08-28 Analysis of Selected Variants of DRD2 and ANKK1 Genes in Combat Athletes Michałowska-Sawczyn, Monika Chmielowiec, Krzysztof Chmielowiec, Jolanta Trybek, Grzegorz Masiak, Jolanta Niewczas, Marta Cieszczyk, Paweł Bajorek, Wojciech Król, Paweł Grzywacz, Anna Genes (Basel) Article The level of physical activity is conditioned by many different factors, including, among others, the personality traits of a person. Important is the fact that personality traits are a moderately heritable factor and on the basis of the analysis of several genes, various lifetime outcomes can be predicted. One of the most important pathways influencing personality traits is connected to the dopaminergic system; hence, we decided to analyze the DRD2 PROM. rs1799732, DRD2 rs1076560, DRD2 Tag1D rs1800498, DRD2 Ex8 rs6276, DRD2Tag1B rs1079597 and ANKK1 Tag1A rs180049. The research group included 258 male athletes (mean age = 26.02; SD = 8.30), whereas the control group was 284 healthy male volunteers matched for age (mean age = 22.89; SD = 4.78), both of Caucasian origin and without history of substance dependency or psychosis. Genomic DNA was extracted from venous blood using standard procedures. Genotyping was conducted with the real-time PCR method. Differences in the frequency of the DRD2Tag1B rs1079597 gene polymorphism were found between people practicing combat sports and the control group, and the DRD2 PROM. rs1799732, DRD2 rs1076560, DRD2 Tag1D rs1800498, DRD2 Ex8 rs6276, DRD2Tag1B rs1079597 and ANKK1 Tag1A rs1800497 genotypes and allele frequencies in the studied sample did not differ between the analyzed groups. Hence, we considered these polymorphic places as an interesting area for the further search for unambiguous associations between personality traits and attitude towards physical effort. MDPI 2021-08-13 /pmc/articles/PMC8393533/ /pubmed/34440413 http://dx.doi.org/10.3390/genes12081239 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Michałowska-Sawczyn, Monika Chmielowiec, Krzysztof Chmielowiec, Jolanta Trybek, Grzegorz Masiak, Jolanta Niewczas, Marta Cieszczyk, Paweł Bajorek, Wojciech Król, Paweł Grzywacz, Anna Analysis of Selected Variants of DRD2 and ANKK1 Genes in Combat Athletes |
title | Analysis of Selected Variants of DRD2 and ANKK1 Genes in Combat Athletes |
title_full | Analysis of Selected Variants of DRD2 and ANKK1 Genes in Combat Athletes |
title_fullStr | Analysis of Selected Variants of DRD2 and ANKK1 Genes in Combat Athletes |
title_full_unstemmed | Analysis of Selected Variants of DRD2 and ANKK1 Genes in Combat Athletes |
title_short | Analysis of Selected Variants of DRD2 and ANKK1 Genes in Combat Athletes |
title_sort | analysis of selected variants of drd2 and ankk1 genes in combat athletes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393533/ https://www.ncbi.nlm.nih.gov/pubmed/34440413 http://dx.doi.org/10.3390/genes12081239 |
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